公开(公告)号：EP1301179A2

公开(公告)日：2003-04-16

申请号：EP01951670.7

申请日：2001-07-12

申请人： HEXAL AG

发明人： KLOKKERS, Karin ,  KRAMER, Kai-Thomas ,  WILHELM, Martina

IPC分类号： A61K9/70 ,  A61K47/02

CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K47/02

摘要： The invention relates to a transdermal therapeutic system comprising a surface layer which is impervious with respect to an active ingredient; a self-adherent matrix layer or a plurality of matrix layers, wherein the exposed matrix layer is, at least self-adherent when the system is applied. Said system also comprises a pull-off protective coating, whereby the matrix layer(s) contains(s) one or more active ingredients and/or one or more biologically active substances and highly dispersed silicon dioxide. Said system contains silicon dioxide in order to increase skin permeation.

公开(公告)号：EP1194134A1

公开(公告)日：2002-04-10

申请号：EP00951373.0

申请日：2000-07-12

申请人： HEXAL AG

发明人： STRÜNGMANN, Thomas,Hexal AG

IPC分类号： A61K9/70 ,  A61K31/135

CPC分类号： A61K9/7061 ,  A61K9/7084 ,  A61K31/135

摘要： The invention relates to an active substance containing transdermal system for the utilization of tolterodine, 5-hydroxymethyl tolterodine, to their pharmaceutically acceptable salts or a mixture thereof.

公开(公告)号：EP0835100B1

公开(公告)日：2002-01-02

申请号：EP96919764.9

申请日：1996-05-10

申请人： HEXAL AG

发明人： FISCHER, Wilfried ,  BRACHER, Daniel

IPC分类号： A61K9/127 ,  A61K31/52

CPC分类号： A61K31/522 ,  A61K9/127

摘要： The invention concerns an aqueous pharmaceutical preparation intended for topical application and containing aciclovir or an aciclovir derivative.

公开(公告)号：EP0825865B1

公开(公告)日：2001-11-07

申请号：EP96919765.6

申请日：1996-05-10

申请人： HEXAL AG

发明人： FISCHER, Wilfried ,  BRACHER, Daniel

IPC分类号： A61K31/565 ,  A61K9/70

CPC分类号： A61K31/568 ,  A61K9/703 ,  A61K9/7084 ,  A61K47/6951 ,  B82Y5/00

摘要： The invention concerns a transdermal therapeutic system for administering testosterone or a testosterone derivative as the active substance.

公开(公告)号：EP1140057A1

公开(公告)日：2001-10-10

申请号：EP99963581.6

申请日：1999-12-16

申请人： HEXAL AG

发明人： STRÜNGMANN, Thomas

IPC分类号： A61K31/155 ,  A61K31/64 ,  A61K31/80 ,  A61K31/13 ,  A61P3/10

CPC分类号： A61K31/702 ,  A61K9/209 ,  A61K31/155 ,  A61K31/64 ,  A61K31/80 ,  A61K31/70 ,  A61K2300/00

摘要： The invention relates to a pharmaceutical composition with improved effect and tolerability for the treatment of type II diabetes mellitus. Said composition contains a combination of metformin and/or its pharmaceutically acceptable salts and glimepiride and/or acarbose and optionally poly-(dimethyl)-siloxane as active components.

公开(公告)号：EP0748218B1

公开(公告)日：2001-08-01

申请号：EP95909746.0

申请日：1995-02-20

申请人： HEXAL AG

发明人： FISCHER, Wilfried, Dr. ,  KLOKKERS, Karin, Dr.

IPC分类号： A61K31/135 ,  A61K9/70

CPC分类号： A61K9/7084 ,  A61K31/135

摘要： A plaster-shaped transdermal system contains a tamoxifen derivative as well as a resorption-promoting additive for systemic application.

公开(公告)号：EP1097090A1

公开(公告)日：2001-05-09

申请号：EP99934662.0

申请日：1999-07-12

申请人： HEXAL AG

发明人： KIBELE, Ralf ,  KLOKKERS, Karin ,  SCHLUETER, Hans-Jürgen

IPC分类号： B65D75/58

CPC分类号： A61F15/001

摘要： The invention relates to a device for improving the removability of flat substrate sections (2) which are situated on carrier films (1), provided with a pressure-sensitive layer and which are packaged in pouches (3).

公开(公告)号：EP1007049A1

公开(公告)日：2000-06-14

申请号：EP98947467.1

申请日：1998-08-27

申请人： Hexal AG

发明人： STRUENGMANN, Andreas ,  FREUDENSPRUNG, Brigitte ,  KLOKKERS, Karin

IPC分类号： A61K31/54 ,  A61K47/26 ,  A61K47/38 ,  A61K47/40

CPC分类号： B82Y5/00 ,  A61K9/0007 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0095 ,  A61K9/02 ,  A61K9/145 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/2059 ,  A61K9/209 ,  A61K31/5415 ,  A61K47/10 ,  A61K47/6951

摘要： Pharmaceutical compositions containing enolic carboxamide type antiinflammatory agent meloxicam that exhibit improved wettability, aqueous solubility, dissolution behaviour over a broad range of pH, and that are prepared by crystal structure modification of the drug through dry or wet mechanical homogenization with two further components - one of them is selected from a group of oligo - and dissolution improving, or alkalizing agent. The application of the formulations according to the present invention results in an improved biovailability and effectiveness of meloxicam.

公开(公告)号：EP0724452B1

公开(公告)日：2000-05-24

申请号：EP94928852.6

申请日：1994-09-30

申请人： HEXAL AG

发明人： KLOKKERS, Karin ,  FISCHER, Wilfried

IPC分类号： A61K38/13 ,  A61K9/48 ,  A61K47/22

CPC分类号： A61K9/0014 ,  A61K9/0019 ,  A61K9/4858 ,  A61K38/13 ,  A61K47/22 ,  A61K31/355 ,  A61K2300/00

摘要： The invention concerns a pharmaceutical composition which consists of or contains cyclosporine A and α-tocopherol or one of its derivatives.

公开(公告)号：EP0921793A1

公开(公告)日：1999-06-16

申请号：EP98916917.0

申请日：1998-03-11

申请人： HEXAL AG

发明人： KLOKKERS, Karin

IPC分类号： A61K9 ,  A61K31 ,  A61K47 ,  A61P25

摘要： Non-deliquescent formulation comprising or consisting of sodium valproate and cyclodextrin having a molar ratio of sodium valproate to cyclodextrin within the range of from 1:0.01 to 1:0.09.