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公开(公告)号：EP0612521A1
公开(公告)日：1994-08-31
申请号：EP92922993.8
申请日：1992-11-06
发明人： NODA, Kanji, Hisamitsu Pharmaceutical Co., Inc. , SAITA, Masaru, Hisamitsu Pharmaceutical Co., Inc. , HIRANO, Munehiko, Hisamitsu , IKEURA, Yasuhiro, Hisamitsu , TANIGUCHI, Yasuaki, Hisamitsu , HASHIGUCHI, Terushi, Hisamitsu , KOSE, Yasuhisa, Hisamitsu Pharmaceutical Co., Inc. , TAKADA, Yasunori, Hisamitsu , KYOYA, Eigi, Hisamitsu Pharmaceutical Co., Inc. , NAKAGAWA, Akira, Hisamitsu
CPC分类号： A61K9/7061 , A61K31/40
摘要： A fomentation containing ketorolac, one of nonsteroidal anti-inflammatory analgesics, or a salt thereof as an active ingredient, a water-soluble high-molecular compound as a base ingredient, a humectant, water, and optionally an absorption promoter.
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公开(公告)号：EP0592664A1
公开(公告)日：1994-04-20
申请号：EP91905483.3
申请日：1991-03-07
发明人： SAITA, Masaru, 855-75, Kokura , INOUE, Hisataka, 1473-10, Tsubukuhonmachi , IKESUE, Kouichi, 193-1, Yamaryo Morodomimachi , FUJIMOTO, Noriyuki, 1175-3, Sakuramachi , SHINOHARA, Ikuo, 786-1, Tashirodaikanmachi , TANIGUCHI, Yasuaki, 567-1, Tashirohokamachi , DEGUCHI, Yoshiki, 1175-3, Sakuramachi , MINAMI, Hidenao, 1032-3, Ooazafutsukaichi , NODA, Kanji, 320-93, Ooazatsunematsu
IPC分类号： C07D277/44 , C07D277/52 , C07D277/46
CPC分类号： C07D277/46 , C07D277/52
摘要： A novel diphenylthiazole derivative which is effectively used as a medicine with an anti-inflammaory, analgesic, antiallergic, uric acid excretion stimulating, or platelet aggregation inhibiting action and is represented by general formula (I), wherein m and n are each 1 or 2; R¹ and R² each represents hydrogen, lower alkyl, lower alkoxy, lower alkylsulfonyl, nitro, amino, methanesulfonyloxy, or halogen; A¹ represents lower alkanesulfonyl, halogenated lower alkanesulfonyl, substituted bezenesulfonyl, lower acyl, or halogenated lower acyl; and A² represents hydrogen, lower alkanesulfonyl, halogenated lower alkanesulfonyl, or lower alkyl.
摘要翻译： 一种新的二苯基噻唑衍生物，其有效地用作具有抗炎，镇痛，抗过敏，尿酸排泄刺激或血小板聚集抑制作用的药物，并且由通式（I）表示，其中m和n各自为1或2 ; R 1和R 2各代表氢，低级烷基，低级烷氧基，低级烷基磺酰基，硝基，氨基，甲磺酰氧基或卤素; A 1代表低级链烷磺酰基，卤代低级链烷磺酰基，取代的苯磺酰基，低级酰基或卤代低级酰基; A 2代表氢，低级链烷磺酰基，卤代低级链烷磺酰基或低级烷基。
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公开(公告)号：EP0571712A3
公开(公告)日：1994-02-23
申请号：EP93101994.7
申请日：1993-02-09
发明人： Okabe, Keiichiro
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61N1/0436 , A61N1/0444 , A61N1/0448
摘要： An interface composed of an aqueous solution (2) supply portion capable of providing a fine hole (7) for supplying an aqueous solution (2), a water-permeable electrode (3), and a water-absorbable or water-permeable film-like membrane (5), laminated integrally, wherein the fine hole (7) for supplying the solution (2) is made in the aqueous solution supply portion at the time of use, the aqueous solution (2) is supplied through the water-permeable electrode (3) and water-absorbable or water-permeable film-like membrane (5), and, when the aqueous solution (2) reaches them, the drug or the drug-containing water-soluble layer dissolve and a locally high concentration solution of the drug is formed.
