公开(公告)号：EP0833595B1

公开(公告)日：2003-10-01

申请号：EP96919181.6

申请日：1996-06-07

申请人： ST. JUDE MEDICAL, INC.

发明人： GIRARD, Michael, J. ,  CAMPBELL, Todd, D. ,  MIRSCH, M., William, II ,  SWANSON, Kristen, L.

IPC分类号： A61F2/24

CPC分类号： A61F2/2418

摘要： A stent for receiving and supporting a tissue heart valve for ultimate implantation into a human, the heart valve including tissue leaflets joined at circumferentially spaced commissures, wherein the stent includes at least one commissure support post and at least one sinus support structure each sinus support structure being disposed between but not functionally connected to an adjacent commissure support post.

公开(公告)号：EP1337386A2

公开(公告)日：2003-08-27

申请号：EP01988158.0

申请日：2001-11-21

申请人： ST. JUDE MEDICAL, INC.

发明人： KURK, James, L. ,  CAI, Chad, Q. ,  KRUSE, Steven, D. ,  WOO, Yi-Ren

IPC分类号： B29C33/42

CPC分类号： B29C41/14 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2475 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0029 ,  B29C33/42 ,  B29L2031/7534 ,  Y10S264/60

摘要： Improved dip coating methods and mandrels for forming polymer leaflets and valve prostheses are disclosed. The mandrel (300) has a top surface and an outer surface comprising a plurality of ridges (306) and contoured surfaces (310) extending to the ridges (306). An edge (312) on the mandrel (300) separates the top surface (314) and the contoured surfaces (310), with the mandrel edge (312) corresponding to the free edge of the leaflet. In preferred embodiments, the edge (312) separating the top surface (314) from the contoured surfaces (310) is sharp. The polymer formed on the top surface (314) can be efficiently separated from the remaining portions of the polymer structure to form the free edges of the leaflets.

公开(公告)号：EP1337202A1

公开(公告)日：2003-08-27

申请号：EP01998283.4

申请日：2001-11-16

申请人： ST. JUDE MEDICAL, INC.

发明人： PAN, Karl, K. ,  RINGDAL, James, R. ,  KRUSE, Steven, D.

IPC分类号： A61F2/24

CPC分类号： A61F2/2403

摘要： A prosthetic heart valve (10) for replacing a native heart valve is provided and includes a generally circular heart valve body (12) having an inner wall (14) defining a lumen (16) configured to allow blood flow therethrough. Occluders (40, 42) are configured to rotate about opposed occluder ends between an open position and a closed position. Minor radius arcs (24) in the body (12) cooperate with the occluders (40, 42) to allow the occluders (40, 42) to block blood flow through lumen when in a closed position yet provide an increased lumen (16) when the occluders (40, 42) are in an open position.

公开(公告)号：EP1306096A2

公开(公告)日：2003-05-02

申请号：EP02257433.9

申请日：2002-10-25

申请人： ST. JUDE MEDICAL, INC.

发明人： Woo, Yi-Ren ,  Pandit, Abhay

IPC分类号： A61L27/56 ,  A61L27/52 ,  A61F2/24

CPC分类号： A61L27/52 ,  A61F2/2403 ,  A61F2/2406 ,  A61F2/2475 ,  A61L27/56

摘要： An implantable prosthesis can be formed from an improved biocompatible material that provides for cellular colonization of the biocompatible material. Specifically, the biocompatible material is a rigid porous material. In embodiments of particular interest, the implantable prosthesis is a mechanical heart valve prosthesis with a rigid occluder. In some embodiments, the rigid occluder is formed from the biocompatible material. A filler comprising a hydrogel or a structural protein can be located within the pores. In some embodiments, a bioactive agent is within the pores. In some embodiments, the rigid occluder is formed from a polymer material, a carbonaceous solid or a ceramic material. The pores can extend through the rigid material.

摘要翻译： 可植入假体可以由提供生物相容性材料的细胞定植的改进的生物相容性材料形成。 具体地，生物相容性材料是刚性多孔材料。 在特别感兴趣的实施例中，可植入假体是具有刚性封堵器的机械心脏瓣膜假体。 在一些实施例中，刚性封堵器由生物相容性材料形成。 包含水凝胶或结构蛋白的填料可以位于孔内。 在一些实施方案中，生物活性剂在孔内。 在一些实施例中，刚性封堵器由聚合物材料，碳质固体或陶瓷材料形成。 孔可延伸通过刚性材料。

公开(公告)号：EP1284657A2

公开(公告)日：2003-02-26

申请号：EP01937483.4

申请日：2001-05-16

申请人： ST. JUDE MEDICAL, INC.

发明人： KUEHN, Stephen, T. ,  MONTPETIT, Karen, M.

IPC分类号： A61B17/00 ,  A61B17/064 ,  A61B17/128

CPC分类号： A61B17/1285 ,  A61B17/00234 ,  A61B17/0643 ,  A61B2017/00243 ,  A61B2017/003 ,  A61B2017/00314 ,  A61B2017/00327 ,  A61B2017/00464 ,  A61B2017/00783 ,  A61B2017/0647 ,  A61B2017/2905 ,  A61B2017/2912

摘要： An improved device (100) for performing medial procedures, preferably minimally invasive medical procedures, preferably minimally invasive medical procedures, includes a shaft (104) with a proximal and distal end and a bendable tip (108) extending from the distal end of the shaft (104). In some preferred embodiments, a fastener applicator (112) extends form the bendable tip (108). In other preferred embodiments, a malleable section (106) is located between the bendable tip (108) and the shaft (104). The bendable tip (108) can include a plurality of articulating segments (148, 150). The improved directional device can be used to repair native valves in a patient, especially heart valves.

