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公开(公告)号：EP3005995A1
公开(公告)日：2016-04-13
申请号：EP14804437.3
申请日：2014-05-29
摘要： The object of the present invention is to provide an annular device superior to a conventional annular device in the stability over an eyeball when being worn, which overcomes problems caused by wearing a conventional annular device.
The above object is attained by preparing an annular device to be worn over the surface of the sclera, the annular device including an opening exposing the cornea and one or a plurality of approximately encircling grooves on an intermediate part between an inner rim part and an outer rim part. The annular device has a maximum thickness preferably in the intermediate part.-
公开(公告)号：EP2952190A1
公开(公告)日：2015-12-09
申请号：EP14745605.7
申请日：2014-01-30
发明人： SHIKAMURA, Yuko , HIGASHIMURA, Yuka
IPC分类号： A61K31/427 , A61K9/08 , A61K47/10 , A61K47/34 , A61P27/02
CPC分类号： A61K47/10 , A61K9/0048 , A61K9/08 , A61K31/427
摘要： The present invention provides an aqueous liquid preparation having high stability to light and heat, which contains (3-{2-[4-isopropyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]ethyl}-5-methyl-1,2-benzisoxazol-6-yl)oxyacetic acid or a pharmaceutically acceptable salt thereof, and tyloxapol or octoxynol.
摘要翻译： 本发明提供对光和热具有高稳定性的含水液体制剂，其含有（3- {2- [4-异丙基-2-（4-三氟甲基）苯基-5-噻唑基]乙基} -5-甲基-1 ，2-苯并异恶唑-6-基）氧基乙酸或其药学上可接受的盐，以及泰洛沙泊或辛辛醇。
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公开(公告)号：EP2423124A1
公开(公告)日：2012-02-29
申请号：EP10767038.2
申请日：2010-04-19
发明人： OTSUKA Tadashi , FUJIMOTO Takashi
CPC分类号： B65D81/3211 , A61F9/0008 , A61J1/1418 , A61J1/2031 , A61J1/2093 , B65D47/06 , B65D51/2892
摘要： The present invention provides a before-use mixing container in which it is possible to perform a mixing operation for two types of medicinal solutions in its container independently of an uncovering operation for a cap or the like.
The before-use mixing container including a movable body 1 which has a tube section 11, a ceiled cylindrical inner tube 13 which is consecutively installed upright on an inner surface of the tube section, that partitions the tube section into two upper and lower chambers, and a first opening portion 13b drilled in a ceiling plane 13a of the inner tube, and in which a first medicinal solution A is contained in the lower chamber, an adapter 3 which has a fit-in tube section 31 which is tightly fit into the upper chamber of the movable body to be assembled so as to be rotatable with respect to the movable body, a partition wall surface 35 which is provided on an inner surface of the fit-in tube section, and is tightly attached to the ceiling plane of the inner tube of the movable body, and a second opening portion 35a which is drilled in the partition wall surface so as not to overlap the first opening portion, and a container main body 4 which has a lower mouth tube section 42 tightly fit into the upper chamber of the adapter, to be assembled so as not to be rotatable with respect to the adapter, and in which a second medicinal solution B is contained, in the before-use mixing container, when the movable body is relatively rotated with respect to the container main body, the first opening portion and the second opening portion are overlapped.摘要翻译： 本发明提供了一种使用前混合容器，其中可以独立于帽等的露出操作，在其容器中对两种类型的药液进行混合操作。 该使用前混合容器包括具有管部11的可移动体1，在管部的内表面上直立地连续安装的细长圆柱形内管13，其将管部分分成两个上下腔室， 以及在内管的顶板13a中钻出的第一开口部分13b，其中第一药液A容纳在下腔室中，适配器3具有紧密地配合在内管中的配合管部31 可移动体的上部腔室可相对于可移动体旋转，分隔壁表面35设置在装配管部分的内表面上，并且紧密地附接到 可移动体的内管和在隔壁表面上不与第一开口部分重叠的第二开口部分35a，以及容器主体4，该主体4具有下端口部分42， 进入适配器的上部腔室，以便相对于适配器不能旋转，并且其中容纳第二药液B，在使用前混合容器中，当可移动体相对旋转时 相对于容器主体，第一开口部和第二开口部重叠。
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公开(公告)号：EP2397114A1
公开(公告)日：2011-12-21
申请号：EP09840054.2
申请日：2009-12-25
IPC分类号： A61F9/007
CPC分类号： A61F9/04 , A61F9/0017 , G02C7/04
摘要： The present invention aims to provide a ring-shaped device superior in the wearing comfort and intraocular stability while being worn on the eye.
