公开(公告)号：EP3024844B1

公开(公告)日：2018-09-12

申请号：EP14829109.9

申请日：2014-07-24

申请人： The National Institute for Biotechnology in the Negev Ltd. ,  B.G. Negev Technologies & Applications Ltd., at Ben-Gurion University

发明人： SHOSHAN-BARMATZ, Varda

IPC分类号： C07K7/00 ,  C07K14/705 ,  C07K19/00 ,  A61K38/04 ,  A61P35/00

CPC分类号： C07K14/4747 ,  A61K38/00 ,  A61K47/645 ,  C07K14/43581 ,  C07K2319/00

摘要： The present invention relates to short peptides based on the amino acids sequence of the N-terminal domain of the human mitochondrial protein voltage-dependent anion channel 1 (VDAC) and to peptide conjugates having a cell permeability enhancing moiety. The peptides, peptide conjugates and pharmaceutical compositions containing them are useful for treating diseases characterized by cell hyperproliferation or resistance to cell death and in particular, cancer.

公开(公告)号：EP2253326B1

公开(公告)日：2018-04-04

申请号：EP09715976.8

申请日：2009-02-27

申请人： Toray Industries, Inc.

发明人： MORISHITA, Mariko ,  TAKAYAMA, Kozo ,  NISHIO, Reiji ,  IDA, Nobuo

IPC分类号： A61K38/21 ,  A61K38/28 ,  A61K38/10 ,  A61K47/42 ,  A61P43/00

CPC分类号： A61K38/215 ,  A61K9/0043 ,  A61K38/10 ,  A61K38/28 ,  A61K47/42 ,  C07K14/43581 ,  A61K2300/00

摘要： By a pharmaceutical composition for nasal administration comprising a hydrophilic bioactive substance and any one of (a) to (c) below, a hydrophilic bioactive substance having a low transmucosal absorption capability which has conventionally been able to be administered by only injection can be nasally administered. Such a pharmaceutical composition is useful for improvement of the pain and the inconvenience of patients caused by administration by injection. (a) A peptide having the amino acid sequence shown in SEQ ID NO: 1. (b) A peptide having the same amino acid sequence as shown in SEQ ID NO: except that one or several amino acids are deleted, substituted and/or added, the peptide having nasal mucosal permeability. (c) A peptide having an amino acid sequence represented by the reverse sequence of (a) or (b), the peptide having nasal mucosal permeability.

公开(公告)号：EP2289535B1

公开(公告)日：2018-03-28

申请号：EP10185372.9

申请日：2005-12-20

申请人： MEDICAL UNIVERSITY OF SOUTH CAROLINA

发明人： Gourdie, Robert ,  Ghatnekar, Gautam ,  Jourdan, Jane

IPC分类号： A61K38/08 ,  A61K38/10 ,  C07K5/10 ,  C07K7/06 ,  A61L31/08 ,  A61K45/06 ,  C07K14/435 ,  C07K14/47 ,  A61K38/07 ,  A61K38/17 ,  C07K7/08 ,  C07K14/705

CPC分类号： A61K38/177 ,  A61K38/07 ,  A61K38/08 ,  A61K38/10 ,  A61K38/1709 ,  A61K38/1767 ,  A61K45/06 ,  A61L31/08 ,  A61L2430/34 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  C07K14/43581 ,  C07K14/47 ,  C07K14/705 ,  C07K2319/01 ,  C07K2319/10

摘要： Provided herein are compositions and methods for use in promoting wound healing and tissue regeneration following tissue injury in a subject.

公开(公告)号：EP2478104A1

公开(公告)日：2012-07-25

申请号：EP10740638.1

申请日：2010-08-05

申请人： Fraunhofer Gesellschaft zur Förderung der angewandten Wissenschaft E.V.

