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    PROCESS FOR FEEDING FISH, FISH MEAT AND FOOD PRODUCT
    101.
    发明公开
    PROCESS FOR FEEDING FISH, FISH MEAT AND FOOD PRODUCT 有权
    VERFAHREN ZUMFÜTTERNVON FISCHEN，FISCHFLEISCH UND NAHRUNGSMITTELPRODUKT

    公开(公告)号：EP3091850A1

    公开(公告)日：2016-11-16

    申请号：EP14799520.3

    申请日：2014-08-29

    申请人： Nemzeti Agrárkutatási És Innovációs Központ (Naik)

    发明人： CSENGERI, István ,  RÓNYAI, András ,  NAGYNÉ BÍRÓ, Janka ,  FELEDI, Tibor ,  ADORJÁN, Ágnes ,  MOLNÁR, Judit ,  PERCZE, Vanda

    IPC分类号： A23L2/00

    CPC分类号： A23K50/80 ,  A23K20/158 ,  A23L17/00

    摘要： The invention provides a process for the feeding of fish, comprising at least two consecutive stages: stage I: feeding juvenile fish with a feed having high protein and low fat content, thereby preferably decreasing the level of saturated and monounsaturated fatty acids in said fish meat relative to the weight of the fish; and then stage II: feeding juvenile fish with a feed having a fatty acid content of increased level(s) of one or more long chain polyunsaturated fatty acid(s) (LcPUFA), to deposit the one or more LcPUFA in the fish meat, thereby preferably increasing the level(s) of said fatty acid(s) relative to the weight of the fish. The invention further provides a fish meat food product containing the flesh of a fish fed by the process of the invention, said food product being functional food and further provides a kit of feeds for the feeding of fish, comprising feeds that may be used in stage I and II, defined above. Using the process to produce the fish meat serving as the basis of the functional food, the fatty acid composition of the fish meat may be influenced more favourably in respect of arachidonic acid (ARA), eicosapen- taenoic acid (EPA and docosahexaenoic acid (DHA) than by methods used earlier.

    摘要翻译： 本发明提供了一种喂养鱼的方法，其包括至少两个连续阶段：阶段I：向幼鱼喂养具有高蛋白质和低脂肪含量的饲料，从而优选降低所述鱼肉中饱和和单不饱和脂肪酸的含量 相对于鱼的重量; 然后第二阶段：用一种或多种长链多不饱和脂肪酸（LcPUFA）的脂肪酸含量增加的饲料喂养幼鱼，以将一种或多种LcPUFA沉积在鱼肉中， 从而优选增加所述脂肪酸相对于鱼的重量的水平。 本发明还提供一种鱼肉食品，其含有通过本发明的方法喂养的鱼的肉，所述食品是功能性食品，并且还提供用于饲喂鱼的饲料包，其包括可用于阶段的饲料 I和II，定义如上。 利用该方法生产作为功能食品基础的鱼肉，鱼油的脂肪酸组成可能更有利于花生四烯酸（ARA），二十碳五烯酸（EPA和二十二碳六烯酸（DHA） ）比以前使用的方法。

    APPARATUS FOR ON DEMAND LIMITING OF THE VALUE RANGE OF A PARAMETER ADJUSTMENT DEVICE
    105.
    发明公开
    APPARATUS FOR ON DEMAND LIMITING OF THE VALUE RANGE OF A PARAMETER ADJUSTMENT DEVICE 审中-公开
    DEVICE对于买家JUST限制区参数设备的价值观

    公开(公告)号：EP2807492A1

    公开(公告)日：2014-12-03

    申请号：EP12859367.0

    申请日：2012-12-19

    申请人： Tóth, Mátyás ,  Szoboszlay, Balázs

    发明人： Tóth, Mátyás ,  Szoboszlay, Balázs

    IPC分类号： G01R17/20 ,  H01C10/00 ,  G05G5/02

    CPC分类号： G05G1/10 ,  G05G5/00 ,  G05G5/02 ,  H01C10/14 ,  Y10T74/2084

    摘要： The modified nut that consists of a lower fixed nut (2) and a rotating shim (5), is being fixed on the threaded collar or other fix part of a potentiometer. The modified nut is only capable of a rotating movement - clockwise or counterclockwise direction depending on the way of assembly of the rotating shim (5) - that is limited by the built-in-stops (3) (6), where the rotating shim (5) can turn from its standstill point in the permitted direction when a force is applied to it, and when such force is terminated it returns to its begining standstill point. To provide the returning force, one end of the pulling spring (4) is attached to the lower fixed nut (2) while the other end is attached to the rotating shim (5). A modified potentiometer knob is fixed to the rotating shaft of the potentiometer (1), this knob consists of an external knob part (7), an internal knob part (9), a pressing spring (8) and a locking cap (10). The internal knob part (9)fixed to the rotating shaft of the potentiometer (1) with (11) grub-screw. The pressing spring (8) creates a pressing force between the internal knob part (9) and the external knob part (7), in pulled up inactive position, there is no connection between the rotating shim (5) and the external knob part (7) can move independently of the rotating shim (5) In switched on active position, it can move connected to the rotating shim (5). When the external knob part (7) can be rotated independently of the rotating shim (5), the rotating shaft of the potentiometer (1) can move between its own minimum and maximum values. The value of the potentiometer set at the moment the external knob part (7) and the rotating shim (5) are connected will be the new minimum or new maximum values of the potentiometer value range.

