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282 条记录 (耗时 0.019 秒)

    INFLAMMATION-RELATED GENE
    92.
    发明公开
    INFLAMMATION-RELATED GENE 审中-公开
    点火相关基因

    公开(公告)号：EP1261640A2

    公开(公告)日：2002-12-04

    申请号：EP01925373.1

    申请日：2001-03-05

    申请人： Novartis AG

    发明人： JARAI, Gabor ,  COOPER, Paul, Roy ,  YOUSEFI, Shida

    IPC分类号： C07K14/705 ,  C12N15/12 ,  C12N15/11 ,  C12Q1/68 ,  A61K38/17 ,  A61P11/00 ,  A61P1/00 ,  A61P19/00

    CPC分类号： C07K14/705

    摘要： The use of (A) a polypeptide comprising the amino acid sequence of SEQ ID NO:2, or a functionally equivalent variant of that amino acid sequence, or (B) a polynucleotide comprising a nucleotide sequence encoding the polypeptide (A), or (C) an antibody which is immunoreactive with the polypeptide (A), or (D) an antisense oligonucleotide comprising a nucleotide sequence complementary to that of polynucleotide (B), or (E) a polynucleotide probe comprising at least 15 consecutive nucleotides of (B), in the preparation of a pharmaceutical for the diagnosis or treatment of a neutrophil-associated inflammatory disease.

    COMBINATION OF N-PHENYL-N'-BENZOYL UREA DERIVATIVE AND NECTIN COMPOUNDS FOR PARASITE CONTROL
    96.
    发明公开
    COMBINATION OF N-PHENYL-N'-BENZOYL UREA DERIVATIVE AND NECTIN COMPOUNDS FOR PARASITE CONTROL 有权
    合并及伊维菌素啶蜱脲组成抗寄生虫

    公开(公告)号：EP1244359A1

    公开(公告)日：2002-10-02

    申请号：EP00985086.8

    申请日：2000-11-23

    申请人： Novartis AG ,  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.

    发明人： BOUVIER, Jacques ,  KOLLY, Catherine

    IPC分类号： A01N43/90

    CPC分类号： A01N47/34 ,  A01N43/90 ,  A01N2300/00

    摘要： An active ingredient combination for the simultaneous control of ecto- and endoparasites, especially mites, ticks and nematodes, on productive livestock, domestic animals and pets, is described, which comprises the active ingredients (1) 1-[4-chloro-3-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl]-3-(2,6-difluorobenzoyl)urea and (2) a compound of formula (i) wherein R1 is hydrogen or one of radicals (ii) or (iii), R2 is CH(CH3)-CH3, -CH(CH3)-C2H5, -C(CH3)=CH-CH(CH3)2 or cyclohexyl; R3 is hydrogen or hydroxy if the bond between atoms 22 and 23 represents a double bond, or is hydrogen or the group =N-O-CH3 if a single bond is present between atoms 22 and 23; and R4 is HO- or HO-N=, in free form or in the form of a physiologically acceptable salt.

    CONTACT LENS
    98.
    发明公开
    CONTACT LENS 有权
    隐形眼镜

    公开(公告)号：EP1236068A1

    公开(公告)日：2002-09-04

    申请号：EP00982514.2

    申请日：2000-12-07

    申请人： Wesley Jessen Corporation

    发明人： ROSENZWEIG, Howard, S. ,  QUINN, Michael, H. ,  TUCKER, Robert ,  CARLSON, Greg ,  OCAMPO, Gerardo, J.

    IPC分类号： G02C7/04 ,  B29D11/00 ,  C08F30/08

    CPC分类号： G02B1/043 ,  C08F220/56 ,  C08F230/08 ,  Y10S525/937 ,  C08L43/04 ,  C08L83/04

    摘要： This invention is directed to ophthalmic materials and ophthalmic lenses that are a co-polymerization product of a (a) hydrophilic monomer with (b) a tris(siloxy)silyl group-containing monomer, (c) a wide variety of hydrophobic monomers (both aliphatic and aromatic) and usually a (d) polyfluorinated monomer, as well as optional monomers or monomer mixtures that can include a cationic monomer, a non-aromatic hydrophobic monomer and a poly(dimethylsiloxy)silyl group-containing monomer. A contact lens prepared from such a co-polymer exhibits enhanced water content, while maintaining exceptional oxygen permeability, thereby providing a lens that can be worn comfortably for prolonged periods of time. A process for the preparation of such lenses is also disclosed.

    摘要翻译： 本发明涉及作为（a）亲水单体与（b）含三（甲硅烷氧基）甲硅烷基的单体的共聚产物的眼科材料和眼镜片，（c）多种疏水单体 （d）多氟化单体，以及任选单体或单体混合物，其可以包括阳离子单体，非芳族疏水单体和含聚（二甲基甲硅烷氧基）甲硅烷基的单体。 由这种共聚物制备的隐形眼镜表现出增强的含水量，同时保持优异的透氧性，从而提供可以长时间舒适地佩戴的镜片。 还公开了制备这种镜片的方法。

    VALNEMULIN FORMULATION
    99.
    发明公开
    VALNEMULIN FORMULATION 有权
    INIERZIERBARE沃尼妙林配方

    公开(公告)号：EP1235566A2

    公开(公告)日：2002-09-04

    申请号：EP00990671.0

    申请日：2000-12-07

    申请人： Novartis AG ,  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.

    发明人： KOLLER, Kurt ,  SCHWARZ, Franz

    IPC分类号： A61K31/22 ,  A61K47/12 ,  A61K47/10

    CPC分类号： A61K9/0019 ,  A61K31/221 ,  A61K47/10 ,  A61K47/12

    摘要： The preparation of an improved galenic delivery form of valnemulin, which is notable for its good tolerance and stability in storage, is described. The new delivery form in question is a non-aqueous or oily injection formulation, which is obtainable by means of in situ preparation and subsequent stabilisation of the free, relatively unstable base of the active ingredient. A further aspect of the present invention concerns the usage of such an injection formulation in a method of treating infectious diseases in productive livestock or domestic animals.