公开(公告)号：EP2622097A2

公开(公告)日：2013-08-07

申请号：EP11779491.7

申请日：2011-09-25

申请人： MOR RESEARCH APPLICATIONS LTD.

发明人： AVIGAD, Smadar ,  YANIV, Isaac

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

摘要： The present invention relates to prognostic methods and kits for the assessment and monitoring of relapse-free or disease-free survival of ALL patients. The detection is based on the use of detecting nucleic acids, specific for determination of the expression of at least one of miR-151-5p and miR-451 in a test sample. The invention thereby also provides methods and kits for monitoring and early diagnosis of cancerous disorders associated with low miR-151-5p and/or miR-451 expression, specifically ALL.

公开(公告)号：EP2595991A2

公开(公告)日：2013-05-29

申请号：EP11809371.5

申请日：2011-07-19

申请人： Ben Gurion University of The Negev Research And Development Authority ,  MOR RESEARCH APPLICATIONS LTD.

发明人： GOLAN, Avi ,  GOPAS, Jacob ,  OZER, Janet ,  EISNER, Nadav ,  BACHER, Adelbert ,  EISENREICH, Wolfgang ,  OSTROZHENKOVA, Elena ,  WINER, Hila

IPC分类号： C07D495/00 ,  C07D495/22

CPC分类号： A61K31/438 ,  A61K31/4747 ,  A61K31/7048 ,  A61K33/24 ,  A61K36/62 ,  A61K2300/00

摘要： The current invention provides therapeutic methods which include inhibition of nuclear factor κb pathway in a cell based on the discovery of an active fraction of a plant extract termed NUP or a composition which includes NUP. NUP is used in treating and managing different diseases such as cancer, inflammation, and virus infections.

公开(公告)号：EP2483824A1

公开(公告)日：2012-08-08

申请号：EP10763452.9

申请日：2010-08-24

申请人： MOR RESEARCH APPLICATIONS LTD.

发明人： ATLAS, Eran ,  NIMRI, Revital ,  MILLER, Shahar ,  GRUNBERG, Eli Aviram ,  PHILLIP, Moshe

IPC分类号： G06F19/00

CPC分类号： G06F19/3468 ,  A61B5/14532 ,  A61M5/1723 ,  A61M2005/14208 ,  A61M2230/201 ,  G06F19/00 ,  G06N7/00 ,  G16H50/20

摘要： Monitoring system and method for use with diabetic treatment management. The system includes: a communication interface configured to permit access to stored raw log data, obtained over a certain time, being indicative of glucose measurements, meals consumed and insulin delivery; and a control unit including an unsupervised learning controller configured to receive and process said raw log data and determine at least one global insulin pump setting of basal rate, correction factor, carbohydrate ratio and insulin activity curve parameters. The system may include a processing unit including a first processor for processing measured data indicative of blood glucose level and generating first processed data, a second processor including at least one fuzzy logic module which receives input parameters corresponding to the measured data, the first processed data and a reference data, and processes the data to produce a qualitative output parameter to determine whether any treatment parameter should be modified.

摘要翻译： 用于糖尿病治疗管理的监测系统和方法。 该系统包括：通信接口，被配置为允许访问在一定时间内获得的存储的原始日志数据，其指示葡萄糖测量值，膳食消耗量和胰岛素递送; 以及控制单元，其包括无监督学习控制器，其被配置为接收和处理所述原始对数数据并且确定基础速率，校正因子，碳水化合物比率和胰岛素活性曲线参数的至少一个全局胰岛素泵设置。 该系统可以包括处理单元，该处理单元包括第一处理器，用于处理指示血糖值的测量数据并产生第一处理数据;第二处理器，包括至少一个模糊逻辑模块，其接收对应于测量数据的输入参数，第一处理数据 和参考数据，并处理数据以产生定性输出参数，以确定是否应修改任何治疗参数。

公开(公告)号：EP1469869B1

公开(公告)日：2011-09-14

申请号：EP02775191.6

申请日：2002-10-15

申请人： Cure Tech Ltd. ,  MOR-RESEARCH APPLICATIONS LTD.

发明人： HARDY, Britta ,  RAITER, Annat ,  KLAPPER, Leah

IPC分类号： A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： C07K7/08 ,  A61K38/00 ,  A61K39/00 ,  C07K16/28 ,  C07K2317/34

摘要： The present invention provides peptides and polynucleotides, and their use for immunomodulation, immunotherapy and vaccine particularly for anti-cancer therapy, and for diagnosis purposes. The immunomodulatory effect includes induction of proliferation and activation of peripheral blood lymphocytes and induction of an anti-tumor effect upon administration of peptides of the invention to subjects suffering from cancer.

