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1.发明授权
公开(公告)号：EP0995435B1
公开(公告)日：2007-04-25
申请号：EP98917756.3
申请日：1998-04-30
CPC分类号： A61K9/0019 , A61K9/0014 , A61K9/0043 , A61K9/0048 , A61K9/08 , A61K47/32 , A61K47/38 , Y10S514/846 , Y10S514/912 , Y10S514/914 , Y10S514/937
摘要： A aqueous suspension preparations of hardly soluble drugs containing water soluble polymers at a concentration within a range from the concentration at which the decrease in the surface tension of the liquid preparations is initiated to the concentration at which such decrease is terminated. These preparations can be easily redispersed and undergo neither aggregation of the dispersed particles nor caking. The excellent redispersibility of these preparations makes them useful as injections, eye drops, nasal drops, drugs for internal use, lotions, etc.
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2.发明公开AQUEOUS SUSPENSION PREPARATIONS WITH EXCELLENT REDISPERSIBILITY 失效WÄSSRIGESUSPENSIONSPRÄPARATIONENMIT EXZELLENTERREDISPERSIBILITÄT
公开(公告)号：EP0995435A1
公开(公告)日：2000-04-26
申请号：EP98917756.3
申请日：1998-04-30
CPC分类号： A61K9/0019 , A61K9/0014 , A61K9/0043 , A61K9/0048 , A61K9/08 , A61K47/32 , A61K47/38 , Y10S514/846 , Y10S514/912 , Y10S514/914 , Y10S514/937
摘要： The aqueous suspension can be prepared by incorporating, in an aqueous suspension of a hardly soluble drug, a water-soluble polymer within the concentration range from the concentration at which the surface tension of the aqueous suspension of the drug begins to decrease up to the concentration at which the reduction in surface tension ceases. The resulting aqueous suspension shows ready redispersibility and will not undergo aggregation of dispersed particles or caking. Because of its good redispersibility, the suspension is useful as a parenteral preparation, eye drops, nasal drops, a preparation for oral administration, a lotion or the like.
摘要翻译： 含水悬浮液可以通过在难溶性药物的水性悬浮液中掺入水溶性聚合物来制备，所述水溶性聚合物的浓度范围是从药物的水性悬浮液的表面张力开始降低至浓度的浓度 表面张力下降停止。 所得水性悬浮液显示出可再分散性，并且不会发生分散的颗粒或结块的聚集。 由于其良好的再分散性，悬浮液可用作肠胃外制剂，滴眼剂，滴鼻剂，口服制剂，洗剂等。
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3.发明公开SUSPENSION FOR VISUALIZATION OF TRANSPARENT TISSUE IN EYE 审中-公开悬挂ZUR VISUALISIERUNG VON TRANSPARENTEN AUGENGEWEBEN
公开(公告)号：EP2140871A1
公开(公告)日：2010-01-06
申请号：EP08739562.0
申请日：2008-04-01
发明人： MATSUHISA, Keiichi
CPC分类号： A61K31/765 , A61K9/0048 , A61K9/1647 , A61K49/0091
摘要： Disclosed is an ocular transparent tissue-visualizing suspension which can be used as an easy-to-handle and sufficiently safe means to enhance visibility of transparent tissues of the eye during a surgical operation on them. The ocular transparent tissue-visualizing suspension comprises, in an aqueous medium, fine particles of a biodegradable macromolecular compound and at least one salt selected from the groups consisting of salts of trivalent metals and salts of divalent metals.
摘要翻译： 公开了一种眼部透明组织可视化悬浮液，其可以用作易于处理和足够安全的手段，以在其手术操作期间增强眼睛的透明组织的可视性。 眼睛透明组织可视化悬浮液在水性介质中包含生物降解性高分子化合物的细颗粒和选自三价金属盐和二价金属盐的至少一种盐。
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4.发明公开
公开(公告)号：EP1752152A1
公开(公告)日：2007-02-14
申请号：EP05743700.6
申请日：2005-05-30
发明人： MATSUHISA, Keiichi , INOUE, Yutaka
IPC分类号： A61K31/718 , A61K31/722 , A61K31/765 , A61K45/00 , A61P27/02 , A61P27/12
CPC分类号： A61K31/718 , A61K9/0048 , A61K31/722 , A61K31/765 , A61K49/0091 , A61K2300/00
摘要： Described is a highly safe means to improve visibility of transparent tissues of the eye, i.e., the vitreous body, the lens or the cornea, in a surgical operation on them. The means comprises fine particles of a macromolecular compound, in particular, those one gram of which cannot be dissolved in less than 30 mL of water within 30 minutes at 20 °C, and whose average particle size is 0.01-500 µm, and which, among others, is a biodegradable macromolecular compound and/or a water soluble macromolecular compound.
摘要翻译： 描述的是在其外科手术中改善眼睛的透明组织，即玻璃体，晶状体或角膜的可视性的高度安全的手段。 该方法包括高分子化合物的细颗粒，特别是在20℃下在30分钟内不能溶解在少于30mL水中的那些1g，平均粒径为0.01-500μm， 是一种可生物降解的高分子化合物和/或水溶性大分子化合物。
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