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公开(公告)号：EP0953054B1
公开(公告)日：2004-08-04
申请号：EP97949050.5
申请日：1997-12-12
发明人： MARKHAM,Alexander, Fred, The University of Leeds , MEREDITH, David, Mark, The University of Leeds
CPC分类号： C12N15/86 , C12N2710/16721 , C12N2710/16743
摘要： The invention relates to manipulation of equine herpes virus for use in gene therapy and in particular to modifications of the virus so that it can carry heterologous material and furthermore, preferably, be replication deficient so that the virus cannot replicate in the target tissue.
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公开(公告)号：EP1412506A2
公开(公告)日：2004-04-28
申请号：EP02745659.9
申请日：2002-07-19
发明人： BAKER, Alison,Leeds Institute for Biotechnolgy & , SLOCOMBE, Stephen,Leeds Institute for , GRAHAM, IanCentre for Novel Agricultural Products
IPC分类号： C12N15/82
CPC分类号： C07K14/415 , C12N15/8209 , C12N15/8247
摘要： A nucleic acid which encodes a peroxisomal fatty acid transporter, uses thereof and a method of genetic manipulation of peroxisomal fatty acid transport and/or Metabolism. The nucleic acid and its products are especially for use in regulation of peroxisomal fatty acid transport in plant and in controlling the spectrum of fatty acids which can be utilised by the plant.
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公开(公告)号：EP1231274A3
公开(公告)日：2002-10-09
申请号：EP02004082.0
申请日：1995-11-20
CPC分类号： C12N15/82 , A01N37/46 , A01N61/00 , C07K14/8139 , C07K2319/00 , C12N15/8242 , C12N15/8285 , Y02A40/164
摘要： The invention relates to proteinase inhibitors and in particular cystatins which have been modified so as to enhance their effective or synthetically manufactured counterpatrts. The modification including either site directed alterations in the structure of the protein and/or the production of hybrid molecules.
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公开(公告)号：EP1233707A2
公开(公告)日：2002-08-28
申请号：EP00985460.5
申请日：2000-12-04
发明人： Seedhom, Bahaa , Toyoda, Takashi , Pullan, Michael
IPC分类号： A61B17/16
CPC分类号： A61B17/1675 , A61B17/1604 , A61B17/1637 , A61B17/1659 , A61B17/32053 , A61B2017/00464 , A61B2017/00469 , A61B2017/1602 , A61B2017/320004 , A61B2017/320008 , A61B2017/320012 , A61B2090/08021 , A61F2/0063 , A61F2/0095 , A61F2/28 , A61F2/2846 , A61F2/30756 , A61F2/38 , A61F2/4618 , A61F2002/0086 , A61F2002/286 , A61F2002/30062 , A61F2002/30064 , A61F2002/30113 , A61F2002/30118 , A61F2002/30125 , A61F2002/30131 , A61F2002/30143 , A61F2002/3024 , A61F2002/30556 , A61F2002/30599 , A61F2002/30611 , A61F2002/30678 , A61F2002/30716 , A61F2002/30761 , A61F2002/30762 , A61F2002/30764 , A61F2002/3093 , A61F2002/3097 , A61F2002/4635 , A61F2210/0004 , A61F2230/0006 , A61F2230/0008 , A61F2230/0013 , A61F2230/0017 , A61F2230/0069 , A61F2250/0009 , A61F2250/0063 , A61F2250/009 , A61F2310/00341 , A61F2310/00359
摘要： The invention relates to a method for the repair of damaged tissue present at or on the surface (5, 27) of bone in an animal, the method comprising forming a narrow groove (7, 25) around at least part of said damaged tissue, which groove extends (7, 25) into the bone (3, 29) below the damaged tissue, replacing the tissue around which the groove (7, 25) extends by at least one layer of biocompatible replacement material (9), and anchoring the material (9) to the bone (3, 29) by the use of retaining means (11) extending from the material (9) into the groove (7, 25); instruments for use in the repair of damaged tissue and kits comprising said instruments.
