公开(公告)号：EP1306096A2

公开(公告)日：2003-05-02

申请号：EP02257433.9

申请日：2002-10-25

申请人： ST. JUDE MEDICAL, INC.

发明人： Woo, Yi-Ren ,  Pandit, Abhay

IPC分类号： A61L27/56 ,  A61L27/52 ,  A61F2/24

CPC分类号： A61L27/52 ,  A61F2/2403 ,  A61F2/2406 ,  A61F2/2475 ,  A61L27/56

摘要： An implantable prosthesis can be formed from an improved biocompatible material that provides for cellular colonization of the biocompatible material. Specifically, the biocompatible material is a rigid porous material. In embodiments of particular interest, the implantable prosthesis is a mechanical heart valve prosthesis with a rigid occluder. In some embodiments, the rigid occluder is formed from the biocompatible material. A filler comprising a hydrogel or a structural protein can be located within the pores. In some embodiments, a bioactive agent is within the pores. In some embodiments, the rigid occluder is formed from a polymer material, a carbonaceous solid or a ceramic material. The pores can extend through the rigid material.

摘要翻译： 可植入假体可以由提供生物相容性材料的细胞定植的改进的生物相容性材料形成。 具体地，生物相容性材料是刚性多孔材料。 在特别感兴趣的实施例中，可植入假体是具有刚性封堵器的机械心脏瓣膜假体。 在一些实施例中，刚性封堵器由生物相容性材料形成。 包含水凝胶或结构蛋白的填料可以位于孔内。 在一些实施方案中，生物活性剂在孔内。 在一些实施例中，刚性封堵器由聚合物材料，碳质固体或陶瓷材料形成。 孔可延伸通过刚性材料。

公开(公告)号：EP2030750A1

公开(公告)日：2009-03-04

申请号：EP08011640.3

申请日：2001-11-21

申请人： St. Jude Medical, Inc.

发明人： Kurk, James L. ,  Cai, Chad Q. ,  Kruse, Steven.D ,  Woo, Yi-Ren

IPC分类号： B29C33/42 ,  B29C41/14 ,  A61F2/24

CPC分类号： B29C41/14 ,  A61F2/2412 ,  A61F2/2415 ,  A61F2/2475 ,  A61F2210/0076 ,  A61F2240/001 ,  A61F2250/0029 ,  B29C33/42 ,  B29L2031/7534 ,  Y10S264/60

摘要： Improved dip coating methods and mandrels for forming polymer leaflets and valve prostheses are disclosed. The mandrel (300,324,350) has a top surface and an outer surface comprising a plurality of ridges (306,402) and contoured surfaces extending to the ridges. An edge (312) on the mandrel separates the top surface and the contoured surfaces, with the mandrel edge corresponding to the free edge of the leaflet. In preferred embodiments, the edge separating the top surface from the contoured surfaces is sharp. The polymer formed on the top surface can be efficiently separated from the remaining portions of the polymer structure to form the free edges of the leaflets.

摘要翻译： 公开了用于形成聚合物小叶和瓣膜假体的改进的浸涂方法和心轴。 心轴（300,324,350）具有顶表面和包括多个脊（306,402）的外表面和延伸到脊的轮廓表面。 心轴上的边缘（312）分离顶表面和轮廓表面，其中心轴边缘对应于传单的自由边缘。 在优选实施例中，将顶表面与轮廓表面分开的边缘是锋利的。 形成在顶表面上的聚合物可以有效地与聚合物结构的其余部分分离，以形成传单的自由边缘。

公开(公告)号：EP1306096A3

公开(公告)日：2004-04-07

申请号：EP02257433.9

申请日：2002-10-25

申请人： ST. JUDE MEDICAL, INC.

发明人： Woo, Yi-Ren ,  Pandit, Abhay

IPC分类号： A61L27/56 ,  A61L27/52 ,  A61F2/24

CPC分类号： A61L27/52 ,  A61F2/2403 ,  A61F2/2406 ,  A61F2/2475 ,  A61L27/56

摘要： An implantable prosthesis can be formed from an improved biocompatible material that provides for cellular colonization of the biocompatible material. Specifically, the biocompatible material is a rigid porous material. In embodiments of particular interest, the implantable prosthesis is a mechanical heart valve prosthesis with a rigid occluder. In some embodiments, the rigid occluder is formed from the biocompatible material. A filler comprising a hydrogel or a structural protein can be located within the pores. In some embodiments, a bioactive agent is within the pores. In some embodiments, the rigid occluder is formed from a polymer material, a carbonaceous solid or a ceramic material. The pores can extend through the rigid material.