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公开(公告)号：EP0471618B1
公开(公告)日：1993-09-29
申请号：EP91402231.4
申请日：1991-08-12
发明人： Yamamoto, Nakayuki , Sugimoto, Michihiko , Sakakibara, Hideo , Saita, Masaru , Shimozono, Yuji , Manako, Takafumi
CPC分类号： A61K38/23 , A61K9/0043 , A61K9/1075 , A61K47/22 , Y10S514/808
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115.发明授权Azacycloalkane derivatives, absorption promoters containing the derivatives as the effective ingredient and external preparation containing the absorption promoters 失效亚胺卡因衍生物，含有衍生物的吸收促进剂作为有效成分和包含吸收促进剂的外部制剂
公开(公告)号：EP0241050B1
公开(公告)日：1992-10-14
申请号：EP87200183.9
申请日：1987-02-07
发明人： Tsuji, Masayoshi , Inoue, Hisataka , Hachiya, Terumi , Nakashima, Mikio , Saita, Masaru , Shimozono, Yuji , Nakagawa, Akira , Sakai, Michinori
IPC分类号： C07D207/27 , C07D211/76 , C07D223/10 , C07D263/18 , C07D265/30 , C07D267/10 , C07D277/14 , C07D279/12 , C07D281/06 , A61K47/00 , A01N25/32
CPC分类号： C07D207/267 , C07D207/27 , C07D211/76 , C07D223/10 , C07D263/18 , C07D265/32 , C07D277/14 , C07D279/12 , C07D281/06 , Y10S514/946
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116.发明公开Low frequency curing apparatus applicable directly to organism 失效Niederfrequenz-Heilapparat zur direkten Anwendung auf dem有机体。
公开(公告)号：EP0290126A2
公开(公告)日：1988-11-09
申请号：EP88302571.0
申请日：1988-03-23
CPC分类号： A61N1/36014 , A61N1/025 , A61N1/0492 , A61N1/322 , A61N1/378
摘要： A low frequency curing apparatus includes a power source (11, 21, 21a, 111, 151); a boosted pulse generating unit (12; 23, 25; 113, 114; 153, 154) for generating a train of boosted pulses in response to a first pulse signal (C1, S1, S11, S21); an accumulating unit (13; 26; 116, 123; 156) for accumulating the boosted pulses to a predetermined amount; a low frequency pulse outputting unit (14; 27; 117, 120, 126; 157 - 160) for outputting the accumulated boosted pulses as low frequency pulses in response to a second pulse signal (C2; S2; S12; S22, S23); a pair of electrode members (K, F) able to be applied in a plane state to an object to be stimulated, for transmitting the low frequency pulses to the object; and a signal processing unit (15; 22; 22a, 22b; 22c; 112; 152) for outputting the first and second pulse signals based on a predetermined algorithm.
A pulse width or a pulse interval of the first pulse signal or second pulse signal is changed, and as a result, a variety of low frequency stimulation effects can be applied to the object to be stimulated.摘要翻译： 低频固化装置包括电源（11,21,21a，111,151）。 用于响应于第一脉冲信号（C1，S1，S11，S21）产生升压脉冲序列的升压脉冲发生单元（12; 23,25; 113,114; 153,154）。 用于将升压脉冲累积到预定量的累积单元（13; 26; 116,123; 156） 用于响应于第二脉冲信号（C2; S2; S12; S22，S23）将累积升压脉冲作为低频脉冲输出的低频脉冲输出单元（14; 27; 117,120,126; 157-160） 能够以平面状态施加到要被刺激的物体的一对电极构件（K，F），用于将低频脉冲发送到物体; 以及用于基于预定算法输出第一和第二脉冲信号的信号处理单元（15; 22; 22a，22b; 22c; 112; 152）。 第一脉冲信号或第二脉冲信号的脉冲宽度或脉冲间隔被改变，结果可以对被刺激对象施加各种低频刺激效果。
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117.发明公开Azacycloalkane derivatives, absorption promoters containing the derivatives as the effective ingredient and external preparation containing the absorption promoters 失效氮杂环烷烃衍生物，含有所述衍生物作为有效成分的吸收促进剂包括外用制剂，吸收促进剂。
公开(公告)号：EP0241050A2
公开(公告)日：1987-10-14
申请号：EP87200183.9
申请日：1987-02-07
发明人： Tsuji, Masayoshi , Inoue, Hisataka , Hachiya, Terumi , Nakashima, Mikio , Saita, Masaru , Shimozono, Yuji , Nakagawa, Akira , Sakai, Michinori
