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18 条记录 (耗时 0.019 秒)

    GENOMICS OF ACTINOPLANES UTAHENSIS
    7.
    发明公开
    GENOMICS OF ACTINOPLANES UTAHENSIS 有权
    GENOMIK VON ACTINOPLANES UTAHENSIS

    公开(公告)号：EP2601209A1

    公开(公告)日：2013-06-12

    申请号：EP11741187.6

    申请日：2011-08-01

    申请人： Bayer Intellectual Property GmbH

    发明人： SELBER, Klaus ,  WEINGÄRTNER, Bernhard ,  WEHLMANN, Hermann ,  ROSEN, Winfried ,  PÜHLER, Alfred ,  SCHWIENTEK, Patrick ,  KALINOWSKI, Jörn ,  WEHMEIER, Udo

    IPC分类号： C07K14/365 ,  C12N15/11 ,  C12P19/26

    CPC分类号： C12N1/20 ,  C07K14/365 ,  C12P19/26

    摘要： The present invention describes the DNA-sequence of the wild type genome as well as all genetic modifications which were introduced into the wild type-and further developed strains, based thereon. Thereby the first genotypic characterization of the developed strains, including the latest production strain, has been accomplished, accounting for the major part of the invention. Furthermore, on the basis of the determined DNA-sequences, potential genes were identified and account, combined with their functional annotation, for another part of the invention. In particular, the gene-and DNA-sequences, as well as protein- sequences derived there out, contribute to the invention which were affected by mutagenic modifications throughout the strain development process, potentially contributing to the increased production yield.

    摘要翻译： 本发明描述了野生型基因组的DNA序列以及基于其引入野生型和进一步开发的菌株的所有遗传修饰。 因此，已经完成了包括最新生产菌株在内的开发菌株的第一个基因型表征，这是本发明的主要部分。 此外，在确定的DNA序列的基础上，鉴定潜在的基因并结合其功能性注释与本发明的另一部分相结合。 特别地，基因和DNA序列以及从那里导出的蛋白质序列有助于在整个应变开发过程中受诱变修饰影响的本发明，潜在地有助于提高产量。

    CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONE (PTH) ANALOGS
    9.
    发明公开
    CONFORMATIONALLY CONSTRAINED PARATHYROID HORMONE (PTH) ANALOGS 有权
    甲状旁腺激素（PTH）类似物有限公司构

    公开(公告)号：EP1439854A2

    公开(公告)日：2004-07-28

    申请号：EP02778189.7

    申请日：2002-07-19

    申请人： THE GENERAL HOSPITAL CORPORATION

    发明人： THE GENERAL HOSPITAL CORPORATION

    IPC分类号： A61K38/29 ,  A61P5/18 ,  C07K14/365

    CPC分类号： C07K14/635 ,  A61K38/00

    摘要： The present invention relates to conformationally constrained parathyroid hormone (PTH) analogs, and methods of preparing and using the PTH analogs. The invention provides novel PTH polypeptide derivatives containing amino acid substitutions at selected positions in the polypeptides. The invention provides derivatives of PTH (1-34), PTH(1-21), PTH(1-20), PTH(1-19), PTH(1-18), PTH(1-17), PTH(1-16), PTH(1-15), PTH(1-14), PTH(1-13), PTH(1-12), PTH(1-11) and PTH(1-1 0) polypeptides, wherein at least one residue in each polypeptide is a helix, preferably an a-helix, stabilizing residue. The invention also provides methods of making such peptides. Further, the invention encompasses compositions and methods for use in limiting undesired bone loss in a vertebrate at risk of such bone loss, in treating conditions that are characterized by undesired bone loss or by the need for bone growth, e.g. in treating fractures or cartilage disorders and for raising cAMP levels in cells where deemed necessary.