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公开(公告)号：EP1242081A1
公开(公告)日：2002-09-25
申请号：EP00965555.6
申请日：2000-09-29
IPC分类号： A61K31/445 , A61K31/44 , A61K31/40
CPC分类号： A61K31/403
摘要： The present invention is to the novel compounds of Formula (I), their pharmaceutical compositions, and to the novel inhibition of caspases for use in the treatment of apoptosis, and disease states caused by excessive or inappropriate cell death.
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公开(公告)号：EP1129108A1
公开(公告)日：2001-09-05
申请号：EP99953073.6
申请日：1999-10-06
发明人： LEE, Dennis
IPC分类号： C07K5/08
CPC分类号： C07K5/0202 , A61K38/00
摘要： The present invention is related to the novel compounds of formula (I), their pharmaceutical compositions, and to the novel inhibition of caspases for use in the treatment of apoptosis, and disease states caused by excessive or inappropriate cell death.
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公开(公告)号：EP0799198B1
公开(公告)日：2000-08-30
申请号：EP95922184.7
申请日：1995-06-02
发明人： ADAMS, Jerry Leroy , HALL, Ralph Floyd , LEE, Dennis , MAYER, Ruth Judik , SEIBEL, George Leslie
IPC分类号： C07C311/21 , A61K31/195
CPC分类号： C07C311/29 , C07C311/13 , C07C311/17 , C07C311/21
摘要： This invention relates to the novel compounds and pharmaceutical compositions of formula (I). This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of formula (I).
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公开(公告)号：EP1756092A1
公开(公告)日：2007-02-28
申请号：EP05760213.8
申请日：2005-06-17
IPC分类号： C07D403/12 , A61K31/506 , A61P9/04 , A61P25/28
CPC分类号： C07D417/14 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14
摘要： Novel inhibitors of Rho-kinases are disclosed.
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公开(公告)号：EP1017664A1
公开(公告)日：2000-07-12
申请号：EP98950673.8
申请日：1998-09-23
发明人： LEE, Dennis
IPC分类号： C07C53/128 , A61K31/19
CPC分类号： C07C279/14 , C07C311/19
摘要： Novel C3A ligands are provided. Methods of using the present compunds to treat immune and inflammation disease are also provided.
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公开(公告)号：EP0859779A1
公开(公告)日：1998-08-26
申请号：EP96932941.0
申请日：1996-08-29
发明人： LEVY, Mark, Alan , LEE, Dennis , GLEASON, John, Gerald , TAYLOR, Andrew, William , CORBERTT, David, Francis
CPC分类号： C07D501/00
摘要： The present invention is to the novel compounds of Formula (I), their pharmaceutical compositions, and to the novel inhibition of ICE and ICE-like proteins for use in the treatment of apoptosis, and disease states caused by excessive or inappropriate cell death.
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公开(公告)号：EP0900083A1
公开(公告)日：1999-03-10
申请号：EP97902002.0
申请日：1997-01-10
IPC分类号： A61K31 , A61P1 , A61P3 , A61P7 , A61P9 , A61P11 , A61P17 , A61P19 , A61P25 , A61P29 , A61P31 , A61P43 , C07D401 , C07D403 , C07D405
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14
摘要： Novel 1,4,5-substituted imidazole compounds and compositions for use in therapy as cytokine inhibitors.
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公开(公告)号：EP0799198A1
公开(公告)日：1997-10-08
申请号：EP95922184.0
申请日：1995-06-02
发明人： ADAMS, Jerry Leroy , HALL, Ralph Floyd , LEE, Dennis , MAYER, Ruth Judik , SEIBEL, George Leslie
IPC分类号： A61K31 , A61P1 , A61P9 , A61P11 , A61P17 , A61P27 , A61P29 , A61P35 , A61P43 , C07C311 , C07C323
CPC分类号： C07C311/29 , C07C311/13 , C07C311/17 , C07C311/21
摘要： This invention relates to the novel compounds and pharmaceutical compositions of formula (I). This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of formula (I).
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公开(公告)号：EP1718638A1
公开(公告)日：2006-11-08
申请号：EP05723356.1
申请日：2005-02-18
发明人： LEE, Dennis , GOODMAN, Krista, B.
IPC分类号： C07D401/12
CPC分类号： C07D401/12 , C07D401/14 , C07D409/14
摘要： Novel inhibitors of Rho-kinases are disclosed.
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公开(公告)号：EP0900083B1
公开(公告)日：2003-08-20
申请号：EP97902002.1
申请日：1997-01-10
IPC分类号： A61K31/505 , C07D403/14
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14
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