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1.发明公开
公开(公告)号：EP4433161A1
公开(公告)日：2024-09-25
申请号：EP22818686.2
申请日：2022-11-17
申请人： Samsara Therapeutics Inc. , Institut National de la Santé et de la Recherche Médicale (INSERM) , Université de Paris Cité , Sorbonne Université
发明人： HAMLEY, Peter , GALLOWAY, Warren , KEPP, Oliver , KROEMER, Guido
IPC分类号： A61P9/00 , A61P25/08 , A61P25/28 , A61P29/00 , A61P31/00 , A61P35/00 , A61P43/00 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14 , A61K31/426 , A61K31/454 , A61K31/4155
CPC分类号： C07D417/14 , C07D401/14 , C07D417/04 , C07D409/14 , C07D409/04 , C07D405/14 , C07D403/04 , C07D403/14 , A61P25/28 , A61P35/00 , A61P25/08 , A61P31/00 , A61P9/00 , A61P29/00 , A61P43/00
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公开(公告)号：EP4424671A1
公开(公告)日：2024-09-04
申请号：EP22887535.7
申请日：2022-10-24
申请人： Huchembio Co., Ltd.
发明人： LEE, Sang Hak , YOON, Mi Ja , KIM, Mi Sun , LEE, Do Hyung , KANG, Seung Hee
IPC分类号： C07D217/02 , A61K31/472 , A61K31/4725 , A61K31/4985 , A61K31/517 , A61K31/4375 , A61K31/437 , A23L33/10 , C07D405/04 , C07D409/04
CPC分类号： A23L33/10 , A61K31/437 , A61K31/4375 , A61K31/472 , A61K31/4725 , A61K31/4985 , A61K31/517 , C07D217/02 , C07D409/04 , C07D405/04
摘要： The present invention relates to a novel tricyclic derivative compound or a pharmaceutically acceptable salt thereof and a use thereof, in which it has excellent STAT3 inhibitory activity and was found to exhibit an excellent inhibitory effect compared to known compounds in phase-3 clinical trials, and thus can be used as a therapeutic agent for STAT3 related diseases.
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3.发明授权
公开(公告)号：EP3598515B1
公开(公告)日：2024-09-04
申请号：EP18184297.2
申请日：2018-07-18
IPC分类号： C07D221/18 , C07D239/26 , C07D251/24 , C07D403/10 , C07D239/70 , C07D405/04 , C07F9/53 , C07F9/6521 , C07D409/04 , C07D401/10 , H10K85/60
CPC分类号： C07D221/18 , C07D239/26 , C07D239/70 , C07D251/24 , C07D401/10 , C07D403/10 , C07D405/04 , C07D409/04 , C07F9/5325 , C07F9/6521 , Y02E10/549 , H10K85/615 , H10K85/654
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4.发明授权
公开(公告)号：EP3917908B1
公开(公告)日：2024-08-14
申请号：EP20747897.5
申请日：2020-01-27
IPC分类号： C07D231/12 , C07D409/04 , B01J19/00
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公开(公告)号：EP3708634B1
公开(公告)日：2024-08-14
申请号：EP20165606.3
申请日：2014-11-21
IPC分类号： C09K11/06
CPC分类号： C07D307/94 , C07F9/65517 , C07D405/04 , C07D405/10 , C07D409/04 , C09K11/06 , C09K2211/100720130101 , C09K2211/101120130101 , C09K2211/102920130101 , C09K2211/104420130101 , C09K2211/105920130101 , C09K2211/108820130101 , C09K2211/109220130101 , C07F15/0033 , C07F15/0086 , C07F5/025 , Y02E10/549 , C09K11/025 , H10K85/624 , H10K50/165 , H10K50/11
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公开(公告)号：EP4225736B1
公开(公告)日：2024-07-24
申请号：EP21786502.1
申请日：2021-10-08
IPC分类号： C07D213/70 , C07D213/79 , C07D213/81 , C07D213/84 , C07D409/04
CPC分类号： C07D213/79 , C07D213/81 , C07D213/84 , C07D213/70 , C07D409/04
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公开(公告)号：EP3994113B1
公开(公告)日：2024-07-03
申请号：EP20742680.0
申请日：2020-07-14
