公开(公告)号：EP1883619B1

公开(公告)日：2013-03-20

申请号：EP06768635.2

申请日：2006-05-25

申请人： Choongwae Pharma Corporation

发明人： HWANG, Tae-Seop, 313-303, Cheongmyeong Maeul ,  KIM, Hyun-Gyu

IPC分类号： C07C227/04 ,  C07C229/64 ,  C07C251/24

CPC分类号： C07C227/04 ,  C07C229/64 ,  C07C251/24

公开(公告)号：EP2357166A4

公开(公告)日：2012-07-04

申请号：EP09827243

申请日：2009-11-20

申请人： IHI CORP ,  ISHIKAWA YOSHIHIRO

发明人： ISHIKAWA YOSHIHIRO ,  EGUCHI HARUKI

IPC分类号： C07C251/24 ,  A61K31/135 ,  A61K31/167 ,  A61K31/295 ,  A61K31/337 ,  A61P35/00 ,  C07D305/14

CPC分类号： C07D305/14 ,  A61K31/135 ,  A61K31/167 ,  A61K31/295 ,  A61K31/337 ,  C07C251/24

摘要： The present invention provides a drug using the magnetic properties of a metal salen complex as represented by the following general formula in order to magnetize the intended drug by chemically binding the drug to a metal salen complex so that the drug can be delivered to the target diseased site. The drug can be delivered to the diseased site using the magnetic properties of the drug per se without using a carrier made of a magnetic substance as in the conventional methods.

摘要翻译： 本发明提供一种使用如以下通式表示的金属盐配合物的磁性的药物，以便通过将药物化学结合到金属盐配合物来磁化预期的药物，使得药物可以递送到目标患者 现场。 药物可以使用药物本身的磁性能被递送到患病部位，而不使用如在常规方法中的由磁性物质制成的载体。

公开(公告)号：EP2460788A1

公开(公告)日：2012-06-06

申请号：EP10804541.0

申请日：2010-07-30

申请人： Sumitomo Chemical Company, Limited ,  Tokyo Institute of Technology

发明人： IKEDA Tomiki ,  KINOSHITA Motoi ,  NAM Yunmi

IPC分类号： C07C251/24 ,  C09K11/06 ,  H01L51/50 ,  C07F15/00

CPC分类号： C07F15/0033 ,  C07C251/24 ,  C07C2601/14 ,  C07F15/004 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/185 ,  H01L51/0085 ,  H01L51/0087 ,  H01L51/5016 ,  H01L51/5293

摘要： The invention provides a metal complex having a structure represented by the following formula (1):

wherein M represents a metal atom such as copper; C 1 and C 2 are each an sp3 carbon atom; A 1 -A 4 each independently represent hydrogen, etc; this is with the proviso that A 1 and A 3 may bond together to form a C4 or greater alkylene group and form a ring together with C 1 and C 2 ; the alkylene group may be optionally substituted; R 0 -R 7 each independently represent hydrogen, etc; Z represents a monovalent monodentate ligand, and p is the number of monodentate ligands, represented by ("valency of central metal atom M" - 2).

摘要翻译： 本发明提供具有由下式（1）表示的结构的金属络合物：其中M表示金属原子如铜; C 1和C 2各自为sp 3碳原子; A 1 -A 4各自独立地表示氢等; 这是条件是A 1和A 3可以一起键合形成C4或更大的亚烷基并与C 1和C 2一起形成环; 亚烷基可以任选被取代; R 0 -R 7各自独立地表示氢等; Z表示单价单齿配体，p是由（“中心金属原子M”-2的化合价）表示的单齿配体的数目。

公开(公告)号：EP1629063A4

公开(公告)日：2012-03-07

申请号：EP04735658

申请日：2004-06-01

申请人： FUJIFILM CORP

发明人： NII KAZUMI ,  WATANABE KOUSUKE ,  IGARASHI TATSUYA ,  ICHIJIMA SEIJI ,  ISE TOSHIHIRO

IPC分类号： C09K11/06 ,  C07C251/24 ,  C07D207/20 ,  C07D213/22 ,  C07D213/53 ,  C07D213/74 ,  C07D471/04 ,  C07F15/00 ,  H05B33/14

CPC分类号： H01L51/0087 ,  C07C251/24 ,  C07D213/22 ,  C07D213/53 ,  C07F15/0093 ,  C09K11/06 ,  C09K2211/1029 ,  C09K2211/1037 ,  C09K2211/1044 ,  C09K2211/1059 ,  C09K2211/1092 ,  C09K2211/182 ,  C09K2211/185 ,  H01L51/5012 ,  H01L51/5203 ,  H05B33/14 ,  Y10S428/917

摘要： An organic electroluminescent device, which has a pair of electrodes and at least one organic layer including a luminescent layer between the pair of electrodes, wherein at least one layer between the pair of electrodes comprises at least one metal complex having a tridentate- or higher polydentate-chain structure ligand.

公开(公告)号：EP2163538B1

公开(公告)日：2012-01-25

申请号：EP08748526.4

申请日：2008-05-22

申请人： Topharman Shanghai Co., Ltd. ,  Weifang Tehua Chemical Co., Ltd.

