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142 条记录 (耗时 0.021 秒)

    PAPAVER BRACTEATUM WITH MODIFIED ALKALOID CONTENT
    111.
    发明公开
    PAPAVER BRACTEATUM WITH MODIFIED ALKALOID CONTENT 审中-公开
    与改性生物碱ARMENIAN POPPY

    公开(公告)号：EP2635107A1

    公开(公告)日：2013-09-11

    申请号：EP11837323.2

    申请日：2011-10-31

    申请人： TPI Enterprises Ltd.

    发明人： COOMBS, Justin, Taylor ,  RITCHIE, Jarrod, David ,  TESTER, Mark, Alfred ,  LIGHTFOOT, Damien ,  JHA, Deepa

    IPC分类号： A01H5/08 ,  C07D221/28 ,  C12N15/53 ,  A01H5/10 ,  C07D489/02

    CPC分类号： C12N9/0006 ,  C07D489/02 ,  C12N9/0004 ,  C12N9/0071 ,  C12N15/8243 ,  C12P17/18 ,  C12Y101/01247 ,  C12Y114/11031 ,  C12Y114/11032

    摘要： The present invention relates to genetically modified plants of the species Papaver bracteatum wherein the type or amount of one or more alkaloids produced by the plants has been modified. Specifically, the genetically modified plants have an increased expression of one or more of thebaine 6-O-demethylase, codeine O- demethylase and/or codeinone reductase relative to wild type P. bracteatum such that the genetically modified poppy plants produce an increased quantity of an alkaloid selected from codeine, oripavine and/or morphine relative to a wild type P. bracteatum. Also provided are progeny plants having the genetically modified poppy plants described above as a parent; mutant or derivative plants of the aforementioned plants; reproductive material derived from, straw produced from, straw concentrate produced from, latex derived from, or one or more isolated cells derived from, the aforementioned plants. Methods for producing an alkaloid from the aforementioned plants are also provided, together with nucleic acid and amino acid sequence variants of the 6-O-demethylase and codeine O-demethylase genes.

    PROCESS FOR PREPARING HYDROCODONE USING A SUPER ACID
    112.
    发明公开
    PROCESS FOR PREPARING HYDROCODONE USING A SUPER ACID 有权
    用于生产氢可酮使用超酸

    公开(公告)号：EP2393783A1

    公开(公告)日：2011-12-14

    申请号：EP09760689.1

    申请日：2009-11-30

    申请人： Mallinckrodt LLC

    发明人： WANG, Peter, X. ,  JIANG, Tao ,  LIAO, Subo ,  MOORE, Erin

    IPC分类号： C07D221/28 ,  C07D489/02

    CPC分类号： C07D489/02 ,  C07D221/28

    摘要： The present disclosure generally relates to a process for converting a fused, tricyclic compound to a fused, tetracyclic compound that includes a furan ring therein. More particularly, the present disclosure related to a process for preparing a hydrocodone compound, or a compound structurally related thereto, and in particular (+)-hydrocodone, by subjecting a structurally corresponding sinomeπine starting compound to a super acid-assisted furan ring closure reaction. Formula I, II. Examples of super acids useful in the processes described herein include, but are not limited to, trifluoromethanesulfonic acid (CF
    3 SO
    3 H), tetrafluoroboric acid (HBF
    4 ), fluorophosphoric acid (HPF
    6 ), fluorosulfuric acid (FSO
    3 H). and fiuoroantimonic acid (HSbF
    8 ), fluorophosphoric acid (FP(O)(OH)
    2 ) as well as combinations thereof.

    SINOMENINE DERIVATIVES AND PREPARATION AND USES THEREOF
    116.
    发明公开
    SINOMENINE DERIVATIVES AND PREPARATION AND USES THEREOF 审中-公开
    SINOMENIN衍生物，其制备及其应用

    公开(公告)号：EP1959956A2

    公开(公告)日：2008-08-27

    申请号：EP06847694.4

    申请日：2006-12-15

    申请人： Naturemed Group Corporation

    发明人： WANG, Jie ,  PAN, Yi

    IPC分类号： A61K31/485 ,  C07D221/28

    CPC分类号： C07D471/08 ,  C07D471/18

    摘要： The present invention relates to the preparation and pharmacological use of sinomenine derivatives of formula I . The approach disclosed herein is the modification of D ring by- substituting for R. Additional substitutions in the other rings are also provided herein. Several of the sinomenine derivatives have significantly greater anti-inflammation activity when compared with the parent compound.