公开(公告)号：EP2470179B1

公开(公告)日：2017-11-29

申请号：EP10763453.7

申请日：2010-08-25

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Hadasit Medical Research Services and Development Ltd. ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： FRIEDMAN, Michael ,  CZERNINSKI, Rakefet ,  GUTKIND, Silvio ,  STEINBERG, Doron ,  GATI, Irith ,  NUDELMAN, Zakhar

IPC分类号： A61K31/436 ,  A61K9/00 ,  A61K9/20 ,  A61K9/70 ,  A61P35/00

CPC分类号： A61K31/436 ,  A61K9/006 ,  A61K9/2054 ,  A61K9/7015

摘要： The present invention discloses a method of treating a head and neck cancer or preventing the development of pre-malignant lesions to this cancer, by administering locally to the oral cavity, a sustained release drug delivery system comprising a drug for the treatment of this cancer or for the prevention of said lesions, and at least one polymer, such that said system is attached to a surface in the oral cavity and remains attached thereto for at least 1 hour, accompanied by release of the drug and maintaining an effective therapeutic concentration thereof in the cavity, for at least 1 hour. Further are disclosed a sustained release drug delivery system and a liquid precursor varnish composition to this system.

公开(公告)号：EP3846781A1

公开(公告)日：2021-07-14

申请号：EP19779197.3

申请日：2019-09-05

申请人： Yissum Research Development Company of The Hebrew University of Jerusalem Ltd.

发明人： FRIEDMAN, Michael ,  KIRMAYER, David ,  NUDELMAN, Zakhar ,  HOFFMAN, Amnon ,  LAVY, Eran ,  BAR-HAI, Ayala ,  GATI, Irith

IPC分类号： A61K9/08 ,  A61K31/165 ,  A61K31/43 ,  A61K31/7048 ,  A61K47/18 ,  A61K47/38 ,  A61P31/04

公开(公告)号：EP2485713B1

公开(公告)日：2018-09-26

申请号：EP10784350.0

申请日：2010-10-05

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem

发明人： FRIEDMAN, Michael ,  STEINBERG, Doron ,  GATI, Irith

IPC分类号： A61K9/08 ,  A61K9/70 ,  A61K9/12 ,  A61C8/00 ,  A61K6/08 ,  A61Q11/00

CPC分类号： A61Q11/00 ,  A61K8/347 ,  A61K8/43 ,  A61K8/4926 ,  A61K8/731 ,  A61K8/86 ,  A61K9/0063 ,  A61K9/08 ,  A61K9/7007 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K2800/31 ,  A61K2800/594

摘要： The present invention discloses liquid precursor compositions adapted for application on a hard surface in the oral cavity, comprising at least one therapeutic agent suitable for the treatment of oral disorders, at least one acidic-pH sensitive polymer, at least one hydrophobic polymer, and a pharmaceutically acceptable volatile carrier, wherein a weight ratio between said at least one hydrophobic polymer and said at least one acidic-pH sensitive polymer is larger than 1. The invention also discloses formulations formed of the solidification of these compositions, and methods for treating oral disorders by applying these compositions on hard surfaces in the oral cavity or to be placed in the oral cavity.

公开(公告)号：EP2485713A1

公开(公告)日：2012-08-15

申请号：EP10784350.0

申请日：2010-10-05

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem

发明人： FRIEDMAN, Michael ,  STEINBERG, Doron ,  GATI, Irith

IPC分类号： A61K9/08 ,  A61K9/70 ,  A61K9/12 ,  A61C8/00 ,  A61K6/08 ,  A61Q11/00

CPC分类号： A61Q11/00 ,  A61K8/347 ,  A61K8/43 ,  A61K8/4926 ,  A61K8/731 ,  A61K8/86 ,  A61K9/0063 ,  A61K9/08 ,  A61K9/7007 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38 ,  A61K2800/31 ,  A61K2800/594

摘要： The present invention discloses liquid precursor compositions adapted for application on a hard surface in the oral cavity, comprising at least one therapeutic agent suitable for the treatment of oral disorders, at least one acidic-pH sensitive polymer, at least one hydrophobic polymer, and a pharmaceutically acceptable volatile carrier, wherein a weight ratio between said at least one hydrophobic polymer and said at least one acidic-pH sensitive polymer is larger than 1. The invention also discloses formulations formed of the solidification of these compositions, and methods for treating oral disorders by applying these compositions on hard surfaces in the oral cavity or to be placed in the oral cavity.

公开(公告)号：EP2470179A2

公开(公告)日：2012-07-04

申请号：EP10763453.7

申请日：2010-08-25

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. ,  Hadasit Medical Research Services and Development Ltd. ,  The U.S.A. as represented by the Secretary, Department of Health and Human Services

发明人： FRIEDMAN, Michael ,  CZERNINSKI, Rakefet ,  GUTKIND, Silvio ,  STEINBERG, Doron ,  GATI, Irith ,  NUDELMAN, Zakhar

IPC分类号： A61K31/436 ,  A61K8/22 ,  A61K9/00 ,  A61K9/20 ,  A61K9/70 ,  A61P35/00

CPC分类号： A61K31/436 ,  A61K9/006 ,  A61K9/2054 ,  A61K9/7015

摘要： The present invention discloses a method of treating a head and neck cancer or preventing the development of pre-malignant lesions to this cancer, by administering locally to the oral cavity, a sustained release drug delivery system comprising a drug for the treatment of this cancer or for the prevention of said lesions, and at least one polymer, such that said system is attached to a surface in the oral cavity and remains attached thereto for at least 1 hour, accompanied by release of the drug and maintaining an effective therapeutic concentration thereof in the cavity, for at least 1 hour. Further are disclosed a sustained release drug delivery system and a liquid precursor varnish composition to this system.

摘要翻译： 本发明盘松治疗头部和颈部癌症或预防癌前病变的发展这种癌症，通过局部给予至口腔，持续释放的药物递送系统，其包括药物这种癌症的治疗或方法 用于预防说病变，和至少一种聚合物，检查了所述系统被附着到表面在口腔中并保持与其连接为至少1小时，通过将药物的释放伴随以及它们在有效治疗浓度的维护 所述腔，对于至少1小时。 进一步是游离缺失盘的持续释放药物递送系统和液体前体清漆组合物，此系统。