IPC分类号： C07D207/27 , C07D211/76 , C07D223/10 , C07D263/18 , C07D265/30 , C07D267/10 , C07D277/14 , C07D279/12 , C07D281/06 , A61K47/00 , A01N25/32
CPC分类号： C07D207/267 , C07D207/27 , C07D211/76 , C07D223/10 , C07D263/18 , C07D265/32 , C07D277/14 , C07D279/12 , C07D281/06 , Y10S514/946
摘要： An azacycloalkane derivative useful for promoting the absorption of a medicine, an absorption promoting agent comprising at least one of the azacycloalkane derivatives as the effective ingredient for promoting the absorption and an external preparation containing the absorption promoting agent, the derivative being represented by the following formula
wherein A is -CH 2 -or -S-for example, B is sulfur or oxygen, R is -SR" in which R" is an alkyl group or alkylthioalkyl group for example, or -OR" in which R" is as defined above, an alkyl group or substituted amino group, R' is a hydrogen atom, alkyl group or alkyloxy group for example, m is an integer of 0-5 and n is an integer of 1-15.摘要翻译： 在氮杂环烷烃衍生物可用于促销婷药物的吸收宣传片婷剂吸收包含的氮杂环烷烃衍生物作为促销婷吸收和外用制剂含有上述吸收宣传片婷剂的有效成分中的至少一个，所述衍生物是由下式表示
worin A是-CH 2 - 或-S-实施例，B是硫或氧，R是-SR“”，其中R“”是其中的烷基或烷硫基烷基，例如，或或“” R“”是如上所定义，以烷基或substituiertem氨基，R“是氢原子，烷基或烷氧基，例如，m是0-5的整数，n是1-15的整数。 -
公开(公告)号：EP0047674A1
公开(公告)日：1982-03-17
申请号：EP81304119.1
申请日：1981-09-09
IPC分类号： C07D209/46
CPC分类号： C07D209/46
摘要： A process for the preparation of an isoindolin derivative comprising cyclizing a benzylidene derivative in the presence of a reducing agent such as sodium boron hydride. In one embodiment, the benzylidene derivative may be substituted by a reaction mixture containing the same, the reaction mixture being prepared by reacting o-phthalaldehydic acid or its ester with an aniline derivative.
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公开(公告)号：EP4410282A1
公开(公告)日：2024-08-07
申请号：EP22889923.3
申请日：2022-10-31
摘要： An adhesive patch with a cover material includes an adhesive patch part including a backing and a drug layer formed on the backing; and a cover part including a cover layer and a cover adhesive layer formed on the cover layer, and the cover adhesive layer is attached to the backing to cover the adhesive patch part. The cover layer is formed of a non-woven fabric, and has an elongation rate of 50% to 300% in a flow direction and a width direction. The cover adhesive layer is made of a rubber-based adhesive in which a main adhesive base is a rubber-based adhesive base, and has a loss tangent (tanδ) of 0.7 to 0.95 at 32°C and 0.1 Hz.
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120.发明公开
公开(公告)号：EP4299130A1
公开(公告)日：2024-01-03
申请号：EP22759516.2
申请日：2022-02-18
摘要： A diclofenac-containing patch package product, in which a diclofenac-containing patch, including an adhesive layer containing diclofenac sodium as a drug and dimethyl sulfoxide as a solvent, and a backing layer, is sealed in a packaging bag,
the packaging bag being formed of a laminate at least comprising:
an innermost layer composed of at least one selected from the group consisting of polyethylene terephthalate and cycloolefin polymer;
an oxygen barrier layer arranged outside the innermost layer; and
an outer layer arranged outside the oxygen barrier layer.
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