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公开(公告)号：EP0973579A1
公开(公告)日：2000-01-26
申请号：EP98918621.8
申请日：1998-04-23
发明人： BERNARD, Robert, M.
IPC分类号： A61N1/30
CPC分类号： A61N1/0424 , A61N1/044 , A61N1/0476 , A61N1/306 , A61N1/325 , A61N1/326 , A61N1/327
摘要： Electrodes and electrode array apparatus and systems for in vivo delivery of electrical waveforms rendering therapeutic benefit to the patient are disclosed.
摘要翻译： 公开了用于向患者体内递送赋予治疗益处的电波形的电极和电极阵列设备和系统。
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公开(公告)号：EP3466483A9
公开(公告)日：2020-03-11
申请号：EP18188950.2
申请日：2005-03-08
摘要： Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes a least in their deployed state.
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公开(公告)号：EP2929909B1
公开(公告)日：2018-08-15
申请号：EP15165174.2
申请日：2005-03-08
CPC分类号： A61N1/0502 , A61N1/08 , A61N1/30 , A61N1/325 , A61N1/327
摘要： Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes a least in their deployed state.
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公开(公告)号：EP1128828A1
公开(公告)日：2001-09-05
申请号：EP99951877.2
申请日：1999-10-14
IPC分类号： A61K31/355 , A61K31/56 , A61K31/57 , A61K31/573 , A61K38/08 , A61N1/30
摘要： Methods for improving the efficiency of electroporation protocols as well as methods to enhance the permeabilized state, in order to improve the intracellular delivery of therapeutic substances, involve the use of at least one agent which is capable of prolonging the permeability of the cell membranes in the tissue exposed to an electroporation-inducing field.
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公开(公告)号：EP3727441A1
公开(公告)日：2020-10-28
申请号：EP18830986.8
申请日：2018-12-18
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公开(公告)号：EP3466483A1
公开(公告)日：2019-04-10
申请号：EP18188950.2
申请日：2005-03-08
摘要： Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes a least in their deployed state.
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公开(公告)号：EP3436139A1
公开(公告)日：2019-02-06
申请号：EP17776508.8
申请日：2017-03-28
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公开(公告)号：EP1100580A1
公开(公告)日：2001-05-23
申请号：EP99935311.3
申请日：1999-07-20
IPC分类号： A61N1/30
CPC分类号： A61N1/0424
摘要： Electrodes, electrode array apparatus (A), and systems improve the therapeutic effects of in vivo delivered electrical waveform by utilizing an arrangement wherein the electrode plates satisfy particular ratios of electrode surface areas to separation distances between the electrode plates (X1, X2).
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公开(公告)号：EP3466483A8
公开(公告)日：2020-03-04
申请号：EP18188950.2
申请日：2005-03-08
摘要： Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes a least in their deployed state.
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10.发明授权
公开(公告)号：EP1729848B1
公开(公告)日：2015-04-29
申请号：EP05725237.1
申请日：2005-03-08
CPC分类号： A61N1/0502 , A61N1/08 , A61N1/30 , A61N1/325 , A61N1/327
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