    A COMPOSITION COMPRISING REDUCED GLUTATHIONE AND ACETAMINOPHEN AND PREPARATION METHOD THEREOF
    107.
    发明公开
    A COMPOSITION COMPRISING REDUCED GLUTATHIONE AND ACETAMINOPHEN AND PREPARATION METHOD THEREOF 审中-公开
    ZUSAMMENSETZUNG MIT REDUZIERTEM GLUTATHION- UND ACETAMINOPHENGEHALT UND HERSTELLUNGSVERFAHRENDAFÜR

    公开(公告)号：EP2769717A1

    公开(公告)日：2014-08-27

    申请号：EP12881084.3

    申请日：2012-07-12

    申请人： Hainan Wei-Kang Pharmaceutical (Qianshan) Company Limited

    发明人： WANG, Liuyi ,  WANG, Jincan

    IPC分类号： A61K31/167 ,  A61K38/06 ,  A61K9/08 ,  A61K9/107 ,  A61K9/16 ,  A61K9/20 ,  A61K9/48 ,  A61P1/16 ,  A61P25/04 ,  A61P39/02

    CPC分类号： A61K38/063 ,  A61K9/0095 ,  A61K9/08 ,  A61K9/1652 ,  A61K9/2077 ,  A61K31/167 ,  A61K47/40 ,  B29B9/12 ,  A61K2300/00

    摘要： The invention relates to a pharmaceutical composition of glutathione and acetaminophen and preparation method thereof. The active ingredients of the composition include glutathione with composition ration of 0.1% ∼ 99.9% and acetaminophen with composition ratio of 99.9% ∼ 0.1%. The further purpose of the invention is to prepare glutathione and acetaminophen composition (raw materials) into various pharmaceutically acceptable dosage forms, such as tablets, sustained/controlled release preparations, capsules, pills, syrups, films, granules, oral solutions, oral suspensions, oral emulsions and oral powders. The beneficial effects of the invention is reflected in that glutathione and acetaminophen combination can effectively prevent the liver cell damage and necrosis caused by acetaminophen overdose and is strongly in favor of cancer pain relieving and chemotherapy.

    摘要翻译： 本发明涉及谷胱甘肽和对乙酰氨基酚的药物组合物及其制备方法。 组合物的活性成分包括组成比为0.1％¼99.9％的谷胱甘肽和组合比为99.9％¼0.1％的对乙酰氨基酚。 本发明的另一个目的是将谷胱甘肽和对乙酰氨基酚组合物（原料）制备成各种药学上可接受的剂型，例如片剂，持续/控释制剂，胶囊，丸剂，糖浆，薄膜，颗粒，口服溶液，口服悬浮液， 口服乳液和口服粉剂。 本发明的有益效果体现在谷胱甘肽和对乙酰氨基酚组合可以有效预防肝细胞损伤和对乙酰氨基酚过量引起的坏死，并且强烈有利于癌症缓解和化疗。

    USE OF A HALF-TRANSPORTER PROTEIN OF THE ABCG-FAMILY FOR SELECTING CELLS AND IN GENE THERAPY
    109.
    发明授权
    USE OF A HALF-TRANSPORTER PROTEIN OF THE ABCG-FAMILY FOR SELECTING CELLS AND IN GENE THERAPY 有权
    使用一半的转运蛋白的ABCG家族小区选择和基因治疗

    公开(公告)号：EP1442057B1

    公开(公告)日：2012-06-13

    申请号：EP02777580.8

    申请日：2002-10-24

    申请人： Creative Cell Kft.

    发明人： NEMET, Katalin ,  VARADI, György ,  CERVENAK, Judit ,  UJHELLY, Olga ,  SARKADI, Balázs ,  VARADI, András ,  ÖZVEGY, Csilla

    IPC分类号： C07K14/47 ,  C12N5/10 ,  A61K48/00 ,  C12N15/12 ,  C12N15/86 ,  C12N15/867

    CPC分类号： C12N5/0647 ,  A61K48/00 ,  A61K2035/124 ,  C07K14/705 ,  C12N2510/00

    摘要： Using an isolated nucleic acid comprising a sequence encoding a half transporter protein of the ABCG-family, in gene therapy methods, and in selecting somatic mammalian cells using at least one drug transportable by the transporter protein, is new. Independent claims are also included for: (1) a vector for gene transfer into a mammalian cell, comprising the nucleic acid; (2) selecting somatic mammalian cells using at least one drug transportable by the transporter protein; (3) somatic mammalian cells transformed by the vector; (4) an infectious virion obtainable from a viral vector; and (5) a pharmaceutical kit comprising the vector. ACTIVITY : Immunosuppressive. No biological data given. MECHANISM OF ACTION : Gene therapy; Hematopoietic cell protector. After retroviral transduction the cells were exposed to 5mM Mitoxanthrone (MX) selection for 3 days and induced for granulocyte differentiation by G-CSF, or plated directly in a colony forming assay and selected by MX in methylcellulose. Normal or mock transduced CD34+ cells did not show measurable MX extrusion capacity, but a significant increase in MX extrusion was seen in the ABCG2-G transduced progenitor cells, and this extrusion was further increased by MX selection of the transduced cells. When MX was used as a selection agent the mock transduced cells did not form colonies, while the MX selection decreased the number in the ABCG2-G transduced cells by about 50%. This reduction closely corresponds to the elimination of the cells not expressing ABCG2-G.