公开(公告)号：EP3632336A1

公开(公告)日：2020-04-08

申请号：EP18804999.3

申请日：2018-05-16

申请人： Sumitomo Bakelite Co., Ltd. ,  National University Corporation Tokyo Medical and Dental University

发明人： ARAI, Hirokuni ,  SAKATE, Toshifumi ,  KAWAMATA, Akira ,  HARATA, Shinetsu

IPC分类号： A61B17/00 ,  A61B17/02

摘要： The present invention provides a coronary artery bypass surgery treatment tool or the like including a flexible tube, a suction cup in which an opening portion is formed to communicate with the flexible tube and which is provided at a distal end of the flexible tube, a joint portion which has a suction path, a male connector which is provided in one of a proximal end of the flexible tube and a distal end of the suction path of the joint portion, and a female connector which is provided in the other thereof and is detachably connected to the male connector.

公开(公告)号：EP3517610A1

公开(公告)日：2019-07-31

申请号：EP17853209.9

申请日：2017-09-25

申请人： National University Corporation Tokyo Medical and Dental University

发明人： YOKOTA Takanori ,  NAGATA Tetsuya

IPC分类号： C12N15/09 ,  A61K31/7088 ,  A61K31/711 ,  A61K47/22 ,  A61K47/28 ,  A61K47/50 ,  A61K48/00 ,  A61P25/00 ,  C12N15/113

摘要： The present invention provides a composition and a method for efficiently delivering a nucleic acid agent to the central nervous system and/or the retina and bringing about antisense effects. Provided is a composition for reducing the expression level of a target transcription product in the central nervous system and/or retina of a subject, the composition including a nucleic acid complex that includes a first nucleic acid strand and a second nucleic acid strand, wherein: the first nucleic acid strand comprises a base sequence capable of hybridizing with at least part of the target transcription product and has an antisense effect on the target transcription product; the second nucleic acid strand comprises a base sequence complementary to the first nucleic acid strand and is conjugated to tocopherol, cholesterol, or an analog thereof; and the first nucleic acid strand is annealed to the second nucleic acid strand.

公开(公告)号：EP3502248A1

公开(公告)日：2019-06-26

申请号：EP17839475.5

申请日：2017-08-08

申请人： National University Corporation Tokyo Medical and Dental University

发明人： OKAZAWA, Hitoshi ,  KAJIKAWA, Masunori

IPC分类号： C12N15/09 ,  A61K39/395 ,  A61P25/28 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N5/16 ,  C12P21/08

摘要： An anti-HMGB1 antibody comprising a light chain variable region comprising complementarity-determining regions or the like including amino acid sequences of SEQ ID NOs: 4 to 6, and a heavy chain variable region comprising complementarity-determining regions or the like including amino acid sequences of SEQ ID NOs: 10 to 12, or an anti-HMGB1 antibody comprising a light chain variable region or the like comprising an amino acid sequence of SEQ ID NO: 3, and a heavy chain variable region comprising an amino acid sequence or the like of SEQ ID NO: 9, and a composition for treating or preventing Alzheimer's disease, comprising the same as an active ingredient.

公开(公告)号：EP3192878B1

公开(公告)日：2019-05-22

申请号：EP15840654.6

申请日：2015-09-07

申请人： National University Corporation Tokyo Medical and Dental University ,  GC Lymphotec Inc.

发明人： SHIMIZU, Norio ,  TAKAHASHI, Hideyuki

IPC分类号： C12Q1/68 ,  C12N15/09

公开(公告)号：EP3456842A1

公开(公告)日：2019-03-20

申请号：EP17796169.5

申请日：2017-05-10

申请人： National University Corporation Tokyo Medical and Dental University ,  Nippon Zoki Pharmaceutical Co., Ltd.

