公开(公告)号：EP4249608A2

公开(公告)日：2023-09-27

申请号：EP23191313.8

申请日：2015-08-28

申请人： Cedars-Sinai Medical Center ,  The Regents of the University of California ,  United States Government Represented by the Department of Veterans Affairs

发明人： TAJBAKHSH, Jian ,  MORTAZAVI, Fariborz

IPC分类号： C12Q1/6886

摘要： In certain embodiments, this application discloses methods for detecting lung cancer. The method includes characterization of cells extracted from human sputum, which is a valuable tissue surrogate and source of upper respiratory cells that become cancerous early in the process of lung cancer development. The method includes the staining of extracted cells with fluorescent reporters that produce a specific pattern in the nuclei of labeled cells, which can be made visible by light microscopy. The pattern is relevant to a type of epigenetic coding of DNA known as DNA methylation, which changes in specific cells of the lung during cancer development, in comparison to normal respiratory cells.

公开(公告)号：EP4247946A2

公开(公告)日：2023-09-27

申请号：EP22737300.8

申请日：2022-01-11

申请人： The Regents of The University of California

发明人： MALI, Prashant ,  PORTELL, Andrew ,  DAILAMY, Amir ,  KUMAR, Aditya

IPC分类号： C12N15/09 ,  C12N15/11 ,  C12N15/113 ,  C12Q1/68

公开(公告)号：EP4247940A1

公开(公告)日：2023-09-27

申请号：EP21895414.7

申请日：2021-11-15

申请人： The Regents of the University of California

发明人： LANIER, Lewis L. ,  WELLS, James A. ,  LIU, Jia ,  ARAKAWA-HOYT, Janice

IPC分类号： C12N5/0783 ,  A61K39/395 ,  C07K16/28 ,  A61K35/17

公开(公告)号：EP4245370A2

公开(公告)日：2023-09-20

申请号：EP23188169.9

申请日：2011-07-12

申请人： University of Southern California ,  California Institute of Technology ,  The Regents of University of California

发明人： CLEGG, Dennis ,  JOHNSON, Lincoln Vallance ,  GRUBBS, Robert ,  AHUJA, Ashish ,  HUMAYUN, Mark ,  TAI, Yu-Chong ,  HIKITA, Sherry T ,  HINTON, David

IPC分类号： A61P27/00

摘要： A substrate for cellular therapy to treat diseased or damaged ocular tissue wherein the substrate comprises:
a) a basal surface that comprises a single continuous support that comprises a plurality of pores or cylindrical recesses and wherein the plurality of pores of cylindrical recesses are in a periodic pattern in the single continuous support
and
b) a substantially homogeneous apical surface produced by deposition of parylene over the basal single continuous support,

wherein the apical surface provides a surface for cellular growth, and
wherein the apical surface is configured to facilitate the growth of a monolayer of cells and the basal single continuous support is configured to inhibit cell growth.

公开(公告)号：EP4245217A2

公开(公告)日：2023-09-20

申请号：EP23190692.6

申请日：2017-11-10

申请人： The Regents of The University of California

发明人： The designation of the inventor has not yet been filed

IPC分类号： A61B5/083

摘要： Resuscitation and ventilation monitoring devices are provided. A device includes an inlet in fluid communication with airflows exchanged with lungs of a patient and an airflow meter for measuring characteristics of the airflows. A user may provide a controller with patient information, e.g., height, weight, gender, or age, via a measurement selector, enabling the controller to determine acceptable ranges of measured airflow characteristics. The device may determine a current mode of ventilation and associated ventilator settings based on the measured airflow characteristics. The device may also identify and filter out artifacts present in the ventilation signal, and determine whether a respiratory failure phenotype is present in the ventilation. If the current mode of ventilation and associated ventilator settings fall outside an acceptable range, the ventilation is classified as off-target and the controller may cause a sensory alarm to alert the user. The device may suggest a corrective action based on the type of off-target ventilation detected. The device may also continuously analyze ventilation to determine changes in lung compliance over time and to identify pathological changes over time. The device may work within a network of devices and user interfaces via wired or wireless communication, and is not restricted to or dependent on the type of ventilatory device with which a patient is being supported.

公开(公告)号：EP4243853A2

公开(公告)日：2023-09-20

申请号：EP21892740.8

申请日：2021-11-10

申请人： The Regents of the University of California

发明人： SHAH, Ishita M. ,  GERMAN, J., Bruce ,  MILLS, David, A. ,  LEBRILLA, Carlito, B.

IPC分类号： A61K38/17 ,  C07K14/47 ,  A61P31/04

公开(公告)号：EP4241199A1

公开(公告)日：2023-09-13

申请号：EP21890357.3

申请日：2021-11-09

申请人： The Regents of the University of California

发明人： KABACHNIK, Lorna

IPC分类号： G06K9/00 ,  G10C3/08

公开(公告)号：EP4240338A1

公开(公告)日：2023-09-13

申请号：EP22734850.5

申请日：2022-01-04

申请人： The Regents of The University of California

发明人： MALI, Prashant ,  KATREKAR, Dhruva ,  YEN, James

IPC分类号： A61K31/105 ,  C12N15/11 ,  C12N15/113 ,  C12N15/12 ,  C12N15/85 ,  C12Q1/68

公开(公告)号：EP4237554A1

公开(公告)日：2023-09-06

申请号：EP21816227.9

申请日：2021-10-29

申请人： University of Washington ,  The Regents of the University of California

发明人： PULTZ, Ingrid, Swanson ,  WOLF, Clancey ,  SIEGEL, Justin, Bloomfield ,  TINBERG, Christine, Elaine ,  STEWART, Lance ,  BAKER, David

IPC分类号： C12N9/50 ,  A61K38/00 ,  A61P1/14 ,  C12N9/52

公开(公告)号：EP4236771A1

公开(公告)日：2023-09-06

申请号：EP21887375.0

申请日：2021-10-26

申请人： The Regents of University of California

发明人： KHADEMHOSSEINI, Alireza ,  ZHANG, Shiming

IPC分类号： A61B5/00 ,  A61B18/14 ,  C09K11/06 ,  G01N27/327