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公开(公告)号：EP1140083A1
公开(公告)日：2001-10-10
申请号：EP00902353.2
申请日：2000-01-07
IPC分类号： A61K31/444 , C07D213/22
CPC分类号： C07D401/04
摘要： Novel pyridin-4-yl or pyrimidin-4-yl substituted pyridine compounds and compositions for use in therapy.
摘要翻译： 新的吡啶-4-基或嘧啶-4-基取代的吡啶化合物和用于治疗的组合物。
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公开(公告)号：EP1135135A1
公开(公告)日：2001-09-26
申请号：EP99969337.7
申请日：1999-09-17
发明人： GILMARTIN, Aidan, G. , HO, Maureen, L. , IMBURGIA, Christina, S. , ROSHAK, Amy, K. , LAGO, Maria, Amparo
IPC分类号： A61K31/55
CPC分类号： A61K31/553
摘要： Methods of using chk1 kinase receptor antagonists are provided.
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公开(公告)号：EP1112070A1
公开(公告)日：2001-07-04
申请号：EP99942232.2
申请日：1999-08-17
发明人： ADAMS, Jerry, L. , LEE, Dennis
IPC分类号： A61K31/34 , A61K31/35 , A61K31/40 , A61K31/405 , A61K31/41 , A61K31/415 , A61K31/42 , A61K31/425 , A61K31/435 , A61K31/44 , A61K31/445 , A61K31/47 , A61K31/495 , A61K31/505 , A61K31/535 , C07D207/08 , C07D207/09 , C07D207/12 , C07D207/14 , C07D209/04 , C07D209/08
CPC分类号： C07D401/04 , B82Y15/00 , C07D403/04
摘要： Novel substituted triazole compounds and compositions for use in therapy as CSBP/p38 kinase inhibitors.
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公开(公告)号：EP1102535A2
公开(公告)日：2001-05-30
申请号：EP99937586.8
申请日：1999-07-28
CPC分类号： C07D213/82 , C07D213/56 , C07D249/04 , C07D307/68 , C07D311/66 , C07D333/24 , C07D333/38 , C07D401/04 , C07D405/04 , C07D409/04 , C07D417/04 , C07D417/14
摘要： This invention relates to substituted heteroanilide compounds which are modulators, agonists or antagonists, of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CCR5.
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公开(公告)号：EP1100495A1
公开(公告)日：2001-05-23
申请号：EP99937585.0
申请日：1999-07-28
IPC分类号： A61K31/34 , A61K31/38 , A61K31/40 , A61K31/42 , A61K31/44 , A61K31/47 , A61K31/135 , A61K31/405 , C07C211/00 , C07D211/06 , C07D491/107
CPC分类号： C07D207/08 , A61K31/167 , A61K31/341 , A61K31/343 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/404 , A61K31/4045 , A61K31/423 , A61K31/438 , A61K31/445 , A61K31/47 , A61K31/538 , C07B2200/09 , C07C233/29 , C07C233/44 , C07C235/38 , C07C255/57 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D209/08 , C07D263/58 , C07D265/28 , C07D295/088 , C07D491/10
摘要： This invention relates to substituted anilides which are modulators, agonists or antagonists, of the CCR5 receptor. In addition, this invention relates to the treatment and prevention of disease states mediated by CCR5.
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公开(公告)号：EP1087661A1
公开(公告)日：2001-04-04
申请号：EP99928764.2
申请日：1999-06-17
IPC分类号： A01N43/38 , A01N43/80 , A61K31/42 , A61K31/405
CPC分类号： A61K31/428 , Y02A50/411
摘要： This invention relates to novel compounds of Formula (I), and compositions thereof, useful in the treatment of disease states mediated by the chemokine, Interleukin-8 (IL-8).