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公开(公告)号：EP1231274A2
公开(公告)日：2002-08-14
申请号：EP02004082.0
申请日：1995-11-20
CPC分类号： C12N15/82 , A01N37/46 , A01N61/00 , C07K14/8139 , C07K2319/00 , C12N15/8242 , C12N15/8285 , Y02A40/164
摘要： The invention relates to proteinase inhibitors and in particular cystatins which have been modified so as to enhance their effective or synthetically manufactured counterpatrts. The modification including either site directed alterations in the structure of the protein and/or the production of hybrid molecules.
摘要翻译： 本发明涉及蛋白酶抑制剂，特别是已被修饰以增强其有效或合成制造的对手的胱氨酸蛋白酶。 修饰包括蛋白质结构中的位点定向改变和/或杂合分子的产生。
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96.发明公开THERAPEUTIC AGENTS COMPRISING AN E3 UBIQUITIN LIGASE FOR USE IN DEGENERATIVE DISORDERS 审中-公开E3泛素连接酶含治疗药退行性疾病的治疗
公开(公告)号：EP1135505A1
公开(公告)日：2001-09-26
申请号：EP99973071.6
申请日：1999-11-30
发明人： MARKHAM, Alexander Fred,Molecular Medicine Unit , ROBINSON, Philip Alan,Molecular Medicine Unit
摘要： An isolated nucleic acid molecule encoding an E2 associated protein, which acts in the role of an E3 ubiquitin ligase, wherein said isolated nucleic acid has a nucleotide sequence which hybridises to the nucleic acid shown in Figure 1. The invention also provides the polypeptide encoded by the nucleic acid and antibodies raised against the polypeptide.
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公开(公告)号：EP0939828A1
公开(公告)日：1999-09-08
申请号：EP97919133.0
申请日：1997-09-04
申请人： UNIVERSITY OF LEEDS
发明人： MEREDITH, David, Mark, The University of Leeds , MARKHAM, Alexander, Fred, The University of Leeds
CPC分类号： C12N15/86 , A61K38/00 , A61K48/00 , C07K14/005 , C12N2710/16422 , C12N2710/16443
摘要： The invention relates to a means to a herpesvirus saimiri that has been genetically modified by mutating and/or deleting specific essential and non-essential genes. The essential genes are required in replication of viral genes and are needed for viral proliferation. The non-essential genes can represent sites for the insertion of heterologous genetic material, namely therapeutic genes.
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98.发明公开RECOMBINANT PLANT CELLS EXPRESSING HETEROCHROMATIN 1 (HP1) OF DROSOPHILA MELANOGASTER 失效重组植物细胞异1（HP1）OFF果蝇黑腹果蝇表达
公开(公告)号：EP0939811A1
公开(公告)日：1999-09-08
申请号：EP97933800.0
申请日：1997-08-01
申请人： UNIVERSITY OF LEEDS
发明人： MEYER, Peter
CPC分类号： C07K14/43581 , C07K2319/00 , C12N15/8261 , C12N15/8271 , C12N15/8273 , Y02A40/146
摘要： A plant or plant cell containing the chromo domain of heterochromatin protein 1, ideally derived from the genus Drosophila, wherein said domain confers selective advantage on said plant or cell.
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公开(公告)号：EP0934145A2
公开(公告)日：1999-08-11
申请号：EP97943968.0
申请日：1997-10-06
IPC分类号： B29C43
CPC分类号： B29C43/006 , B29K2023/06 , B29K2023/12 , B29K2105/06 , B29K2223/06 , B29K2223/12
摘要： A polyolefin plaque is produced by hot compaction of an assembly of melt spun oriented fibres. It has been found that good compaction can be achieved at relatively low compaction pressures, less than 10 MPa. Compaction can be carried out in an autoclave, rather than in a hot compaction press, and the mechanical properties of plaques so produced range from good to excellent.
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公开(公告)号：EP0871752A1
公开(公告)日：1998-10-21
申请号：EP96940016.0
申请日：1996-11-28
CPC分类号： C12N15/8222 , C07K14/415 , C07K14/8139 , C12N15/8227 , C12N15/8285 , Y02A40/164
摘要： This invention relates to the control of pests. In particular the invention relates to the protection of plants against parasitic nematodes. The invention provides nucleic acid comprising a transcription initiation region capable of directing expression predominantly in the roots of a plant, and a sequence which encodes an anti-nematode protein.
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