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公开(公告)号：EP3864144A1
公开(公告)日：2021-08-18
申请号：EP19791437.7
申请日：2019-10-08
申请人： Intrexon Corporation
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2.发明授权PROCESS FOR THE SELECTIVE REDUCTION OF BILE ACIDS, THEIR SALTS OR DERIVATIVES, IN A BIPHASIC SYSTEM 有权PROCESS FOR IN A 2相体系胆汁酸，它们的盐和衍生物的选择性还原
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3.发明公开LEVURES MODIFIEES ET UTILISATIONS, NOTAMMENT POUR LA PRODUCTION DE DERIVES STEROIDIENS 有权修饰细胞及其用途，特别是对甾类衍生物生产
公开(公告)号：EP1313873A1
公开(公告)日：2003-05-28
申请号：EP01956637.1
申请日：2001-07-24
申请人： Aventis Pharma S.A.
发明人： DUMAS, Bruno , CAUET, Gilles , ACHSTETTER, Tilman , DEGRYSE, Eric
CPC分类号： C12N9/0087 , C12P33/06
摘要： The invention concerns novel yeast strains, methods and genetic constructs for preparing them, and their use for synthesising or modifying steroid compounds. More particularly, the invention concerns strains having reduced 20α-HSD activity, in particular by modification of the GCY1 and/or YPR1 genes. The inventive yeast strains enable to improve the efficacy of synthesis or to increase selectivity or yields of the process, as well as the quality of the final product. The inventive strains, methods and compounds are useful for researching, developing and producing products with therapeutic or prophylactic activity, in a human or an animal, in particular steroid derivatives.
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4.发明授权A microbiological process for the transformation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase 失效为的17-β-羧基取代-3-氧代-4- azasteroids改造和使用此类产品的作为酶5-α-还原酶的抑制剂微生物法
公开(公告)号：EP0922770B1
公开(公告)日：2002-09-18
申请号：EP98124126.8
申请日：1995-10-10
CPC分类号： C07J73/005 , C12P33/02
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5.发明公开A microbiological process for the transformation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase 失效用于转化17β-羧基取代的3-氧代-4-氮杂甾体的微生物学方法以及作为酶抑制剂的5α-还原酶
公开(公告)号：EP0922770A3
公开(公告)日：1999-06-30
申请号：EP98124126.8
申请日：1995-10-10
IPC分类号： C12P33/06
CPC分类号： C07J73/005 , C12P33/02
摘要： The present invention relates to a microbiological process for the transformation of 17β-substituted 4-azaandrostan-3-ones and the use of the biotransformation products as inhibitors of the enzyme 5α-reductase.
摘要翻译： 本发明涉及用于转化17β-取代的4-氮杂雄甾烷-3-酮的微生物学方法以及生物转化产物作为酶5α-还原酶的抑制剂的用途。
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6.发明公开A microbiological process for the transformation of 17beta-carboxy substituted 3-oxo-4-azasteroids and the use of such products as inhibitors of the enzyme 5alpha-reductase 失效为的17-β-羧基取代-3-氧代-4- azasteroids改造和使用此类产品的作为酶5-α-还原酶的抑制剂微生物法
公开(公告)号：EP0922770A2
公开(公告)日：1999-06-16
申请号：EP98124126.8
申请日：1995-10-10
IPC分类号： C12P33/06
CPC分类号： C07J73/005 , C12P33/02
摘要： The present invention relates to a microbiological process for the transformation of 17β-substituted 4-azaandrostan-3-ones and the use of the biotransformation products as inhibitors of the enzyme 5α-reductase.
摘要翻译： 本发明涉及一种微生物处理为17的β转变取代4- azaandrostan -3-酮和使用生物转化产品的作为酶5α还原酶的抑制剂。
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7.发明授权
公开(公告)号：EP0391503B1
公开(公告)日：1994-06-15
申请号：EP90201279.8
申请日：1988-02-05
CPC分类号： C12P33/06 , C07J7/002 , C07J7/0045
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8.发明授权NOVEL ANDROST-4-ENE-3,17-DIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 失效新型安慰剂4-ENE-3,17二酮衍生物及其制备方法
公开(公告)号：EP0300062B1
公开(公告)日：1992-07-29
申请号：EP88901462.7
申请日：1988-02-05
发明人： YOSHIHAMA, Makoto , TAMURA, Koji 2-D, Matsubara Manshon , MIYATA, Nobuo , NAKAYAMA, Shoji , NAKAKOSHI, Masamichi
CPC分类号： C07J1/0011 , C12P33/06
摘要： Compounds of formula (I), wherein X represents =O or H(alpha)OR(beta), Y represents H2 or OH(alpha)H(beta), Z represents H or OH(alpha), and R represents H, COCH3, COCH2CH3, COCH(CH3)2 or COC(CH3)3, which are prepared by bringing androst-4-ene-3,17-dione into contact with microorganisms belonging to the genus Acremonium. These compounds are effective in inhibiting estrogen synthetase of human placenta origin.
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9.发明公开
公开(公告)号：EP0391503A3
公开(公告)日：1991-01-30
申请号：EP90201279.8
申请日：1988-02-05
CPC分类号： C12P33/06 , C07J7/002 , C07J7/0045
摘要： 7β-hydroxy-4-pregnene-3,20-dione derivatives are prepared by use of Acremonium sp. The group of these compounds has possibility of being utilized as an intermediate for the synthesis of progesterone derivatives having ovulation-inhibiting activity. These compounds themselves have also cell differentiaition activity for Ml cells.
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10.发明公开NOVEL ANDROST-4-ENE-3,17-DIONE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. 失效新雄-4-烯-3,17-二酮衍生物及其制造方法。
公开(公告)号：EP0300062A4
公开(公告)日：1989-03-21
申请号：EP88901462
申请日：1988-02-05
发明人： YOSHIHAMA MAKOTO , TAMURA KOJI -D MATSUBARA MANSH , MIYATA NOBUO , NAKAYAMA SHOJI , NAKAKOSHI MASAMICHI
IPC分类号： A61K31/565 , C07J1/00 , C12P33/06
CPC分类号： C07J1/0011 , C12P33/06
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