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公开(公告)号：EP1461434A2
公开(公告)日：2004-09-29
申请号：EP02787310.8
申请日：2002-12-24
IPC分类号： C12N15/52
摘要： The invention relates to isolated polypeptides involved in lipopeptide biosynthesis and polynucleotides encoding such polypeptides. In particular, the isolated polypeptide may be an acyl-specific C-domain, an adenylating enzyme, or an acyl carrier. The invention also relates to methods for detecting a polypeptide involved in lipopeptide biosynthesis or a polynucleotide encoding such a polypeptide, as well as relevant useful computer readable medium and computer systems.
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公开(公告)号：EP1458868A2
公开(公告)日：2004-09-22
申请号：EP02787309.0
申请日：2002-12-24
摘要： Genes and proteins involved in the biosynthesis of lipopeptides by microorganisms, in particular the nucleic acids forming the biosynthetic locus for the A54145 lipopeptide from Streptomyces fradiae and the A54145-like lipopeptide from Streptomyces refuineus. These nucleic acids can be used to make expression constructs and transformed host cells for the production of lipopeptides. The genes and proteins allow direct manipulation of lipopeptides and related chemical structures via chemical engineering of the proteins involved in the biosynthesis of A54145.
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公开(公告)号：EP1409686B1
公开(公告)日：2006-03-22
申请号：EP02750735.9
申请日：2002-07-26
摘要： Genes and proteins involved in the biosynthesis of macrolides by microorganisms, in particular the nucleic acids forming the biosynthetic locus for the 16-member macrolide rosaramicin from Micromonospora carbonacea. These nucleic acids can be used to make expression constructs and transformed host cells for the production of rosaramicin. The genes and proteins allow direct manipulation of macrolides and related chemical structures via chemical engineering of the proteins involved in the biosynthesis of rosaramicin.
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公开(公告)号：EP1381685B1
公开(公告)日：2005-09-14
申请号：EP02724065.4
申请日：2002-04-26
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5.发明公开GENES AND PROTEINS INVOLVED IN THE BIOSYNTHESIS OF ENEDIYNE RING STRUCTURES 审中-公开基因和蛋白相对于烯二炔环系结构生物合成
公开(公告)号：EP1390507A2
公开(公告)日：2004-02-25
申请号：EP02729707.6
申请日：2002-05-21
摘要： Five protein families cooperate to form the warhead structure that characterizes enediyne compounds, both chromoprotein enediynes and non-chromoprotein enediynes. The protein families include a polyketide synthase and thioesterase protein which form a polyketide synthase catalytic complex involved in warhead formation in enediynes. Genes encoding a member of each of the five protein families are found in all enediyne biosynthetic loci. The genes and proteins may be used in genetic engineering applications to design new enediyne compounds and in methods to identify new enediyne biosynthetic loci.
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6.发明公开METHOD, SYSTEM AND KNOWLEDGE REPOSITORY FOR IDENTIFYING A SECONDARY METABOLITE FROM A MICROORGANISM 审中-公开方法，系统和WISSENSSPEICHER二次代谢产物OFA微生物的检测
公开(公告)号：EP1470241A2
公开(公告)日：2004-10-27
申请号：EP03731645.2
申请日：2003-01-24
发明人： FARNET, Chris, M. , MCALPINE, James, B. , BACHMANN, Brian, O. , ZAZOPOULOS, Emmanuel , STAFFA, Alfredo , ZHAO, Zhizi , WONG, Sai, Man , DESJARDINS, Nicolas
CPC分类号： C12Q1/025
摘要： The invention relates to a method and system for identifying a secondary metabolite synthesized by a target gene cluster within a microorganism. A putative or confirmed function is attributed to a gene within the gene cluster, and an extract from the microorganism is obtained which is suspected to contain the secondary metabolite synthesized by the gene cluster. The extract is then assessed for chemical, physical or biological properties, and the metabolite is identified and optionally isolated. Further, the invention provides a knowledge repository in which gene cluster information is linked to secondary metabolite production data. The invention further relates to a graphical user interface for accessing the knowledge repository, and a memory for storing data, having a data structure that is stored in the memory.
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公开(公告)号：EP1409686A2
公开(公告)日：2004-04-21
申请号：EP02750735.9
申请日：2002-07-26
摘要： Genes and proteins involved in the biosynthesis of macrolides by microorganisms, in particular the nucleic acids forming the biosynthetic locus for the 16-member macrolide rosaramicin from Micromonospora carbonacea. These nucleic acids can be used to make expression constructs and transformed host cells for the production of rosaramicin. The genes and proteins allow direct manipulation of macrolides and related chemical structures via chemical engineering of the proteins involved in the biosynthesis of rosaramicin.
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公开(公告)号：EP1326983A2
公开(公告)日：2003-07-16
申请号：EP01980080.4
申请日：2001-10-15
IPC分类号： C12N15/31 , C12N15/52 , C12N9/00 , C07K14/365 , C12P21/00
CPC分类号： C07K14/365 , C12N15/52
摘要： The present invention relates to isolated genetic sequences encoding proteins which direct the biosynthesis of the antibiotic ramoplanin in microorganisms. The isolated biosynthetic gene cluster serves as a substrate for bioengineering of antibiotic structures.
摘要翻译： 本发明涉及编码在微生物中指导抗生素ramoplanin生物合成的蛋白质的分离的遗传序列。 分离的生物合成基因簇用作抗生素结构生物工程的底物。
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公开(公告)号：EP1326983B1
公开(公告)日：2005-04-06
申请号：EP01980080.4
申请日：2001-10-15
IPC分类号： C12N15/31 , C12N15/52 , C12N9/00 , C07K14/365 , C12P21/00
CPC分类号： C07K14/365 , C12N15/52
摘要： The present invention relates to isolated genetic sequences encoding proteins which direct the biosynthesis of the antibiotic ramoplanin in microorganisms. The isolated biosynthetic gene cluster serves as a substrate for bioengineering of antibiotic structures.
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公开(公告)号：EP1381685A2
公开(公告)日：2004-01-21
申请号：EP02724065.4
申请日：2002-04-26
摘要： Genes and proteins involved in the biosynthesis of polyketides by microorganisms, including the genes and proteins forming the biosynthetic loci for the polyketide dorrigocin from Streptomyces platensis subsp. rosaceus and the polyketide lactimidomycin from Streptomyces amphibiosporus. The genes and proteins allow direct manipulation of dorrigocin, lactimidomycin and related chemical structures via chemical engineering of the enzymes involved in the biosynthesis of dorrigocin and lactimidomycin.
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