发明人： ASAHARA, Hiroshi ,  CHIBA, Tomoki ,  ABE, Kentaro

IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12N15/09

摘要： Provided are an expression inhibitor of an inflammation promoting factor based on the discovery of a new factor influencing the expression amount/level of an inflammation promoting factor, and a development tool therefor. Provided are also a diagnostic agent and a diagnosis method for immune diseases, inflammatory diseases, painful conditions and similar. More specifically provided are: an expression inhibitor of an inflammation promoting factor containing at least one kind of inhibitor selected from the group consisting of RBMS2 expression inhibitor and RBMS2 function inhibitor; a screening method using as an indicator the expression or the function of RBMS2; an expression cassette useful for said method; as well as a diagnostic agent containing a product detection agent for RBMS2 gene expression and disease detection method using as an indicator RBMS2 gene expression amount/level.

公开(公告)号：EP2791335B1

公开(公告)日：2018-11-14

申请号：EP12815856.5

申请日：2012-12-17

申请人： National University Corporation Tokyo Medical and Dental University ,  Osaka University

发明人： YOKOTA, Takanori ,  NISHINA, Kazutaka ,  OBIKA, Satoshi ,  MIZUSAWA, Hidehiro

IPC分类号： C12N15/11 ,  C12N15/113 ,  A61K31/713

CPC分类号： C12N15/113 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/15 ,  C12N2310/3181 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/3513 ,  C12N2310/3515 ,  C12N2310/53 ,  C12N2320/52

摘要： A method of reducing the level of a transcription product in a cell comprising contacting with the cell a composition comprising a double-stranded nucleic acid complex comprising a first nucleic acid strand annealed to a second nucleic acid strand, wherein: (i) the first nucleic acid strand hybridizes to the transcription product and comprises (a) a region consisting of at least 4 consecutive nucleotides that are recognized by RNase H when the strand is hybridized to the transcription product, (b) one or more nucleotide analogs located on 5′ terminal side of the region, (c) one or more nucleotide analogs located on 3′ terminal side of the region and (d) a total number of nucleotides and nucleotide analogs ranging from 8 to 35 nucleotides and (ii) the second nucleic acid strand comprises (a) nucleotides and optionally nucleotide analogs and (b) at least 4 consecutive RNA nucleotides.

公开(公告)号：EP3124024A1

公开(公告)日：2017-02-01

申请号：EP15769927.3

申请日：2015-03-26

申请人： Kyoto University ,  National University Corporation Tokyo Medical and Dental University

发明人： HAGIWARA, Masatoshi ,  MOROOKA, Satoshi ,  HOSOYA, Takamitsu ,  YOSHIDA, Suguru

IPC分类号： A61K31/4152 ,  A61K31/519 ,  A61K45/00 ,  A61P27/02 ,  A61P27/06 ,  A61P35/00 ,  A61P43/00

CPC分类号： A61K31/519 ,  A61K9/0048 ,  A61K31/4152 ,  A61K45/06 ,  A61K2300/00

摘要： A pharmaceutical composition for neovascular diseases, a pharmaceutical composition for inhibiting an angiogenic growth factor, and use of these pharmaceutical compositions are provided.
In one or more embodiments, a pharmaceutical composition contains as an active ingredient a low molecular weight compound that is able to suppress the expression of the VEGF gene in cells or to reduce the production of VEGF protein from cells. In one or more embodiments, a pharmaceutical composition contains as an active ingredient a compound expressed by the following formula (I) or a prodrug thereof or pharmaceutically acceptable salts thereof

摘要翻译： 提供了用于新血管疾病的药物组合物，用于抑制血管生成生长因子的药物组合物，以及这些药物组合物的用途。 在一个或多个实施方案中，药物组合物含有作为活性成分的低分子量化合物，其能够抑制VEGF基因在细胞中的表达或减少来自细胞的VEGF蛋白质的产生。 在一个或多个实施方案中，药物组合物含有作为活性成分的由下式（I）表示的化合物或其前药或其药学上可接受的盐

公开(公告)号：EP2261370B1

公开(公告)日：2016-08-24

申请号：EP10164051.4

申请日：2010-05-27

申请人： Fujifilm Corporation ,  National University Corporation Tokyo Medical and Dental University

发明人： Yoshida, Junya ,  Kanehara, Hideyuki ,  Ujihara, Dai ,  Inazawa, Johji ,  Imoto, Issei