发明人： SCHLEKER, Sylvia ,  PESCHEN, Dieter ,  FISCHER, Rainer ,  SCHILLBERG, Stefan

IPC分类号： C12N15/82 ,  C12N15/62 ,  C07K16/14 ,  C07K14/415 ,  A01H5/00

CPC分类号： C12N15/8282 ,  A01N63/00 ,  A01N63/02 ,  C07K14/43563 ,  C07K14/43581 ,  C07K14/46 ,  C07K16/14 ,  C07K2317/622 ,  C07K2319/00 ,  C07K2319/55 ,  C12N15/8258

摘要： The present invention relates to fusion proteins comprising anti-Oomycotic proteins or peptides linked to an antibody or fragment thereof specifically recognising an epitope of an
Oomycota . The invention is also directed to polynucleotides coding for the fusion proteins. The embodiments of the present invention are particularly useful for the protection of plants against
Oomycota . The invention therefore comprises transgenic plants expressing the fusion proteins of the present invention.

公开(公告)号：EP2463295A1

公开(公告)日：2012-06-13

申请号：EP11189808.6

申请日：2007-05-21

申请人： The Regents of The University of California

发明人： Cary, Stephen P.L. ,  Boon, Elizabeth M. ,  Weinert, Emily ,  Winger, Jonathan A. ,  Marletta, Michael A.

IPC分类号： C07K14/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/195 ,  C07K14/33 ,  C07K14/435 ,  C07K14/43545 ,  C07K14/43563 ,  C07K14/43581 ,  Y02A50/469 ,  Y02A50/471 ,  Y02A50/478 ,  Y10T436/102499

摘要： H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O 2 delivery. The engineered H-NOX proteins comprise mutations that impart altered O 2 or NO ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood O 2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of O 2 is beneficial.

摘要翻译： H-NOX蛋白被突变以表现出改善的或最佳的血液O2输送的动力学和热力学性质。 工程化的H-NOX蛋白质包含相对于相应的野生型H-NOX结构域赋予改变的O 2或NO配体结合的突变，并且作为生理上相容的哺乳动物血液O 2气体载体起作用。 本发明还提供了使用野生型或突变型H-NOX蛋白治疗O2递送有益的任何病症的药物组合物，试剂盒和方法。

公开(公告)号：EP2329026A2

公开(公告)日：2011-06-08

申请号：EP09809411.3

申请日：2009-08-20

申请人： Inis Biotech LLC ,  Fundacion Instituto Leloir ,  Consejo Nacional De Investigaciones Cientificas Y Tecnicas (Conicet)

发明人： CERIANI, Maria, Fernanda ,  REZAVAL, Carolina ,  BERNI, Jimena

IPC分类号： C12N15/12 ,  C12N15/00 ,  C12Q1/68

CPC分类号： C07K14/43581

摘要： A method for the identification of genes involved in neurodegenerative processes, detectable by the late onset of a phenotype associated with neurodegeneration, by means of a genetic screen of deregulated genes, which comprises the measurement of sleep-wake cycle activity schemes in different stages of life, young and adult, of individuals of an animal model, such as Drosophila. A mutant fly whose genome comprises a disruption in its enabled gene, with decrease of the enabled gene expression, and exhibiting a late onset neurodegenerative phenotype in adulthood.

公开(公告)号：EP2183277A1

公开(公告)日：2010-05-12

申请号：EP08789723.7

申请日：2008-07-30

申请人： Yissum Research Development Company of the Hebrew University of Jerusalem Ltd

发明人： APPLEBAUM, Shalom ,  HEIFETZ, Yael

IPC分类号： C07K14/435 ,  C12N15/12

CPC分类号： C07K14/43581

摘要： An isolated nucleic acid molecule comprising, or consisting of, a polynucleotide sequence encoding an oligopeptide capable of inducing post-mating depression of receptivity to mating in female insects, wherein said oligopeptide is resistant to proteolytic degradation, is provided for expression in sterile transgenic male insects useful in the control of insect populations.

