公开(公告)号：EP1737876B1

公开(公告)日：2009-08-05

申请号：EP05715877.6

申请日：2005-03-09

申请人： Syngenta Participations AG

发明人： JUNG, Pierre Joseph Marcel, Syngenta Crop Protection AG ,  PITTERNA, Thomas, Syngenta Crop Protection AG ,  QUARANTA, Laura, Syngenta Crop Protection AG ,  HUETER, Ottmar Franz, Syngenta Crop Protection AG ,  MURPHY-KESSABI, Fiona, Syngenta Crop Protection AG

IPC分类号： C07H19/01 ,  A01N43/90 ,  A61K31/7048 ,  A61P33/00

CPC分类号： A01N43/90 ,  C07H19/01

摘要： A compound of the formula (I) wherein the bond between carbon atoms 22 and 23 indicated with a broken line is a single or double bond, m is 0 or 1, R1 represents a C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl group, R2 represents a hydrocarbyl group or a substituted hydrocarbyl group, and R3 and R4 represent, independently of each other, hydrogen or a chemical constituent, or either R2 and R3 together or R3 and R4 together represent a three- to seven-membered alkylene or a four- to seven-membered alkenylene bridge, for each of which at least one, preferably a CH2 group may be replaced by O, S or NR6 where R6 represents hydrogen or a hydrocarbyl group or a substituted hydrocarbyl group; or, if appropriate, an E/Z isomer and/or tautomer of the compound of formula (I), in each case in free form or in salt form.

公开(公告)号：EP1499576B1

公开(公告)日：2007-05-30

申请号：EP03724279.9

申请日：2003-04-28

申请人： Wyeth

发明人： CHIACCHIO, Ugo ,  RESCIFINA, Antonio ,  MIRAGLIA, Giuseppe ,  MAGNANO, Mariangela ,  DI RAIMONDO, Paola

IPC分类号： C07C45/30 ,  C07H19/01 ,  C07D347/00

CPC分类号： C07D347/00 ,  C07C45/30

摘要： A safe and effective process for the oxidation of a primary or secondary alcohol to the corresponding aldehyde or ketone via the reaction of said alcohol with an anhydride solution of a 1,1,1-tri(CZ-C4alkanoyloxy-1,1-dihydro-1,2-benziodoxol­ 3(1 H)-one, and a composition useful in this process.

公开(公告)号：EP1737876A1

公开(公告)日：2007-01-03

申请号：EP05715877.6

申请日：2005-03-09

申请人： Syngenta Participations AG

发明人： JUNG, P.J.M., Syngenta Crop Protection AG ,  PATERNA, Thomas, Syngenta Crop Protection AG ,  QUARANTA, Laura, Syngenta Crop Protection AG ,  HUETER, Ottmar Franz, Syngenta Crop Protection AG ,  MURPHY-KESSABI, F.M., Syngenta Crop Protection AG

IPC分类号： C07H19/01 ,  A01N43/90 ,  A61K31/7048 ,  A61P33/00

CPC分类号： A01N43/90 ,  C07H19/01

摘要： A compound of the formula (I) wherein the bond between carbon atoms 22 and 23 indicated with a broken line is a single or double bond, m is 0 or 1, R1 represents a C1-C12alkyl, C3-C8cycloalkyl or C2-C12alkenyl group, R2 represents a hydrocarbyl group or a substituted hydrocarbyl group, and R3 and R4 represent, independently of each other, hydrogen or a chemical constituent, or either R2 and R3 together or R3 and R4 together represent a three- to seven-membered alkylene or a four- to seven-membered alkenylene bridge, for each of which at least one, preferably a CH2 group may be replaced by O, S or NR6 where R6 represents hydrogen or a hydrocarbyl group or a substituted hydrocarbyl group; or, if appropriate, an E/Z isomer and/or tautomer of the compound of formula (I), in each case in free form or in salt form.

公开(公告)号：EP1671980A2

公开(公告)日：2006-06-21

申请号：EP06004047.4

申请日：1990-01-17

申请人： Merial Limited

发明人： Fisher, Michael H. ,  Mrozik, Helmut

IPC分类号： C07H19/01 ,  A61K31/70 ,  A61P33/00

CPC分类号： C07H19/01 ,  C07H17/08

摘要： Novel avermectin derivatives are disclosed, wherein the 5-hydroxy group is replaced by an oxime group. The avermectin-5-oximes can further be derivatized at the 4"- or 4'-positions as amino, substituted amino, acylhydrazone, semicarbazone, or substituted semicarbazone analogues. The avermectin-5-oximes are prepared by the oxidation of the 5-hydroxy compounds with manganese dioxide or with pyridinium dichromate to the known 5-oxo analogues, and these are then reacted with a hydroxylamine salt. The new compounds are potent anti-parasitic agents, in particular, the compounds are anthelmintic, insecticidal and acaricidal agents.

