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    ELECTRODE STRUCTURE FOR IONTOPHORESIS DEVICES AND METHOD OF PRODUCING THE SAME
    91.
    发明公开
    ELECTRODE STRUCTURE FOR IONTOPHORESIS DEVICES AND METHOD OF PRODUCING THE SAME 审中-公开
    ELEKTRODENSTRUKTURFÜRIONTOPHORESEGERÄTEUND VERFAHREN ZU DEREN HERSTELLUNG

    公开(公告)号：EP1177814A1

    公开(公告)日：2002-02-06

    申请号：EP00925579.5

    申请日：2000-05-10

    申请人： HISAMITSU PHARMACEUTICAL CO. INC.

    发明人： KURIBAYASHI, M., T. Lab. Of Hisamitsu Pha. Co. Inc ,  MAEDA, H., Tsukuba Lab. of Hisamitsu Pha. Co. Inc. ,  KOGA, N., Tsukuba Lab. of Hisamitsu Phar. Co. Inc. ,  HIGO, N., Tsukuba Lab. of Hisamitsu Phar. Co. Inc.

    IPC分类号： A61N1/30

    CPC分类号： A61N1/044 ,  A61N1/0436 ,  A61N1/0448

    摘要： The invention is to provide an electrode structure of an iontophoresis device and a method of producing the same, excellent in an economical property, an operational property, stability and safety. The electrode structure for the iontophoresis device comprises a backing having a substrate film (1) having a molding portion, an anode side and a cathode side electrode layers (14), (15) formed passing the outer circumferential portion from the inner bottom of the molding portion, and an insulating layer 3 formed in the outer circumferential portion of the molding portion. The molding portion of the backing has a dent portion and an anode side and a cathode side conductive layers (12), (13) are separately installed therein. A cover member (8) is installed to seal between these conductive layers (12), (13) and the insulating layer (3). An adhesive sheet (10) for attachment to the skin is provided to the rear face of the substrate film (1) and a liner (16) for the adhesive sheet is provided on the cover member (8).

    摘要翻译： 本发明提供离子电渗装置的电极结构及其制造方法，经济性，操作性，稳定性，安全性优异。 用于离子电渗装置的电极结构包括：背衬，具有具有模制部分的基底膜（1），阳极侧和阴极侧电极层（14），（15），其形成为穿过外周部分 模制部分和形成在模制部分的外圆周部分中的绝缘层3。 背衬的模制部分具有凹部和阳极侧，并且阴极侧导电层（12），（13）分别安装在其中。 盖构件（8）被安装以密封在这些导电层（12），（13）和绝缘层（3）之间。 在基材膜（1）的背面设有用于附着于皮肤的粘合片（10），在盖部件（8）上设置粘接片用衬垫（16）。

    Iontophoresis system
    94.
    发明公开
    Iontophoresis system 审中-公开
    离子电渗疗法系统

    公开(公告)号：EP1084729A3

    公开(公告)日：2001-06-13

    申请号：EP00119489.3

    申请日：2000-09-18

    申请人： HISAMITSU PHARMACEUTICAL CO. INC.

    发明人： Inoue, Kazutaka, Tsukuba Laboratory of Hisamitsu

    IPC分类号： A61N1/30 ,  A61N1/32

    CPC分类号： A61N1/30

    摘要： An iontophoresis system comprises a power supply apparatus having a chargeable battery, a positive output terminal, a negative output terminal and a positive charge terminal, and a preparation having input terminals connected to output terminals of the power supply apparatus. The negative output terminal of the power supply apparatus also serves as a negative charge terminal for charging the battery. During charging, the preparation is removed, and terminals of a charger are connected to terminals of the power supply apparatus, respectively. The power supply apparatus comprises a power supply monitoring portion which gives a warning when a battery voltage becomes a predetermined value or lower and a control portion for controlling a power supply state from the output terminal.

    摘要翻译： 离子电渗疗法系统包括具有可充电电池，正输出端子，负输出端子和正充电端子的电源装置，以及具有连接到电源装置的输出端子的输入端子的制剂。 电源设备的负输出端子还充当用于对电池充电的负电荷端子。 在充电期间，准备被移除，并且充电器的端子分别连接到电源装置的端子。 该电源装置包括当电池电压变为预定值或更低时发出警报的电源监视部分和用于控制来自输出端子的电源状态的控制部分。

    SUBSTANCE HAVING STEROID-LIKE STRUCTURE, PROCESS FOR THE PRODUCTION THEREOF AND ANTITUMOR AGENTS CONTAINING THE SAME
    96.
    发明公开
    SUBSTANCE HAVING STEROID-LIKE STRUCTURE, PROCESS FOR THE PRODUCTION THEREOF AND ANTITUMOR AGENTS CONTAINING THE SAME 审中-公开
    类固醇样结构，及其制备方法抗肿瘤物质手段，这包括

    公开(公告)号：EP1057832A1

    公开(公告)日：2000-12-06

    申请号：EP99905313.5

    申请日：1999-02-25

    申请人： HISAMITSU PHARMACEUTICAL CO., INC.

