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2452 条记录 (耗时 0.061 秒)

    K-RAS MUTATIONS AND ANTI-EGFR ANTIBODY THERAPY
    114.
    发明授权
    K-RAS MUTATIONS AND ANTI-EGFR ANTIBODY THERAPY 有权
    K-RAS突变和抗EGFR抗体治疗

    公开(公告)号：EP2465950B1

    公开(公告)日：2017-07-12

    申请号：EP12154109.8

    申请日：2008-03-11

    申请人： Amgen Inc.

    发明人： FREEMAN, Daniel ,  JUAN, Todd ,  RADINSKY, Robert

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/118

    摘要： The present application relates to K-ras mutations, to polynucleotides encoding mutant K-ras polypeptides, and to methods of identifying K-ras mutations. The present application also relates to methods of diagnosing cancer; and methods and kits for predicting the usefulness of anti-EGFr specific binding agents in the treatment of tumors.

    摘要翻译： 本申请涉及K-ras突变，编码突变K-ras多肽的多核苷酸，以及鉴定K-ras突变的方法。 本申请还涉及诊断癌症的方法; 以及用于预测抗EGFr特异性结合剂在肿瘤治疗中的有用性的方法和试剂盒。

    AUTOINJECTOR WITH LOW ENERGY PLUNGER LOADING
    115.
    发明公开
    AUTOINJECTOR WITH LOW ENERGY PLUNGER LOADING 审中-公开
    具有低能量柱塞装载的自动注射器

    公开(公告)号：EP3164175A1

    公开(公告)日：2017-05-10

    申请号：EP15734035.7

    申请日：2015-06-26

    申请人： Amgen Inc.

    发明人： FOLK, Christopher R. ,  GIBSON, Scott R. ,  INTOCCIA, Brian J.

    IPC分类号： A61M5/20 ,  A61M5/31

    CPC分类号： A61M5/20 ,  A61M5/31571 ,  A61M5/31576 ,  A61M5/3245 ,  A61M2005/2013 ,  A61M2005/3143

    摘要： An injection device, method, and system for drug delivery includes a container for storing a drug, the container having a stopper movably disposed in the container for expelling the drug; an injection drive mechanism having a plunger for acting on the stopper and an energy source having a first selected potential energy for exerting a force on the plunger to cause the plunger to act on the stopper to expel the drug; and a plunger loading mechanism for substantially preventing the plunger from accelerating to a predetermined velocity before it acts on the stopper. The plunger loading mechanism may be a spring having a second selected potential energy for reducing or eliminating a distance between the plunger and the stopper, prior to the plunger accelerating to the velocity. The second selected potential energy of the spring may be less than the first selected potential energy of the energy source.

    摘要翻译： 用于药物输送的注射装置，方法和系统包括用于储存药物的容器，容器具有可移动地设置在容器中用于排出药物的塞子; 注射驱动机构，所述注射驱动机构具有用于作用在所述塞子上的柱塞和具有第一选择势能的能量源，用于在所述柱塞上施加力以使所述柱塞作用在所述塞子上以排出所述药物; 以及柱塞加载机构，用于基本上防止柱塞在其作用在挡块上之前加速到预定速度。 柱塞加载机构可以是具有第二选定势能的弹簧，用于在柱塞加速到速度之前减小或消除柱塞与止动器之间的距离。 弹簧的第二选择势能可以小于能量源的第一选择势能。

    ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF
    120.
    发明公开
    ANTI-ACTIVIN A ANTIBODIES AND USES THEREOF 审中-公开
    安东尼奥GEGEN ACTIVIN A UND VERWENDUNGEN DAVON

    公开(公告)号：EP3133084A1

    公开(公告)日：2017-02-22

    申请号：EP16178026.7

    申请日：2007-09-07

    申请人： Amgen Inc.

    发明人： HAN, Hq ,  CHEN, Qing ,  KWAK, Keith Soo-Nyung ,  ZHOU, Xiaolan

    IPC分类号： C07K16/22 ,  A61K39/395 ,  C12N15/13 ,  A61P5/06 ,  A61P9/10 ,  A61P35/00 ,  A61P37/00 ,  A61P43/00

    摘要： The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

    摘要翻译： 本公开提供与抗激活素A结合蛋白（包括抗体）相关或衍生的组合物和方法。 在具体实施方案中，本公开提供了完全人，人源化和嵌合的抗激活素A抗体，其结合人激活素A，激活素A结合片段和此类抗体的衍生物，以及包含此类片段的激活素A-结合多肽。 其他实施方案提供编码此类抗体，抗体片段和衍生物和多肽的核酸，包含此类多核苷酸的细胞，制备此类抗体的方法，抗体片段和衍生物和多肽，以及使用此类抗体，抗体片段和衍生物和多肽的方法，包括方法 治疗或诊断具有激活素A相关疾病或包括与性腺癌，其他癌症，类风湿性关节炎和其他疾病相关的恶病质的病症的受试者。