Provided is a ring-shaped device to be worn on the scleral surface, which is characterized in that it has an opening to expose the cornea and an intermediate portion between an inner edge portion and an outer edge portion has a maximum thickness.摘要翻译： 本发明旨在提供一种佩戴在眼睛上时佩戴舒适性和眼内稳定性优异的环状装置。 提供一种要在巩膜表面上佩戴的环形装置，其特征在于，其具有露出角膜的开口，并且内边缘部分和外边缘部分之间的中间部分具有最大厚度。
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公开(公告)号：EP1459743B1
公开(公告)日：2011-10-19
申请号：EP04014078.2
申请日：1999-08-13
IPC分类号： A61K31/00 , A61K31/437 , A61K31/4409 , A61K31/4545 , A61K31/496 , A61K31/551 , A61P27/06
CPC分类号： A61K31/551 , A61K31/00 , A61K31/437 , A61K31/4409 , A61K31/4545 , A61K31/496 , Y10S514/912 , Y10S514/913
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公开(公告)号：EP1459742B1
公开(公告)日：2011-10-12
申请号：EP04014077.4
申请日：1999-08-13
IPC分类号： A61K31/00 , A61K31/437 , A61K31/4409 , A61K31/4545 , A61K31/496 , A61K31/551 , A61P27/02 , A61P27/10
CPC分类号： A61K31/551 , A61K31/00 , A61K31/437 , A61K31/4409 , A61K31/4545 , A61K31/496 , Y10S514/912 , Y10S514/913
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公开(公告)号：EP1364660B1
公开(公告)日：2010-12-22
申请号：EP02700689.9
申请日：2002-02-21
发明人： TOJO, Kakuji , FUJIKAWA, Yoshiko
IPC分类号： A61K47/34 , A61K9/00 , A61K9/14 , A61K45/00 , A61K39/00 , A61P31/04 , A61P31/12 , A61P9/00 , A61P27/06 , A61P27/02 , A61P35/00
CPC分类号： A61K47/34 , A61K9/0024 , A61K9/204 , A61K9/2095
摘要： A method for producing compression-melt molded product using polylactic acid powder is described. The method comprises the steps of: 1) heat-melting polylactic acid having a weight-average molecular weight of 3,000-40,000 at 140-220 DEG C, 2) allowing the melted polylactic acid to cool down to solidify at an ordinary or a lower temperature, 3) pulverizing the solidified polylactic acid at an ordinary temperature into powder, and 4) compressing the powder or a mixture powder prepared by addition of another ingredient, e.g., a biologically active compound, to the carrier powder in a mold at an ordinary temperature to cause the polylactic acid to melt into a molded product of a predetermined shape.
