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31 条记录 (耗时 0.025 秒)

    PHOTOLYTICALLY CLEAVABLE ENCODING AND LINKING AGENTS FOR USE IN COMBINATORIAL CHEMISTRY
    4.
    发明公开
    PHOTOLYTICALLY CLEAVABLE ENCODING AND LINKING AGENTS FOR USE IN COMBINATORIAL CHEMISTRY 失效
    光解FISSILE编码和结合剂FOR USE IN组合化学

    公开(公告)号：EP0817771A1

    公开(公告)日：1998-01-14

    申请号：EP96911512.0

    申请日：1996-03-29

    申请人： SMITHKLINE BEECHAM CORPORATION

    发明人： GARIGIPATI, Ravi, Shanker ,  ADAMS, Jerry, Leroy

    IPC分类号： C07D317 ,  C07C311 ,  C40B70

    CPC分类号： C07C311/16 ,  B01J2219/00572 ,  C40B70/00

    摘要： The present invention is to novel photochemically cleavable aryl sulfonamides of the formula: P-A3-A2-A1-S(O)2NR1R2 wherein: R1 and R2 are independently selected from optionally substituted alkyl, arylalkyl or heteroarylalkyl; A1 is an aryl or heteroaryl moiety; A2 is a linking agent is an aryl, heteroaryl, arylalkyl, heteroaryl alkyl, or an alkyl, wherein the alkyl moiety in the arylalkyl, heteroaryl alkyl, or alkyl group is optionally interrupted one or more times independently by oxygen, NR3, sulfur or an amide group; R3 is alkyl; A3 is an electron rich aryl or heteroaryl moiety having an E1/2 potential of 0.5 to 2.0 and which moiety is capable of forming an exciplex; P is a solid support. Another aspect of the present invention is to the novel use of these photolytically cleavable aryl sulfonamides in combinatorial chemistry synthesis, for use in non-sequential encoding, as a tagging agent. Another aspect of the present inevention is to the novel use of these photolytically cleavable aryl sulfonamides in combinatorial chemistry synthesis, as a linking agent which is bound to a solid support, and upon photolytic cleavage will provide a free amine of the desired final products, i.e. the use of sulfonamides for the solid phase synthesis of amines.

    CHEMICAL COMPOUNDS
    6.
    发明公开
    CHEMICAL COMPOUNDS 有权
    化学化合物

    公开(公告)号：EP1436279A1

    公开(公告)日：2004-07-14

    申请号：EP02761740.6

    申请日：2002-09-20

    申请人： SmithKline Beecham Corporation

    发明人： ADAMS, Jerry, Leroy ,  SILVA, Domingos

    IPC分类号： C07D333/36 ,  A61K31/38

    CPC分类号： A61K31/381 ,  C07D333/38

    摘要： Thiophene derivatives are described herein. The described invention also includes methods of making such thiophene derivatives as well as methods of using the same in the treatment of diseases.

    摘要翻译： 本文描述噻吩衍生物。 所描述的发明还包括制备这种噻吩衍生物的方法以及在治疗疾病中使用它们的方法。