公开(公告)号：EP1248655A1

公开(公告)日：2002-10-16

申请号：EP00986724.3

申请日：2000-12-22

申请人： ST. JUDE MEDICAL, INC.

发明人： ASHWORTH, Paul, E. ,  OGLE, Matthew, F. ,  MCTAVISH, Daniel, P. ,  KELLY, Sheila, J. ,  JOHNSON, Andrea, L.

IPC分类号： A61L27/36

CPC分类号： A61L27/507 ,  A61F2/06 ,  A61F2/2412 ,  A61L27/3687 ,  A61L2430/40

摘要： Crosslinked tissue is contacted with one or more toxicity reducing solutions to remove cytotoxicity associated with the crosslinking process. In particular, crosslinked tissue can be contacted with an inorganic sulfur-oxygen group to form chemical adducts of aldehydes and the inorganic sulfur-oxygen group. Preferably, the cytotoxicity reduced crosslinked tissue has no residual cytotoxicity. In preferred embodiments, a plurality of toxicity reducing agents are used to detoxify the tissue. Preferred toxicity reducing agents include, for example, inorganic sulfur-oxygen ions, such as bisulfate and thiosulfate, organic sulfates, amines, ammonia/ammonium, and surfactants.

公开(公告)号：EP1073387A1

公开(公告)日：2001-02-07

申请号：EP99921408.3

申请日：1999-04-19

申请人： ST. JUDE MEDICAL, INC.

发明人： BUCHANAN, Eric, S. ,  ALLAN, Bob ,  GIRARD, Michael, J. ,  HOLMBERG, William, R. ,  ANDERSON, Kimberly, A.

IPC分类号： A61F2/24

CPC分类号： A61F2/2427 ,  A61B17/064 ,  A61B17/068 ,  A61B17/072 ,  A61B17/1155 ,  A61B2017/0649 ,  A61B2017/07214 ,  A61F2/2409 ,  A61F2250/006

摘要： A prosthetic heart valve (10) for implantation in a heart includes an outer orifice ring (14) for coupling to a tissue annulus of a heart (42). An inner orifice ring (12) includes at least one leaflet occluder (18) carried in a lumen (22) of the inner orifice ring (12) which is movable between an open position, which allows blood flow through the lumen (22), and a closed position which blocks blood flow through the lumen (22). The inner orifice ring (12) is adapted to be coupled to the outer orifice ring (14) after the outer orifice ring (14) has been attached to the tissue annulus (48).

公开(公告)号：EP1053031A2

公开(公告)日：2000-11-22

申请号：EP99904400.1

申请日：1999-01-27

申请人： ST. JUDE MEDICAL, INC.

发明人： SCHROEDER, Richard, F. ,  OGLE, Matthew, F.

IPC分类号： A61L17/00 ,  A61L27/00

CPC分类号： A61L27/50 ,  A61L27/042 ,  A61L27/047 ,  A61L2400/02

摘要： Medical articles can include biocompatible material with a deposit of anticalcific elemental metal. The biocompatible material can be tissue, fabric or the like. The biocompatible material can be configured on the medical article such that when the medical article is positioned for its intended use, the biocompatible material is substantially removed from blood flow or is in a low blood flow area effectively removed from vascular blood flow. Gas phase or solution phase methods can be used to deposit the anticalcific elemental metal.

公开(公告)号：EP1011742A1

公开(公告)日：2000-06-28

申请号：EP97954233.9

申请日：1997-12-31

申请人： ST. JUDE MEDICAL, INC.

发明人： HEALY, Steven, J. ,  SCHROEDER, Richard, F.

IPC分类号： A61L27/00 ,  A61F13/02 ,  A61B17/11 ,  A61F2/16 ,  A61F2/06 ,  A61F2/24

CPC分类号： A61F2/2415 ,  A61B2090/3937 ,  A61F2/06 ,  A61F2/07 ,  A61F2/08 ,  A61F2/2433 ,  A61F2/2445 ,  A61F2220/0075 ,  A61F2250/0087 ,  A61F2250/0097 ,  A61L27/50 ,  A61L27/507 ,  Y10S623/904 ,  Y10S623/91

摘要： A prosthetic stentless aortic tissue valve (10A) includes a substantially annular valve body (12) having a leaflet (34) carried therein for occluding blood flow therethrough. A root (14) extends generally coaxially from the valve body (12). Visual markings (28) are provided on the root and act as a sculpting guide for a surgeon during implantation of the prosthetic heart valve (10A) to sculpt portions of sinus areas of the root.

公开(公告)号：EP0853466A1

公开(公告)日：1998-07-22

申请号：EP96933002.0

申请日：1996-09-09

申请人： ST. JUDE MEDICAL, INC.

发明人： KRUEGER, Kurt, D. ,  GIRARD, Michael, J. ,  VANNEY, Guy, P.

IPC分类号： A61M1 ,  A61F2

CPC分类号： A61F2/2427

摘要： A manipulable low profile heart valve holder (12) that can be pivotally attached to a handle (22) that permits the heart valve holder (12) and a retained heart valve prosthesis (13) to be manipulated remotely during implantation. The heart valve holder (12) is pivotable from a position wherein the plane of the orifice of a retained heart valve (13) is parallel to the axis of the handle (22), to a second position wherein the plane of the retained heart valve (13) is substantially 90° to the axis of the handle (22). This pivoting arrangement particularly aids in manipulation of the heart valve prosthesis (13) during implantation using trocars for access to the body cavity. Manipulation is accomplished by having controllable elements on the handle (22) and retained on the exterior of the patient. Manipulation of the heart valve holder (12) also may be done through separate instruments operating through separate trocars.