公开(公告)号：EP3336192A1

公开(公告)日：2018-06-20

申请号：EP18153133.6

申请日：2014-11-12

申请人： Vrije Universiteit Brussel

发明人： HEIRMAN, Carlo ,  THIELEMANS, Kristiaan

IPC分类号： C12N15/85 ,  A61K39/00 ,  A61K31/7088

CPC分类号： A61K48/0066 ,  A61K31/7105 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55516 ,  C07K14/70575 ,  C07K14/70596 ,  C12N15/85 ,  C12N2320/52 ,  C12N2830/50 ,  C12N2840/105

摘要： The present invention in general relates to an improved RNA transcription vector, which is very suitable for the production of mRNA for in vivo therapeutic purposes. The improvements in the vector in particular reside in the presence of a transcription enhancer and a nuclear retention element.

公开(公告)号：EP3300209A1

公开(公告)日：2018-03-28

申请号：EP16190644.1

申请日：2016-09-26

申请人： Laborelec CVBA

发明人： BOUCHAIR, Nabil ,  JAHN, Rafaël ,  CRUNELLE, Cathy ,  MOENCH, Pierre

IPC分类号： H02J3/38 ,  F24H9/20 ,  F24D19/10 ,  H05B1/02 ,  G05D23/19

CPC分类号： H02J3/383 ,  F24D19/1057 ,  F24H9/2021 ,  G05D23/1917 ,  H05B1/0283 ,  Y02E10/563

摘要： An energy efficient energy generation and consumption system (20) comprising an energy supply installation (400); a power supply control device (420) adapted to determine whether it is efficient to supply the generated energy either to the grid (410) or for direct use otherwise by an energy consuming device, preferably with an energy storage capability; and an energy efficient electrical heating arrangement (10), wherein said second electronic control device (130) being part of said power supply control device (420), and said means (100) for providing electrical power being connected to said energy supply installation (400) or to the grid (410) via said power supply control device (420).

摘要翻译： 一种高能效能源生产和消费系统（20），包括一个能量供应设备（400）; 电源控制装置（420），其适于确定是否有效地将所产生的能量提供给电网（410），或者用于直接使用否则由能量消耗装置，优选地具有能量存储能力; 和能量有效的电加热装置（10），其中所述第二电子控制装置（130）是所述电源控制装置（420）的一部分，并且所述用于提供电力的装置（100）连接到所述能量供应装置 400）或经由所述电力供应控制装置（420）到达电网（410）。

公开(公告)号：EP3139742B1

公开(公告)日：2018-03-28

申请号：EP15724063.1

申请日：2015-05-05

申请人： Globachem NV

发明人： DENRUYTER, Lieven ,  QUAGHEBEUR, Koen

IPC分类号： A01N43/60 ,  A01P17/00 ,  A01N37/44 ,  A01N65/42 ,  A01N65/28

CPC分类号： A01N43/60 ,  A01N37/44 ,  A01N65/00 ,  A01N65/28 ,  A01N65/42

摘要： The present invention relates to a method for repelling pests in a crop, in which a composition comprising 2-isopropyl-3-methoxypyrazine (IPMP) is prepared and applied above the ground as a pest repellent, particularly a pest repellent against vertebrates that feed on parts of vegetative plants above the ground. The present invention is also intended to be a method of repelling pests in a crop, wherein a composition containing IPMP and at least one additional pest-repelling substance is prepared, and wherein this composition is applied above the ground. This involves in particular the forms of application and the synergistic combinations of IPMP with a repellent selected from the group comprising denatonium benzoate, onion extract or other plant extracts (for example eucalyptus extract), or with the combination of Bitrex with onion extract or other plant extracts (for example eucalyptus extract).

公开(公告)号：EP3287165A1

公开(公告)日：2018-02-28

申请号：EP16185984.8

申请日：2016-08-26

申请人： Medec Benelux NV

发明人： Braem, Kristof

IPC分类号： A61M16/00

CPC分类号： A61M16/00 ,  A61M2230/40

摘要： The present invention is related to the field of anesthesia and perioperative mechanical ventilation of patients. It provides an improved protocol of perioperative mechanical ventilation of patients as well as a mechanical ventilation device performing said procedure.
The protocol of the instant application is a volume-controlled, time-cycled ventilation mode wherein a variable TV is applied at a constant respiration rate with a variable inspiratory time (I) and thus a variable I:E ratio, but wherein the variability in TV is such that the total volume delivered over time is kept constant, and wherein the variability in I is such that the peak level of inspiratory flow is kept at a constant level.

摘要翻译： 本发明涉及麻醉和围手术期机械通气领域。 它提供了改进的患者围术期机械通气协议以及执行所述程序的机械通气装置。 本申请的方案是体积受控的时间循环的通气模式，其中以恒定的呼吸率以可变的吸气时间（I）并因此可变的I:E比率施加可变TV，但是其中可变的TV TV使得随时间传递的总体积保持恒定，并且其中I的变化性使得吸气流量的峰值水平保持在恒定水平。

公开(公告)号：EP2723287B1

公开(公告)日：2018-02-07

申请号：EP12755901.1

申请日：2012-06-26

申请人： De Man Projects SA

发明人： DE MAN, Cédric Lodewijk H

IPC分类号： A61F13/06 ,  A61F13/10 ,  A61F13/00

CPC分类号： A61F13/00038 ,  A61F13/00029 ,  A61F13/00987 ,  A61F13/068 ,  A61F13/105 ,  A61F2013/00093 ,  A61F2013/00119 ,  A61F2013/00217 ,  A61F2013/0048 ,  Y10T156/10

摘要： Tubular bandage, in particular a finger or toe bandage which is formed as a tube comprising an outer layer which is connected to an inner layer, and wherein the outer layer has a diameter and an elasticity such that the bandage can be clamped adhesive-free around the body part to be treated, in the particular, said finger or said toe, and wherein the inner layer is made of an elastic wound-protective material, wherein said outer layer is made of an air-permeable and water-repellent material, and wherein, at the open endings, said outer layer extends in the longitudinal direction over the inner layer over a distance of more than 0.5 mm, such that the outer layer touches the body part to be treated, in particular a finger or toe, with its endings when applied.