公开(公告)号：EP2145897A3

公开(公告)日：2010-03-03

申请号：EP08007695.3

申请日：1993-09-30

申请人： Yale University

发明人： Artavanis-Tsakonas, Spyridon ,  Fehon, Richard Grant ,  Zagouras, Panayiotis ,  Blaumueller, Christine Marie

IPC分类号： C07K14/435 ,  A61K38/17 ,  A61K48/00 ,  C12N15/12

CPC分类号： A61K31/70 ,  A61K38/00 ,  C07K14/43581 ,  C07K14/47 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/20 ,  C07K2319/23 ,  C07K2319/70 ,  C07K2319/95 ,  C12N15/62 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57484 ,  G01N33/6893 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S436/815

摘要： The present invention relates to pharmaceutical compositions comprising a fragment of Serrate protein or a derivative or analog of said fragment, or comprising a derivative or analog of a Serrate protein, or comprising a protein comprising such a fragment, derivative or analog, the fragments, derivatives, analogs and proteins being characterized by the ability in vitro, when expressed on the surface of a first cell, to bind to a Notch protein expressed on the surface of a second cell. The invention also relates to chimeric proteins comprising said Serrate fragments joined via a peptide bond to a protein sequence of a protein different from the Serrate protein, and to nucleic acids encoding said fragments of a Serrate protein, and encoding said chimeric proteins. According to the invention, said fragments, derivatives, analogs, and proteins, said chimeric proteins and said nucleic acids may be used as a medicament, for example, in treating or preventing malignancy in a subject.

公开(公告)号：EP2032156A4

公开(公告)日：2009-11-11

申请号：EP07795174

申请日：2007-05-21

申请人： UNIV CALIFORNIA

发明人： CARY STEPHEN P L ,  BOON ELIZABETH M ,  WEINERT EMILY ,  WINGER JONATHAN A ,  MARLETTA MICHAEL A

IPC分类号： C07K14/00

CPC分类号： C07K14/47 ,  A61K38/00 ,  C07K14/195 ,  C07K14/33 ,  C07K14/435 ,  C07K14/43545 ,  C07K14/43563 ,  C07K14/43581 ,  Y10T436/102499

摘要： H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O 2 delivery. The engineered H-NOX proteins comprise mutations that impart altered O 2 or NO ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood O 2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of O 2 is beneficial.

公开(公告)号：EP1197220A3

公开(公告)日：2009-04-15

申请号：EP01120662.0

申请日：1993-09-30

申请人： Yale University

发明人： Artavanis-Tsakonas, Dr. ,  Fehon, Richard Grant ,  Zagouras, Panayiotis ,  Blaumüller, Christine Marie, Dr.

IPC分类号： A61K38/16 ,  A61K48/00 ,  C07K14/705 ,  C12N15/12 ,  C07K19/00 ,  A61P35/00

CPC分类号： A61K31/70 ,  A61K38/00 ,  C07K14/43581 ,  C07K14/47 ,  C07K14/705 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/20 ,  C07K2319/23 ,  C07K2319/70 ,  C07K2319/95 ,  C12N15/62 ,  G01N33/57411 ,  G01N33/57415 ,  G01N33/57419 ,  G01N33/57484 ,  G01N33/6893 ,  Y10S436/811 ,  Y10S436/813 ,  Y10S436/815

摘要： The present invention relates to pharmaceutical compositions comprising a fragment of a Delta protein or a derivative or analog of said fragment, or comprising a derivative or analog of a Delta protein, or comprising a protein comprising such a fragment, derivative or analog, the fragments, derivatives, analogs and proteins being characterized by the ability in vitro, when expressed on the surface of a first cell, to bind to a second protein expressed on the surface of a second cell, which second protein is a Notch protein or a second Delta protein. The invention also relates to chimeric proteins comprising said Delta fragments joined via a peptide bond to a protein sequence of a protein different from the Delta protein, and to nucleic acids encoding said fragments of a Delta protein, and encoding said chimeric proteins. According to the invention, said fragments, derivatives, analogs and proteins, said chimeric proteins and said nucleic acids may be used as a medicament, for example, in treating or preventing malignancy in a subject.