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118.发明公开PHARMACEUTICAL CONTAINING HIF-1 ALPHA AND HIF-2 ALPHA EXPRESSION INHIBITOR 有权ARZNEIMITTEL MIT HIF-1-ALPHA-和HIF-2-ALPHA-EXPRESSIONSHEMMER
公开(公告)号：EP2186528A1
公开(公告)日：2010-05-19
申请号：EP08827097.0
申请日：2008-08-05
IPC分类号： A61K45/00 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K35/76 , A61K48/00 , A61P3/10 , A61P27/02 , A61P37/06 , A61P43/00 , C12N15/00
CPC分类号： A61K45/06 , A61K31/7088 , A61K31/7105 , A61K31/713 , C12N15/113 , C12N15/1136 , C12N2310/11 , C12N2310/14
摘要： Provided is a pharmaceutical product exhibiting a high therapeutic effect in the treatment of retinal diseases associated with angiogenesis such as age-related macular degeneration, diabetic retinopathy and the like. A therapeutic agent for a retinal disease, containing a substance specifically inhibiting HIF-1α expression and a substance specifically inhibiting HIF-2α expression. The aforementioned inhibitory substances, which are active ingredients in the therapeutic agent of the present invention, are nucleic acids capable of inducing RNAi, antisense nucleic acids or ribozymes for HIF-1α and HIF-2α, or expression vectors thereof.
摘要翻译： 本发明提供了治疗与血管生成相关的视网膜疾病如老年性黄斑变性，糖尿病性视网膜病变等的治疗效果高的药物。 一种视网膜疾病的治疗剂，其含有特异性抑制HIF-1±表达的物质和特异性抑制HIF-2±表达的物质。 作为本发明的治疗剂中的活性成分的上述抑制物质是能够诱导HIF-1±和HIF-2±的RNAi，反义核酸或核酶或其表达载体的核酸。
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119.发明公开SUSPENSION FOR VISUALIZATION OF TRANSPARENT TISSUE IN EYE 审中-公开悬挂ZUR VISUALISIERUNG VON TRANSPARENTEN AUGENGEWEBEN
公开(公告)号：EP2140871A1
公开(公告)日：2010-01-06
申请号：EP08739562.0
申请日：2008-04-01
发明人： MATSUHISA, Keiichi
CPC分类号： A61K31/765 , A61K9/0048 , A61K9/1647 , A61K49/0091
摘要： Disclosed is an ocular transparent tissue-visualizing suspension which can be used as an easy-to-handle and sufficiently safe means to enhance visibility of transparent tissues of the eye during a surgical operation on them. The ocular transparent tissue-visualizing suspension comprises, in an aqueous medium, fine particles of a biodegradable macromolecular compound and at least one salt selected from the groups consisting of salts of trivalent metals and salts of divalent metals.
摘要翻译： 公开了一种眼部透明组织可视化悬浮液，其可以用作易于处理和足够安全的手段，以在其手术操作期间增强眼睛的透明组织的可视性。 眼睛透明组织可视化悬浮液在水性介质中包含生物降解性高分子化合物的细颗粒和选自三价金属盐和二价金属盐的至少一种盐。
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120.发明公开AQUEOUS LIQUID PREPARATION COMPRISING GATIFLOXACIN 审中-公开GATIFLOXACIN ENTHALTENDEWÄSSRIGEFLÜSSIGEZUBEREITUNG
公开(公告)号：EP2078527A1
公开(公告)日：2009-07-15
申请号：EP07829585.4
申请日：2007-10-11
发明人： SAWA, Shirou
CPC分类号： A61K31/496 , A61K9/0048 , A61K9/08 , A61K47/10 , A61K47/36
摘要： Disclosed is an aqueous liquid preparation comprising (A) gatifloxacin, a pharmacologically acceptable salt thereof or a hydrate gatifloxacin or the salt, (B) hyaluronic acid or a pharmacologically acceptable salt thereof, and (C) a polyhydric alcohol. The aqueous liquid preparation is an ophthalmic aqueous liquid preparation excellent in the retention of gatifloxacin in a tear fluid and the penetration of gatifloxacin into an aqueous humor and a conjunctiva.
摘要翻译： 本发明公开了含有（A）加替沙星，其药理学上可接受的盐或加替沙星或其盐，（B）透明质酸或其药学上可接受的盐和（C）多元醇的含水液体制剂。 含水液体制剂是眼用水性液体制剂，其优点在于加替沙星在泪液中的保留以及加替沙星渗入房水和结膜中。
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