公开(公告)号：EP3263223A1

公开(公告)日：2018-01-03

申请号：EP17178360.8

申请日：2017-06-28

申请人： Bandit NV

发明人： Vandonninck, Alfons

IPC分类号： B05B1/00 ,  B05B7/08 ,  B05B7/16 ,  F41H9/06 ,  G08B15/02 ,  B05B1/18

CPC分类号： B05B7/1686 ,  B05B1/18 ,  B05B7/08 ,  B05B7/0892 ,  F41H9/06

摘要： The invention relates to a nozzle for distributing a heat-vaporsed fog liquid. The nozzle includes multiple outlets, which are designed so that the flow rate from the outlets in the central part is lower than the flow rate from those in the peripheral part.

摘要翻译： 本发明涉及用于分配热蒸汽雾化液体的喷嘴。 喷嘴包括多个出口，其被设计为使得来自中心部分的出口的流速低于来自周边部分的流速。

公开(公告)号：EP3256141A1

公开(公告)日：2017-12-20

申请号：EP16703546.8

申请日：2016-02-09

申请人： Vereeken, Jose

发明人： Vereeken, Jose

IPC分类号： A61K36/515 ,  A61K36/9068 ,  A61K36/28 ,  A61K9/14 ,  A61K9/16 ,  A61K47/02

CPC分类号： A61K36/515 ,  A61K9/1652 ,  A61K36/28 ,  A61K36/9068

摘要： The present invention relates to multiparticulate formulations comprising herbal extracts, in particular spray-dried herbal extracts, said multiparticulate formulations being prepared by extrusion-spheronization. In particular, said multiparticulate formulations comprise colloidal silicon dioxide at a total concentration of about 1 % w/w to about 5% w/w. Furthermore, the present invention relates to the use of such formulations in human or veterinary medicine as well as methods for preparing such formulations.

公开(公告)号：EP2457128B1

公开(公告)日：2017-09-06

申请号：EP10742335.2

申请日：2010-07-23

申请人： Day International, Inc.

发明人： JENNINGS, Jeffrey, D. ,  SHANNON, Allen ,  CZERNER, Richard

IPC分类号： G03G15/16

CPC分类号： G03G15/1685 ,  G03G15/162 ,  Y10T428/24273 ,  Y10T428/249955 ,  Y10T428/249979 ,  Y10T428/249991 ,  Y10T428/249992

公开(公告)号：EP2700708B1

公开(公告)日：2017-08-02

申请号：EP13181345.3

申请日：2013-08-22

申请人： VRIJE UNIVERSITEIT BRUSSEL

发明人： Thielemans, Kris, Maria, Magdalena ,  Bonehill, Aude

IPC分类号： C12N5/0784

CPC分类号： A61K39/39 ,  A61K39/0011 ,  A61K2039/5154 ,  A61K2039/5156 ,  A61K2039/5158 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/55516 ,  A61K2039/57 ,  C12N5/0639 ,  C12N2510/00 ,  Y02A50/386 ,  Y02A50/403 ,  Y02A50/407 ,  Y02A50/484

摘要： With the current invention, we provide new methods of enhancing the T-cell stimulatory capacity of human dendritic cells (DCs) and their use in cancer vaccination. The method comprises the introduction of different molecular adjuvants to human DCs through transfection with at least two mRNA or DNA molecules encoding markers selected from the group of: CD40L, CD70, constitutively active TLR4 (caTLR4), IL-12p70, EL-selectin, CCR7 and/or 4-1 BBL; or in combination with inhibition of SOCS, A20, PD-L1 and/or STAT3 expression, for example through siRNA transfection. We could show a clear increase in the immunostimulatory capacity of DCs obtained in this way, enabling them to elicit an unexpectedly high T-cell immune response in vitro. Introduction of at least two of the above molecules, in combination with a tumor-specific antigen enables the DCs to elicit a significant host-mediated T-cell immune response in vivo against the tumor antigen and thus makes them very attractive in the manufacturing of anti-cancer vaccines.

公开(公告)号：EP3194407A1

公开(公告)日：2017-07-26

申请号：EP15766800.5

申请日：2015-09-17

申请人： Oncodesign S.A.

发明人： HOFLACK, Jan ,  BLOM, Petra ,  BENDERITTER, Pascal

IPC分类号： C07D498/22 ,  A61K31/529 ,  A61P29/00

CPC分类号： C07D498/22

摘要： The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of RIP2 and/or mutants thereof, for use in the diagnosis, prevention and/or treatment of RIP2-kinase associated diseases. Moreover, the present invention provides methods of using said compounds, for instance as a medicine or diagnostic agent.

摘要翻译： 本发明涉及大环化合物和含有用作激酶抑制剂的所述化合物的组合物，特别是用作RIP2和/或其突变体的抑制剂，用于诊断，预防和/或治疗RIP2-激酶相关疾病。 而且，本发明提供了使用所述化合物的方法，例如作为药物或诊断剂。