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公开(公告)号：EP1644376B1
公开(公告)日：2010-09-08
申请号：EP04763132.0
申请日：2004-07-08
IPC分类号： C07D487/04 , A61K31/4162 , A61P35/00
CPC分类号： C07D487/04
摘要： Pyrrolo[3,4-c]pyrazole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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152.发明公开SUBSTITUTED DIHYDROPTERIDIN-6-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS 有权取代的二氢蝶啶-6-酮衍生物，其制备及其作为激酶抑制剂
公开(公告)号：EP2215091A2
公开(公告)日：2010-08-11
申请号：EP08856914.0
申请日：2008-11-26
IPC分类号： C07D475/00 , A61K31/519 , A61P35/00 , A61P31/00
CPC分类号： C07D475/00
摘要： Dihydropteridin-6-one derivatives of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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153.发明公开A MORPHOLINYL ANTHRACYCLINE DERIVATIVE COMBINED WITH PROTEIN KINASE INHIBITORS 审中-公开吗啉基蒽环类衍生物与蛋白激酶抑制剂
公开(公告)号：EP2182984A2
公开(公告)日：2010-05-12
申请号：EP08775293.7
申请日：2008-07-23
IPC分类号： A61K45/06 , A61P35/00 , A61K31/706
CPC分类号： A61K45/06 , A61K31/706 , A61K2300/00
摘要： The present invention provides the combined use of a morpholinyl anthracycline derivative of formula (I) as defined in the specification or a pharmaceutically acceptable salt thereof, such as nemorubicin hydrochloride, and a protein kinase (PK) inhibitor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.
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154.发明授权A HUMAN HOMOLOGUE OF THE DB4/ASK1 PROTEIN, NUCLEIC ACIDS, AND METHODS RELATED TO THE SAME 有权对DB4 / ASK1蛋白质，核酸在这个人的同源方法
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公开(公告)号：EP2176231A1
公开(公告)日：2010-04-21
申请号：EP08785975.7
申请日：2008-07-08
发明人： LOMBARDI BORGIA, Andrea , MENICHINCHERI, Maria , ORSINI, Paolo , PANZERI, Achille , PERRONE, Ettore , VANOTTI, Ermes , NESI, Marcella , MARCHIONNI, Chiara
IPC分类号： C07D231/56 , A61K31/33 , A61P35/00
CPC分类号： C07D405/14 , A61K31/496 , A61K45/06 , C07D231/56 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12
摘要： Substituted indazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a deregulated protein kinase activity, like cancer.
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公开(公告)号：EP2152236A1
公开(公告)日：2010-02-17
申请号：EP08749895.2
申请日：2008-04-30
IPC分类号： A61K9/00 , A61K31/535 , A61K31/704
CPC分类号： A61K9/0019 , A61K31/535 , A61K31/704
摘要： The present invention relates to pharmaceutical composition containing nemorubicin hydrochloride incorporated inmicrospheres. The compositions are usefulfor chemoembolisation, particularlyfor locoregional treatment of tumors.
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157.发明公开
公开(公告)号：EP2120932A1
公开(公告)日：2009-11-25
申请号：EP07857632.9
申请日：2007-12-14
发明人： BANDIERA, Tiziano , LOMBARDI BORGIA, Andrea , NESI, Marcella , PERRONE, Ettore , BOSSI, Roberto , POLUCCI, Paolo
IPC分类号： A61K31/4162 , A61P35/00
CPC分类号： C07D231/56 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D471/04
摘要： Substituted indazole derivativesof formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful in therapy in the treatment of diseases associated with a dysregulated protein kinase activity, like cancer formula (I).
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158.发明授权ANTITUMOR COMBINATION COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES AND ANTIBODIES INHIBITING GROWTH FACTORS OR THEIR RECEPTORS 有权取代的丙烯衍生物偏端霉素和生长因子或它们的受体炎症性抗体的抗肿瘤组合
公开(公告)号：EP1868599B1
公开(公告)日：2009-11-11
申请号：EP06725409.4
申请日：2006-03-29
IPC分类号： A61K31/40 , A61K39/395 , A61P35/00
CPC分类号： A61K31/40 , A61K39/395 , A61K39/39533 , A61K39/39558 , C07K2317/24 , A61K2300/00
摘要： The present invention provides the combined use of acryloyl distamycin derivatives, in particular α-bromo- and α-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and an antibody inhibiting a growth factor or its receptor, in the treatment of tumors. Also provided is the use of the said combinations in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogenesis.
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159.发明公开7-azaindol-3-ylacrylamides active as kinase inhibitors 审中-公开Als Kinasehemmer wirkende 7-Azaindol-3-ylacrylamide
公开(公告)号：EP2070928A1
公开(公告)日：2009-06-17
申请号：EP08171301.8
申请日：2008-12-11
发明人： Casuscelli, Francesco , Mongelli, Nicola , Amici, Raffaella , Traquandi, Gabriella , Menichincheri, Maria , Ermoli, Antonella
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds represented by Formula (I)
wherein R 1 and R 2 are as defined in the specification, compositions thereof, and methods of use thereof.摘要翻译： 由式（I）表示的化合物，其中R 1和R 2如说明书，其组成，及其使用方法所定义。
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160.发明公开1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors 审中-公开Als Aurora-Kinase-Inhibitoren aktive 1H-Furo [3,2-C]吡唑
公开(公告)号：EP2058315A1
公开(公告)日：2009-05-13
申请号：EP08167597.7
申请日：2008-10-27
发明人： Fancelli, Daniele , Pulici, Maurizio , Cervi, Giovanni , Quartieri, Francesca , Vianello, Paola
IPC分类号： C07D491/04
CPC分类号： C07D491/04 , C07D495/04
摘要： Furo[3,2-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention can be useful, in therapy, in the treatment of disorder or conditions associated with an altered Aurora kinase activity, such as cancer.
摘要翻译： 公开了本说明书中定义的式（I）的呋喃并[3,2-c]吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与改变的极光激酶活性例如癌症相关的病症或病症。
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