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97.发明公开HERPES SIMPLEX VIRUS ORIGIN BINDING PROTEIN N-TERMINAL TRUNCATION (OBP-NT) 审中-公开单纯疱疹病毒的N端GAP PRODUC ORIGIN结合蛋白（OBP NT）
公开(公告)号：EP1086252A1
公开(公告)日：2001-03-28
申请号：EP99927441.8
申请日：1999-06-10
CPC分类号： C07K14/005 , A61K39/00 , C12N2710/16622
摘要： The invention provides herpes virus OBP-NT polypeptides and polynucleotides encoding OBP-NT polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing OBP-NT polypeptides to screen for antiviral compounds.
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公开(公告)号：EP1085872A1
公开(公告)日：2001-03-28
申请号：EP99930459.5
申请日：1999-06-18
IPC分类号： A61K31/535 , A61K31/495 , A61K31/445 , A61K31/40 , A61K31/135
CPC分类号： A61K31/135 , A61K31/4462 , A61K31/5375
摘要： The present invention provides amino-indanone inhibitors of transcription factor NF-λB and pharmaceutically acceptable salts, hydrates and solvates thereof, pharmaceutical compositions of such compounds, and methods for treating diseases in which activation of NF-λB is implicated. More specifically, the present invention provides methods of treatment of a variety of diseases associated with NF-λB activation including inflammatory disorders; particularly rheumatoid arthritis, inflammatory bowel disease, and asthma; dermatosis, including psoriasis and acute dermatosis; autoimmune diseases; tissue and organ rejection; Alzheimer's disease; stroke; atherosclerosis; restenosis; cancer, including Hodgkins disease; and certain viral infections, including AIDS; osteoarthritis; osteoporosis; and Ataxia Telangiestasia by administering to a patient in need thereof a compound of the present invention.
摘要翻译： 本发明提供转录因子NF-λB的氨基 - 茚酮抑制剂及其药学上可接受的盐，水合物和溶剂合物，这些化合物的药物组合物，以及治疗其中涉及NF-λB活化的疾病的方法。 更具体地说，本发明提供了治疗与NF-λB激活有关的多种疾病的方法，包括炎性疾病; 特别是类风湿性关节炎，炎症性肠病和哮喘; 皮肤病，包括牛皮癣和急性皮肤病; 自身免疫性疾病; 组织和器官排斥; 阿尔茨海默氏病; 行程; 动脉粥样硬化; 再狭窄; 癌症，包括霍奇金病; 和某些病毒感染，包括艾滋病; 骨关节炎; 骨质疏松症; 和共济失调毛细血管扩张症的方法，其通过向有需要的患者施用本发明的化合物来实现。
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公开(公告)号：EP1085848A2
公开(公告)日：2001-03-28
申请号：EP99930345.6
申请日：1999-06-18
IPC分类号： A61K6/00
CPC分类号： A61K31/165 , C07C235/64
摘要： The present invention provides pharmaceutical compositions of salicylanilide inhibitors of transcription factor NF-λB, and methods for treating diseases in which activation of NF-λB is implicated. More specifically, the present invention provides methods of treatment of a variety of diseases associated with NF-λB activation including inflammatory disorders; particularly rheumatoid arthritis, inflammatory bowel disease, and asthma; dermatosis, including psoriasis and atopic dermatitis; autoimmune diseases; tissue and organ rejection; Alzheimer's disease; stroke; atherosclerosis; restenosis; cancer, including Hodgkin's disease; certain viral infections, including AIDS; osteoarthritis; osteoporosis; and Ataxia Telangiestasia by administering to a patient in need thereof a compound of the present invention.
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公开(公告)号：EP1080087A1
公开(公告)日：2001-03-07
申请号：EP99925727.2
申请日：1999-05-20
IPC分类号： C07D401/04 , C07D403/04 , A61K31/44 , A61K31/505
CPC分类号： C07D401/04 , C07D403/04
摘要： The present invention is related to novel 2-alkyl substituted imidazole compounds of Formula (I) useful for the treatment of CSBP kinase mediated diseases.
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