    发明人： PAN, Tair-Long ,  GOTO, Sigeru ,  CHEN, Chao-Long

    IPC分类号： C07J9/00 ,  A61K35/84

    CPC分类号： A61K36/068

    摘要： This invention provides a separation method by which a compound having an antitumor effect possessed by Tochukaso can be obtained in a pure state. Further, this invention reveals the chemical structure of the compound having such antitumor effect. Still further, the invention aims at providing an antitumor agent comprising said compound.

    摘要翻译： 本发明提供一种分离方法，通过该具有由冬虫夏草所具有的抗肿瘤效果的化合物可以以纯态得到。 此外，本发明揭示经审查的化合物的化学结构的抗肿瘤效果。 更进一步地，本发明的目的在于提供，以抗肿瘤剂包含所述化合物。

    PLASTER STRUCTURE FOR IONTOPHORESIS
    99.
    发明公开
    PLASTER STRUCTURE FOR IONTOPHORESIS 失效
    IOPOPHORESE PFLASTER

    公开(公告)号：EP0846473A1

    公开(公告)日：1998-06-10

    申请号：EP95928026.4

    申请日：1995-08-14

    申请人： HISAMITSU PHARMACEUTICAL CO. INC.

    发明人： HIGO, Naruhito ,  MORI, Kenji ,  NAKAMURA, Katsuhiro

    IPC分类号： A61N1/30

    CPC分类号： A61N1/0448 ,  A61N1/0428 ,  A61N1/303

    摘要： It is an object of this invention to provide a plaster structure for iontophoresis in which a predetermined amount of physiologically active agents initially set can be stably kept or held without any loss until it is applied to a patient, and when the agents are applied to the patient, the predetermined amount of physiologically active agents initially set can be applied stably and continuously to an entire body of the patient and concurrently a mutual action between the physiologically active agents or additive agents and the adhesive agent is prevented, an adhering power of the adhesive agent is kept and it may not be peeled off during its application.
    The plaster structure for iontophoresis is comprised of an electrical conductive medicinal substance storing layer 1 containing the physiologically active agents, a backing layer 2 covering the medicinal substance storing layer 1 and having an electrode 3 installed therein, a protection layer 4 supporting the medicinal substance storing layer 1 and which is non-permeable against the physiologically active agents, an adhesive agent layer 5 comprised of pressure-sensitive adhesive agent with a superior skin adhering characteristic and/or mucous membrane adhering characteristic laminated on the other surface of the protection layer 4, a liner layer 6 laminated on the other surface of the adhesive agent layer 5, and a notch part 7 formed in the protection layer 4.

    摘要翻译： 本发明的目的是提供一种用于离子电渗疗法的膏药结构，其中初始设定的预定量的生理活性剂可以稳定地保持或保持，直到其施用于患者，并且当将药剂施用于 患者，可以将初始设定的预定量的生理活性剂稳定且持续地施用于患者的整个身体，同时可以防止生理活性剂或添加剂与粘合剂之间的相互作用，粘合剂的粘附力 代理商被保留，并且在应用期间可能不会剥离。 用于离子电渗的石膏结构由含有生理活性剂的导电药物储存层1，覆盖药物储存层1的背衬层2和安装有电极3的保护层4构成，保护层4支撑药物储存 层1，其对于生理活性剂是不可渗透的，由保护层4的另一表面层压的具有优异的表皮粘附特性和/或粘膜粘附特性​​的压敏粘合剂组成的粘合剂层5， 层叠在粘合剂层5的另一个表面上的衬里层6和形成在保护层4中的凹口部7.图像

    Non-crosslinked anion exchange resin and pharmaceutical composition containing same
    100.
    发明公开
    Non-crosslinked anion exchange resin and pharmaceutical composition containing same 失效
    非交联阴离子交换树脂及含有其的药物组合物

    公开(公告)号：EP0835888A3

    公开(公告)日：1998-05-27

    申请号：EP97119915.3

    申请日：1993-01-11

    申请人： HISAMITSU PHARMACEUTICAL CO. INC.

    发明人： Okayama, Minenobu, c/o Hisamitsu Pharm. Co., Ltd. ,  Sato, Shuji, c/o Hisamitsu Pharm. Co., Ltd.

    IPC分类号： C08F20/34 ,  A61K31/785

    CPC分类号： C08F20/34 ,  A61K31/785

    摘要： A non-crosslinked anion exchange resin consisting of structural units represented by the general formula (I):
    wherein R 1 represents a benzyl group or an alkyl group having 1 to 20 carbon atoms, R 2 and R 3 may be identical or different and each represent a lower alkyl group having 1 to 4 carbon atoms, R 4 represents a hydrogen atom or a lower alkyl group, X represents a physiologically acceptable counter ion, n is an integer of from 1 to 3, and p is an average degree of polymerization ranging from 10 to 10,000;
    and a pharmaceutical composition comprising said non-crosslinked anion exchange resin.

    摘要翻译： 由通式（I）表示的结构单元组成的非交联阴离子交换树脂：其中R1表示苄基或具有1至20个碳原子的烷基，R2和R3可以相同或不同，并且各自表示低级 具有1至4个碳原子的烷基，R 4表示氢原子或低级烷基，X表示生理上可接受的抗衡离子，n是1至3的整数，并且p是平均聚合度范围为10至 10,000; 和包含所述非交联阴离子交换树脂的药物组合物。