IPC分类号： C07F15/04 , C07B37/04 , C07B43/04 , C07D217/24 , C07D409/04 , C07D213/12 , C07D209/12 , C07D295/073 , C07D311/60 , B01J31/18 , B01J31/22 , B01J31/24
CPC分类号： C07F15/04 , C07B43/04 , C07D217/24 , C07D409/04 , C07B37/04 , C07D213/12 , C07D295/073 , C07D311/60 , C07D209/12 , B01J31/2291 , B01J2231/42520130101 , B01J31/2404 , B01J2540/22520130101 , B01J2231/32320130101 , B01J2231/6420130101 , B01J2540/2220130101 , B01J2231/5220130101 , B01J31/182 , B01J2231/426120130101 , B01J2231/421620130101 , B01J2531/84720130101 , B01J2231/2020130101 , B01J31/2457 , B01J2231/424420130101 , B01J2231/4920130101 , B01J31/1815 , B01J31/2409 , B01J2231/428320130101 , B01J2531/020520130101 , B01J2531/84220130101 , B01J31/2273 , B01J2231/32620130101 , B01J2231/421120130101
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公开(公告)号：EP4339192A3
公开(公告)日：2024-06-19
申请号：EP23199886.5
申请日：2017-06-28
发明人： PETO, Csaba , TOLANI, Bhairavi , WOODARD, Gavitt , TSANG, Tsze , MANN, Michael , JABLONS, David M. , HE, Biao
IPC分类号： A61K31/4155 , A61K31/4439 , C07D231/06 , A61K31/415 , A61P19/04
CPC分类号： C07D231/06 , C07D403/12 , C07D405/14 , C07D413/14 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D493/04 , C07D495/04 , C07D498/04 , C07D498/10 , A61P19/04 , A61P35/00 , A61P43/00
摘要： The present disclosure provides compounds, pharmaceutical compositions, and methods for the treatment of cancer and fibrosis. The disclosed pharmaceutical compositions may include one of more pyrazolyl-containing compounds, or a derivative thereof.
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公开(公告)号：EP3842421B1
公开(公告)日：2024-06-12
申请号：EP21158419.8
申请日：2015-03-20
IPC分类号： C07C45/68 , C07D215/38 , C07B37/04 , C07B43/04 , C07F15/00 , C07D401/06 , C07D403/04 , C07C17/32 , C07D213/127 , C07D213/24 , C07D213/50 , C07D213/56 , C07D295/096 , C07D307/46 , C07D405/04 , C07D409/04 , C07D471/04
CPC分类号： C07D215/38 , C07B37/04 , C07B43/04 , C07D401/06 , C07D403/04 , C07D405/04 , C07D409/04 , C07D471/04 , C07D295/096 , C07D213/127 , C07D213/24 , C07D213/50 , C07D213/56 , C07D307/46 , C07C45/68 , C07C17/32 , C07F15/006
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公开(公告)号：EP4364569A3
公开(公告)日：2024-06-05
申请号：EP24165645.3
申请日：2021-01-29
申请人： FMC Corporation
发明人： AHMAD, Omar Khaled , BRIDDELL, Twyla A. , CHAN, Dominic Ming-Tak , CHEN, Yuzhong , HAMM, Jason Charles , KAR, Moumita , PAHUTSKI, Thomas Francis Jr. , STEVENSON, Thomas Martin , XU, Ming , SLACK, Rachel
IPC分类号： C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D413/04 , A01N43/40 , A01N43/50 , A01N43/54 , A01N43/56 , A01N43/647 , A01N43/76 , A01N43/78 , A01N43/80 , A01N43/82
CPC分类号： C07D401/04 , C07D401/14 , C07D405/04 , C07D405/14 , C07D413/04 , C07D409/04 , A01N43/56 , A01N43/647 , A01N43/54 , A01N43/40 , A01N43/50 , A01N43/76 , A01N43/78 , A01N43/82 , A01N43/80
摘要： Disclosed are compounds of Formula 1, including all geometric and stereoisomers, N-oxides, and salts thereof,
wherein
R1, A, R2, R4, R5 and Q are as defined in the disclosure.
Also disclosed are compositions containing the compounds of Formula 1 and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a compound or a composition of the disclosure.
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