IPC分类号： G06F19/20 ,  C12Q1/68

CPC分类号： G06F19/20 ,  C12Q1/6837 ,  C12Q2525/161 ,  C12Q2545/101

公开(公告)号：EP3040049A1

公开(公告)日：2016-07-06

申请号：EP14840885.9

申请日：2014-08-29

申请人： National University Corporation Tokyo Medical and Dental University

发明人： YOSHITAKE, Hiroyuki

IPC分类号： A61C19/045 ,  A61B5/11 ,  G01B3/04

CPC分类号： G01B3/04 ,  A61B5/1071 ,  A61C19/045 ,  G01B3/50

摘要： Provided is an opening measurement instrument which exhibits excellent instrument stability during measurement, and excellent measurement accuracy and reproducibility thereof. This opening measurement instrument is provided with: an engagement part which measures an opening amount between an upper jaw and a lower jaw, and which engages with first reference teeth in one of the jaws; a measurement surface which, while the engagement part is in a state of being engaged with the first reference teeth, is brought into contact with second reference teeth in the other jaw; and a first scale which is provided to the measurement surface, and which indicates the distance from the engagement part. The opening measurement instrument is preferably further provided with a second scale which is provided to the measurement surface, and which indicates the position of a direction orthogonal to the direction in which the first scale is provided. The measurement surface is preferably configured from a curved surface in which the measurement surface between the engagement part and a prescribed point of the measurement surface bulges with respect to a flat surface connecting the engagement part and the prescribed point of the measurement surface. Furthermore, the curved surface is preferably provided with a section having a curvature which increases as the distance from the engagement part increases.

摘要翻译： 提供了一种在测量期间显示出优异的仪器稳定性并且具有优异的测量精度和重现性的开口测量仪器。 该开口测量仪器设有：测量上钳口和下钳口之间的开口量并且与其中一个夹爪中的第一参考齿接合的接合部分; 当接合部处于与第一参考齿接合的状态下的测量表面与另一个夹爪中的第二参考齿接触; 以及设置在测量面上并且表示与接合部的距离的第一刻度。 开口测量仪器优选地还设置有设置到测量表面的第二刻度，并且其指示与设置第一刻度尺的方向正交的方向的位置。 测量表面优选地由弯曲表面构成，其中接合部分和测量表面的规定点之间的测量表面相对于连接接合部分和测量表面的规定点的平坦表面凸出。 此外，弯曲表面优选地设置有随着距接合部的距离增加而增加的曲率的部分。

公开(公告)号：EP2891456A1

公开(公告)日：2015-07-08

申请号：EP13832370.4

申请日：2013-08-30

申请人： National University Corporation Tokyo Medical and Dental University ,  Riken

发明人： ISHIKAWA, Kinya ,  MIZUSAWA, Hidehiro ,  NAGAO, Soichi ,  HONDA, Takeru ,  HASHIMOTO, Yuji

IPC分类号： A61B10/00 ,  A61B5/11

CPC分类号： A61B5/4082 ,  A61B5/1124 ,  A61B5/4064 ,  A61B5/4088 ,  A61B5/742 ,  A61B5/7475 ,  G02B27/2242 ,  G06F3/0412

摘要： In order to evaluate a motor-function disorder accompanying a brain disease by a non-conventional new method, a brain function evaluation system 1 is provided with: a display device 11 for displaying a mark indicated by a subject X; an indicated position identification unit 14 for identifying an indicated position on the display device 11 indicated by the subject X; and a divergence quantity calculation unit 16 for calculating a divergence quantity between a display position of the mark and the indicated position indicated by the subject X.

摘要翻译： 为了通过非常规的新方法评估伴随脑疾病的运动功能障碍，脑功能评估系统1具有：显示装置11，用于显示被检体X所指示的标记; 用于识别由被摄体X指示的显示装置11上的指示位置的指示位置识别单元14; 以及分散量计算单元16，用于计算标记的显示位置和由被摄体X指示的指示位置之间的发散量。