摘要翻译： 公开了新的阿维菌素衍生物，其中5-羟基被肟基替代。 阿维菌素-5-肟可以进一步在4“ - 或4'-位被衍生为氨基，取代的氨基，酰腙，缩氨基脲或取代的缩氨基脲类似物，阿维菌素-5-肟通过氧化5- 羟基化合物与二氧化锰或与重铬酸吡啶鎓转化成已知的5-氧代类似物，然后将它们与羟胺盐反应，新化合物是有效的抗寄生虫剂，特别是该化合物是驱虫剂，杀虫剂和杀螨剂。

公开(公告)号：EP1499576A1

公开(公告)日：2005-01-26

申请号：EP03724279.9

申请日：2003-04-28

申请人： Wyeth

发明人： CHIACCHIO, Ugo ,  RESCIFINA, Antonio ,  MIRAGLIA, Giuseppe ,  MAGNANO, Mariangela ,  DI RAIMONDO, Paola

IPC分类号： C07C45/30 ,  C07H19/01 ,  C07D347/00

CPC分类号： C07D347/00 ,  C07C45/30

摘要： A safe and effective process for the oxidation of a primary or secondary alcohol to the corresponding aldehyde or ketone via the reaction of said alcohol with an anhydride solution of a 1,1,1-tri(CZ-C4alkanoyloxy-1,1-dihydro-1,2-benziodoxol­ 3(1 H)-one, and a composition useful in this process.

公开(公告)号：EP0626385B1

公开(公告)日：2003-10-15

申请号：EP94810297.5

申请日：1994-05-24

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： Bulusu, A. R. C. Murty

IPC分类号： C07D498/18 ,  C07H19/01 ,  A61K31/40 ,  A61K31/445

CPC分类号： C07D498/18 ,  C07H19/01 ,  Y02P20/55

公开(公告)号：EP0808843B1

公开(公告)日：2003-03-26

申请号：EP97107089.1

申请日：1997-04-29

申请人： HIGETA SHOYU CO., LTD.

发明人： Tanaka, Yasushi ,  Komaki, Hisayuki ,  Mikami, Yuzuru ,  Yazawa, Katsukiyo ,  Kobayashi, Jun'ichi

IPC分类号： C07H19/01 ,  C07H15/26 ,  A61K31/70 ,  C12P19/58 ,  C12N1/20

CPC分类号： C07H19/01 ,  C12P19/58 ,  C12R1/365 ,  Y10S435/872

公开(公告)号：EP1022951A4

公开(公告)日：2002-06-19

申请号：EP98953552

申请日：1998-10-15

申请人： POLARX BIOPHARMACEUTICALS INC

发明人： ELLISON RALPH M ,  MERMELSTEIN FRED H

IPC分类号： C07D239/553 ,  A61K9/08 ,  A61K31/05 ,  A61K31/166 ,  A61K31/17 ,  A61K31/203 ,  A61K31/282 ,  A61K31/337 ,  A61K31/433 ,  A61K31/519 ,  A61K31/522 ,  A61K31/525 ,  A61K31/565 ,  A61K31/568 ,  A61K31/7008 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61K31/7042 ,  A61K31/7048 ,  A61K33/24 ,  A61K33/36 ,  A61K38/00 ,  A61K39/00 ,  A61K45/00 ,  A61K45/06 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  C07D305/14 ,  C07D475/04 ,  C07D519/04 ,  C07H5/06 ,  C07H15/252 ,  C07H19/01 ,  C07J41/00 ,  A01N59/22

CPC分类号： A61K45/06 ,  A61K31/568 ,  A61K33/36 ,  Y10S514/908 ,  A61K31/00 ,  A61K2300/00

公开(公告)号：EP0846123B1

公开(公告)日：2001-09-19

申请号：EP96924996.0

申请日：1996-07-18

申请人： TATE & LYLE PUBLIC LIMITED COMPANY

发明人： SANKEY, George, Henry

IPC分类号： C07H19/01

CPC分类号： C07H5/02

摘要： The flowability of crystalline sucralose can be increased by treating the crystalline material in a fluidised bed at ambient temperature with additions of water, followed by a fluidised drying phase. Fluidisation by means of an upward current of air at 25-35 DEG C and added water at 20-50 % by weight, e.g. 25-40 %, is preferred.

公开(公告)号：EP0629203B1

公开(公告)日：2001-09-12

申请号：EP93903553.1

申请日：1993-01-27

申请人： PFIZER INC.

发明人： HAUSKE, James, R. ,  SCHULTE, Gary, R.

IPC分类号： C07D498/18 ,  C07H19/01 ,  C07H17/08 ,  A61K31/435 ,  A61K31/70

CPC分类号： C07D498/18 ,  C07H19/01

摘要： Macrolides of formula (I) and methods of treatment of resistance to transplantation, fungal infections and autoimmune diseases such as rheumatoid arthritis and psoriasis using said macrolides of formula (I), wherein n is 1 or 2; A and B are taken together and form =O or A and B are taken separately and are each H or A is OH and B is H; R1 is a desosamino group; R2 is OH or a desosaminyloxy group; and R3 is an alkyl or allyl group.