公开(公告)号：EP2012825A2

公开(公告)日：2009-01-14

申请号：EP07736161.6

申请日：2007-03-29

申请人： Ben-Gurion University of the Negev Research and Development Authority ,  Mor-Research Applications Ltd.

发明人： MIZRACHI NEBENZAHL, Yaffa ,  DAGAN, Ron

IPC分类号： A61K39/40

CPC分类号： C07K16/1275 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/40 ,  G01N2333/315

摘要： A method of preventing and/or treating S. pneumoniae infection in mammalian subjects, wherein said method comprises administering to said subjects a composition comprising one or more agents that are capable of inhibiting the binding of the S. pneumoniae cell wall protein FBA to the respiratory tract cells of said subject.

公开(公告)号：EP1172654B1

公开(公告)日：2007-10-31

申请号：EP00114788.3

申请日：2000-07-10

申请人： Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts ,  MOR RESEARCH APPLICATIONS LTD.

发明人： Altevogt, Peter ,  Fogel, Mina

IPC分类号： G01N33/574 ,  G01N33/68 ,  A61K39/395 ,  A61K38/17 ,  G01N33/577

CPC分类号： G01N33/57449 ,  G01N33/57442 ,  G01N2333/70503 ,  G01N2333/70596

公开(公告)号：EP1641940A2

公开(公告)日：2006-04-05

申请号：EP04744918.6

申请日：2004-06-30

申请人： MOR RESEARCH APPLICATIONS LTD.

发明人： AVIGAD, Smadar ,  YANIV, Isaac ,  ZAIZOV, Rina ,  OHALI, Anat

IPC分类号： C12Q1/68 ,  C12P19/34 ,  C07H21/02

CPC分类号： C12Q1/6886 ,  C12Q2600/118

摘要： The present invention provides a method for assessing the prognosis of Ewing's Sarcoma patients comprising determining the expression pattern of a defined set of genes in tumor material obtained from said patients, and assigning said expression pattern to either a good prognosis or poor prognosis group.

公开(公告)号：EP1575484A2

公开(公告)日：2005-09-21

申请号：EP03723038.0

申请日：2003-05-22

申请人： Cure Tech Ltd. ,  MOR-RESEARCH APPLICATIONS LTD.

发明人： HARDY, Britta ,  JONES, Steven Tarran ,  KLAPPER, Leah

IPC分类号： A61K6/00

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/73

摘要： The present invention provides to a humanized monoclonal antibody having immunostimulatory effects. This antibody binds specifically to B lymphoblastoid cells, induces proliferation and activation of peripheral blood lymphocytes, and is capable of eliciting an anti-tumor effect upon administration to subjects suffering from cancer.

公开(公告)号：EP1494698A2

公开(公告)日：2005-01-12

申请号：EP03744970.9

申请日：2003-03-26

申请人： Ben-Gurion University of The Negev ,  MOR RESEARCH APPLICATIONS LTD.

发明人： NATHAN, Ilana ,  LICHTENSTEIN, Alexandra

IPC分类号： A61K38/00

CPC分类号： A61K38/55 ,  A61K8/64 ,  A61K31/00 ,  A61K38/07 ,  A61K38/1761 ,  A61Q19/08 ,  A61K2300/00

摘要： A method for treating and/or preventing cell necrosis and diseases associated therewith, comprising the inhibition of one or more elastase enzymes within said cells.

公开(公告)号：EP0973389A1

公开(公告)日：2000-01-26

申请号：EP98911573.8

申请日：1998-03-11

申请人： BAR-ILAN UNIVERSITY ,  MOR RESEARCH APPLICATIONS LTD.

发明人： NUDELMAN, Abraham ,  REPHAELI, Ada

IPC分类号： A01N37/10 ,  A01N55/02 ,  C07C229/00 ,  C07D211/78

CPC分类号： C07D213/79 ,  C07C229/60 ,  C07C233/54 ,  C07D211/70 ,  C07D213/55

摘要： This invention relates to compositions for and methods of treating, preventing or ameliorating cancer and other proliferative diseases as well as methods of inducing wound healing, treating cutaneous ulcers, treating gastrointestinal disorders, treating blood disorders such as anemias, immunomodulation, enhancing recombinant gene expression, treating insulin-dependent patients, treating cystic fibrosis patients, inhibiting telomerase activity, treating virus-associated tumors, especially EBV-associated tumors, modulating gene expression and particularly augmenting expession of tumor suppressor genes, inducing tolerance to antigens, treating, preventing or ameliorating protozoan infection or inhibiting histone deacetylase in cells. The compositions of the invention are to and the methods of the invention use nitrogen-containing oxyalkyl esters.