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公开(公告)号：EP0973579A1
公开(公告)日：2000-01-26
申请号：EP98918621.8
申请日：1998-04-23
发明人： BERNARD, Robert, M.
IPC分类号： A61N1/30
CPC分类号： A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/306 , A61N1/325 , A61N1/326 , A61N1/327
摘要： Electrodes and electrode array apparatus and systems for in vivo delivery of electrical waveforms rendering therapeutic benefit to the patient are disclosed.
摘要翻译： 公开了用于向患者体内递送赋予治疗益处的电波形的电极和电极阵列设备和系统。
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2.发明公开
公开(公告)号：EP2929909A1
公开(公告)日：2015-10-14
申请号：EP15165174.2
申请日：2005-03-08
CPC分类号： A61N1/0502 , A61N1/08 , A61N1/30 , A61N1/325 , A61N1/327
摘要： Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes a least in their deployed state.
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3.发明公开
公开(公告)号：EP1729848A4
公开(公告)日：2011-04-13
申请号：EP05725237
申请日：2005-03-08
CPC分类号： A61N1/0502 , A61N1/08 , A61N1/30 , A61N1/325 , A61N1/327
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4.发明公开IMPROVED APPARATUS FOR ELECTRICALLY MEDIATED DELIVERY OF THERAPEUTIC AGENTS 有权VERBESSERTESGERÄTFÜRDIE ELEKTRISCH VERMITTELTE ABGABE VON THERAPEUTIKA
公开(公告)号：EP1729848A1
公开(公告)日：2006-12-13
申请号：EP05725237.1
申请日：2005-03-08
IPC分类号： A61N1/30
CPC分类号： A61N1/0502 , A61N1/08 , A61N1/30 , A61N1/325 , A61N1/327
摘要： Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes at least in their deployed state.
摘要翻译： 用于递送电场的装置，其有助于将治疗剂细胞内递送到患者组织内的预定部位。 该装置将包括以预定空间关系布置的多个穿透电极，每个电极具有有助于所有电极的总横截面面积的横截面面积，以及结合装置，其结合有可操作地连接到多个电极的无生命力源 用于展开电极，其中能量源足以在电极展开开始时施加至少1000磅/平方英寸（0.7千克/平方毫米）所有电极的总横截面面积的力。 该装置还将包括用于产生促进治疗剂的细胞内递送的电场的装置，该装置至少在其展开状态下可操作地连接到所述电极。
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公开(公告)号：EP3466483A9
公开(公告)日：2020-03-11
申请号：EP18188950.2
申请日：2005-03-08
摘要： Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes a least in their deployed state.
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公开(公告)号：EP2929909B1
公开(公告)日：2018-08-15
申请号：EP15165174.2
申请日：2005-03-08
CPC分类号： A61N1/0502 , A61N1/08 , A61N1/30 , A61N1/325 , A61N1/327
摘要： Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes a least in their deployed state.
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公开(公告)号：EP1128828A1
公开(公告)日：2001-09-05
申请号：EP99951877.2
申请日：1999-10-14
IPC分类号： A61K31/355 , A61K31/56 , A61K31/57 , A61K31/573 , A61K38/08 , A61N1/30
摘要： Methods for improving the efficiency of electroporation protocols as well as methods to enhance the permeabilized state, in order to improve the intracellular delivery of therapeutic substances, involve the use of at least one agent which is capable of prolonging the permeability of the cell membranes in the tissue exposed to an electroporation-inducing field.
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公开(公告)号：EP3466483A8
公开(公告)日：2020-03-04
申请号：EP18188950.2
申请日：2005-03-08
摘要： Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes a least in their deployed state.
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9.发明授权
公开(公告)号：EP1729848B1
公开(公告)日：2015-04-29
申请号：EP05725237.1
申请日：2005-03-08
CPC分类号： A61N1/0502 , A61N1/08 , A61N1/30 , A61N1/325 , A61N1/327
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公开(公告)号：EP1496986A1
公开(公告)日：2005-01-19
申请号：EP03726188.0
申请日：2003-04-04
IPC分类号： A61N1/18
CPC分类号： A61M5/2033 , A61M5/20 , A61M5/2053 , A61M5/30 , A61M5/326 , A61M5/46 , A61M2005/206 , A61N1/30 , A61N1/306
摘要： Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a patient. The invention comprises means for the controlled administration of the therapeutic agent through an orifice to the patient, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and means for generating an electrical signal operatively connected to the electrodes.
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