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171.发明公开NOVEL PROCESS FOR THE PREPARATION OF DIPEPTIDYL PEPTIDASE-4 (DPP-4) ENZYME INHIBITOR 审中-公开制备二肽基肽酶-4（DPP-4）酶抑制剂的新方法
公开(公告)号：EP3242879A1
公开(公告)日：2017-11-15
申请号：EP15876740.0
申请日：2015-02-20
申请人： Lee Pharma Ltd.
发明人： ALLA, Venkat Reddy , ALLA, Raghumitra , MALLEPALLI, Srinivas Reddy , NANDAM, Suresh Babu , GUDA, Madhukar Reddy , ALLURI, Raja Reddy
IPC分类号： C07D487/04 , C07D487/02 , A61P3/10
摘要： The present invention relates to a novel and improved process for the preparation of Sitagliptin of Formula (I) and its pharmaceutically acceptable salts. The present invention also relates to novel intermediates and process for the preparation of intermediates used in the preparation of Sitagliptin.
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172.发明授权N-SUBSTITUTED HETERO-BICYCLIC COMPOUNDS AND DERIVATIVES FOR COMBATING ANIMAL PESTS 有权N-SUBSTITUIERTE HETEROBICYCLISCHE VERBINDUNGEN UND DERIVATE ZURBEKÄMPFUNGVON TIERSEUCHEN
公开(公告)号：EP2694507B1
公开(公告)日：2017-03-01
申请号：EP12714646.2
申请日：2012-04-05
申请人： BASF SE
IPC分类号： C07D487/02 , C07D498/04 , C07D513/04 , A01N37/32 , A01N43/92 , A01P7/04
CPC分类号： A01N43/90 , C07D403/04 , C07D487/02 , C07D498/04 , C07D513/04
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公开(公告)号：EP2707369B1
公开(公告)日：2016-07-27
申请号：EP12782660.0
申请日：2012-05-09
申请人： Eip Pharma, LLC
发明人： ALAM, John, Jahangir
IPC分类号： C07D487/02 , A01N43/90 , A61K31/519 , A61P25/28
CPC分类号： A61K31/519 , A61K31/5025 , C07D211/16 , C07D213/82 , C07D231/40 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04 , C07D513/04
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公开(公告)号：EP2358720B1
公开(公告)日：2016-03-02
申请号：EP09821313.5
申请日：2009-10-16
发明人： DAR, Arvin , SHOKAT, Kevan M.
IPC分类号： C07D487/04 , C07D487/02 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519
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公开(公告)号：EP2986611A1
公开(公告)日：2016-02-24
申请号：EP14785167.9
申请日：2014-04-18
发明人： WANG, Weibo , ZHAO, Xingdong , YUAN, Quan , SHI, Hailong , TIAN, Qiang , LIU, Qihong , ZHOU, Zuwen , WANG, Xianlong , CHEN, Zhifang , CHEN, Ling , TAN, Haohan , FANG, Bo , JIANG, Lihua , LIU, Yanxin , SUN, Jing , ZENG, Fanxin , LI, Tongshuang
IPC分类号： C07D487/02 , A61K31/5025 , A61K31/519 , A61P29/00 , A61P35/00
CPC分类号： A61K31/5025 , C07D471/04 , C07D487/04
摘要： Disclosed herein are protein kinase inhibitors, more particularly pyridazine derivatives and pharmaceutical compositions thereof, and method of use thereof.
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176.发明公开NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS 有权NOVEL合并吡啶AS C-MET酪氨酸激酶抑制剂
公开(公告)号：EP2867223A1
公开(公告)日：2015-05-06
申请号：EP13809182.2
申请日：2013-07-01
发明人： HU, Shaojing , WANG, Fei , XU, Zhiguo , WANG, Yanping , WANG, Yinxiang
IPC分类号： C07D401/14 , C07D401/12 , C07D487/02 , A61K31/4353 , A61P35/00
CPC分类号： C07D471/04 , C07D498/04 , C07D513/04
摘要： This invention relates to novel fused quinazoline derivatives of Formula I as c-Met inhibitors, their synthesis and uses for treating c-Met mediated disorders.
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公开(公告)号：EP2382207B1
公开(公告)日：2015-04-29
申请号：EP09826421.1
申请日：2009-11-11
发明人： LIANG, Congxin , LI, Zhigang
IPC分类号： C07D413/04 , C07D413/02 , C07D487/04 , C07D487/02 , C07D265/30 , C07D407/14 , C07D403/14 , A61K31/5375 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04
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公开(公告)号：EP2707369A1
公开(公告)日：2014-03-19
申请号：EP12782660.0
申请日：2012-05-09
申请人： Eip Pharma, LLC
发明人： ALAM, John, Jahangir
IPC分类号： C07D487/02 , A01N43/90 , A61K31/519
CPC分类号： A61K31/519 , A61K31/5025 , C07D211/16 , C07D213/82 , C07D231/40 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/14 , C07D413/04 , C07D417/04 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention provides compositions for reducing amyloid plaque burden associated with Alzheimer's disease and methods of using the same.
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公开(公告)号：EP2350053B1
公开(公告)日：2013-12-11
申请号：EP09820914.1
申请日：2009-10-16
发明人： GRAY, Nathanael , CHANG, Jae, Won , ZHANG, Jianming , THOREEN, Carson, C. , KANG, Seong Woo, Anthony , SABATINI, David, M. , LIU, Qingsong
IPC分类号： C07D471/04 , C07D471/14 , C07D487/04 , C07D487/02 , A61K31/4162 , A61P3/00 , A61P3/04 , C07D498/04 , C07D519/00
CPC分类号： C07D471/04 , C07D471/14 , C07D498/04 , C07D519/00
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180.发明公开5-([1,2,3]TRIAZOL-4-YL)-7H-PYRROLO[2,3-D]PYRIMIDINDERIVATE 有权5 - （[1,2,3]三唑-4-基）-7H-吡咯并[2,3-D] PYRIMIDINDERIVATE
公开(公告)号：EP2663566A1
公开(公告)日：2013-11-20
申请号：EP11802860.4
申请日：2011-12-15
申请人： Merck Patent GmbH
IPC分类号： C07D487/02 , A61K31/437 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , A61K45/06 , C07D487/02
摘要： Compounds of the formula (I), in which R1, R2, R2a and R3 have the meanings indicated in Claim 1, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.
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