发明人： ZHU, Fuqiang ,  LI, Haihong ,  WANG, Wenzhong ,  ZHANG, Hui ,  SHEN, Jingshan

IPC分类号： C07C209/52 ,  C07C211/29 ,  C07C233/13 ,  C07C251/24 ,  C07D243/14

CPC分类号： C07C211/29 ,  C07C209/52 ,  C07C233/13 ,  C07C251/24 ,  C07D243/14

摘要： Preparation methods of 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine and their intermediates. Compounds represented by the formula I and II. The preparation methods of 4-acetyl-2,3,4,5-tetrahydro-benzo[1,4]diazepine in which compounds represented by the formula I and II and o-nitrobenzaldehyde are used. These methods are absolutely novel synthetic routes for preparation of 4-acetyl-2,3,4,5-tetrahydro -benzo[1,4] diazepine. The routes are short and easy to operate and raw materials are readily available. The routes are economical and safe without using costly and unsafe lithium aluminium hydride.

公开(公告)号：EP2307477A2

公开(公告)日：2011-04-13

申请号：EP09803153.7

申请日：2009-07-29

申请人： SK Energy Co., Ltd.

发明人： OK, Myungahn ,  JEONG, Ji Su ,  LEE, Bun Yeoul ,  SUJITH, S ,  ANISH, Cyriac ,  MIN, Jea Ki ,  SEONG, Jong Eon

IPC分类号： C08G64/20 ,  C08G64/34 ,  C08G64/32 ,  C07C251/24 ,  C07C39/04

CPC分类号： C08G64/34 ,  C07C37/16 ,  C07C39/24 ,  C07C45/00 ,  C07C45/63 ,  C07C45/68 ,  C07C249/02 ,  C07C251/24 ,  C07C2601/14 ,  C07F15/065 ,  C07C47/565

摘要： Provided are a complex prepared from ammonium salt-containing ligands and having such an equilibrium structural formula that the metal center takes a negative charge of 2 or higher, and a method for preparing polycarbonate via copolymerization of an epoxide compound and carbon dioxide using the complex as a catalyst. When the complex is used as a catalyst for copolymerizing an epoxide compound and carbon dioxide, it shows high activity and high selectivity and provides high-molecular weight polycarbonate, and thus easily applicable to commercial processes. In addition, after forming polycarbonate via carbon dioxide/epoxide copolymerization using the complex as a catalyst, the catalyst may be separately recovered from the copolymer.

公开(公告)号：EP2233468A4

公开(公告)日：2010-12-22

申请号：EP08858485

申请日：2008-12-10

申请人： NISSAN CHEMICAL IND LTD

发明人： SHIBASAKI MASAKATSU ,  MATSUNAGA SHIGEKI ,  CHEN ZHIHUA

IPC分类号： C07C251/24 ,  C07B53/00 ,  C07B61/00 ,  C07C269/00 ,  C07C269/06 ,  C07C271/22 ,  C07D307/33 ,  C07D307/54 ,  C07D333/24 ,  C07F15/04

CPC分类号： C07C269/06 ,  C07B53/00 ,  C07B2200/07 ,  C07C2601/08 ,  C07D307/33 ,  C07D307/54 ,  C07D333/24 ,  C07C271/22

公开(公告)号：EP1931629B1

公开(公告)日：2010-12-22

申请号：EP06805861.9

申请日：2006-09-26

申请人： Novartis AG

发明人： MICKEL, Stuart, John ,  MARTERER, Wolfgang

IPC分类号： C07D207/16 ,  C07C251/24 ,  C07C237/22

CPC分类号： C07C251/24 ,  C07C231/12 ,  C07D207/08 ,  C07D207/16 ,  C07C237/22

摘要： The invention related to a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a process for the manufacture of a compound of the formula (III), wherein R, R1, and R' are as defined in the specification, or a salt thereof, and a compound of formula (IV) wherein R, R1, R2 and R' are as defined in the specification, and processes of manufacturing these.

公开(公告)号：EP1484301B1

公开(公告)日：2010-08-11

申请号：EP03708516.4

申请日：2003-03-07

申请人： SHIONOGI & CO., LTD.

发明人： KAWANISHI, Yasuyuki ,  UENAKA, Masaaki ,  MATSUURA, Munenori

IPC分类号： C07C33/44 ,  C07C311/07 ,  C07C303/36 ,  C07C303/40 ,  C07C313/06 ,  C07C227/32 ,  C07C229/46 ,  C07C251/24 ,  C07D265/30 ,  C07D401/04 ,  C07D213/75 ,  C07D277/82

CPC分类号： C07D209/48 ,  C07B2200/07 ,  C07C227/32 ,  C07C229/48 ,  C07C249/02 ,  C07C251/24 ,  C07C303/40 ,  C07C313/06 ,  C07C2601/14 ,  C07D213/75 ,  C07D215/38 ,  C07D233/88 ,  C07D265/30 ,  C07D275/03 ,  C07D277/82 ,  C07D295/135 ,  C07D311/14 ,  C07D319/18 ,  C07D401/04 ,  C07D413/04 ,  C07C311/07

摘要： A process for producing a compound (I) which comprises the step of reacting a compound (II) with a base in an aprotic solvent as shown by the scheme: (II) (I) wherein R1 and R2 each independently represents lower alkyl.

摘要翻译： （II）（I）其中R 1和R 2各自独立地代表低级烷基的方法，该方法包括使化合物（II）与碱在非质子传递溶剂中反应的步骤。

公开(公告)号：EP2078710A4

公开(公告)日：2010-08-04

申请号：EP07830038

申请日：2007-10-11

申请人： SUMITOMO CHEMICAL CO

发明人： HIRATA NORIHIKO ,  YOSHIMIYA TAKANORI ,  IWANAGA YOSHIHIKO

IPC分类号： C07C249/02 ,  C07B53/00 ,  C07C251/24 ,  C07F1/08

CPC分类号： C07B53/00 ,  C07C249/02 ,  C07C251/24