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公开(公告)号：EP2638036B1
公开(公告)日：2017-08-16
申请号：EP11839459.2
申请日：2011-11-09
发明人： KANG, Xinshan , LONG, Wei , MA, Cunbo , WANG, Yanping , SHEN, Xiaoyan , HU, Yunyan , TAN, Fenlai , WANG, Yinxiang
IPC分类号： C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D213/80 , C07D213/803 , C07D277/42 , C07D241/20 , C07D285/08 , C07D233/88 , C07D213/74 , C07D401/12 , C07D403/12 , A61K31/44 , A61K31/4178 , A61K31/444 , A61K31/433 , A61P3/08 , A61P3/10
CPC分类号： C07D417/14 , C07D213/74 , C07D213/80 , C07D213/803 , C07D233/88 , C07D241/20 , C07D277/42 , C07D285/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D417/12
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2.发明公开ICOTINIB-CONTAINING TOPICAL SKIN PHARMACEUTICAL COMPOSITION AND USE THEREOF 审中-公开ICOTINIBHALTIGE药物组合物，外用对皮肤及其用途
公开(公告)号：EP3056206A1
公开(公告)日：2016-08-17
申请号：EP14851908.5
申请日：2014-10-11
发明人： WANG, Yinxiang , YUAN, Shujun , WANG, Yanping , HU, Shaojing , HU, Yunyan
IPC分类号： A61K31/519 , A61K9/06 , A61P35/00 , A61P17/00
CPC分类号： A61K31/519 , A61K9/0014 , A61K9/06
摘要： Disclosed are topical preparations for inhibiting tyrosine kinase and preparation methods thereof, and especially topical pharmaceutical compositions for inhibiting tyrosine kinase and preparation methods thereof. The active ingredient of the topical preparations is Icotinib or a pharmaceutically acceptable salt thereof. The preparations are suitable for topical application, with minimal skin irritation, no adverse reactions such as pruritus, burning sensations, tingling, dry skin, erythema and rashes, without parahormone-related side effects such as skin atrophy, pigmentation or hypopigmentation for long-term use, as well as no related dermatological symptoms after drug withdrawal. The preparation methods are easily understood, operable, and controllable, and are suitable for industry mass production.
摘要翻译： 本发明公开了局部制剂用于抑制酪氨酸激酶及其制备方法，和爱尤其局部用药物组合物用于抑制酪氨酸激酶及其制备方法。 局部制剂中的活性成分是埃克替尼或其药学上可接受的盐。 制剂为适合局部施用，以最小的皮肤刺激，无不良反应：如瘙痒，烧灼感，麻刺感，皮肤干燥，红斑和皮疹，无需对激素相关的副作用：如皮肤萎缩，色素沉着或色素沉着不足的长期 使用，以及停药后没有相关的皮肤症状。 制备方法很容易理解的，可互操作的，可控，并且适用于工业大批量生产。
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公开(公告)号：EP2867223B1
公开(公告)日：2018-09-05
申请号：EP13809182.2
申请日：2013-07-01
发明人： HU, Shaojing , WANG, Fei , XU, Zhiguo , WANG, Yanping , WANG, Yinxiang
IPC分类号： C07D471/04 , C07D498/04 , C07D513/04 , A61K31/4353 , A61P35/00
CPC分类号： C07D471/04 , C07D498/04 , C07D513/04
摘要： This invention relates to novel fused quinazoline derivatives of Formula I as c-Met inhibitors, their synthesis and uses for treating c-Met mediated disorders.
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公开(公告)号：EP2565205B1
公开(公告)日：2015-07-01
申请号：EP11774275.9
申请日：2011-04-29
发明人： WANG, Yinxiang , TAN, Fenlai , HU, Shaojing , ZHAO, Xiangdong , MA, Cunbo , WANG, Yanping , SHEN, Xiaoyan , DING, Lieming , HU, Yunyan , CAO, Hong , LONG, Wei
IPC分类号： C07K14/605 , A61K38/26 , A61P3/10
CPC分类号： C07K14/605 , A61K38/00
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5.发明公开NOVEL FUSED PYRIDINE DERIVATIVES USEFUL AS c-MET TYROSINE KINASE INHIBITORS 有权NOVEL合并吡啶AS C-MET酪氨酸激酶抑制剂
公开(公告)号：EP2867223A1
公开(公告)日：2015-05-06
申请号：EP13809182.2
申请日：2013-07-01
发明人： HU, Shaojing , WANG, Fei , XU, Zhiguo , WANG, Yanping , WANG, Yinxiang
IPC分类号： C07D401/14 , C07D401/12 , C07D487/02 , A61K31/4353 , A61P35/00
CPC分类号： C07D471/04 , C07D498/04 , C07D513/04
摘要： This invention relates to novel fused quinazoline derivatives of Formula I as c-Met inhibitors, their synthesis and uses for treating c-Met mediated disorders.
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6.发明公开STABLE POLYMORPHIC FORMS OF COMPOUND AS HYPOXIA MIMETICS, AND USES THEREOF 审中-公开稳定多晶型形成了一个连接，HYPOXIEMIMETIKA及其用途
公开(公告)号：EP2736892A1
公开(公告)日：2014-06-04
申请号：EP12819230.9
申请日：2012-07-30
发明人： KANG, Xinshan , LONG, Wei , WANG, Fei , MA, Cunbo , ZHOU, Liufeng , HU, Yunyan , WANG, Yanping , CAO, Hong , WANG, Yinxiang , TAN, Fenlai
IPC分类号： C07D311/56 , A61K31/37 , A61P7/00
CPC分类号： C07D311/56
摘要： The polymorphic forms of the compound of Formula I, the preparation thereof including the preparation of the intermediates, the pharmaceutical compositions thereof and the uses of a polymorph above in the manufacture of medicaments for treating a disease, a disorder or a condition are disclosed.
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7.发明公开POLYMORPHIC FORMS OF COMPOUNDS AS PROLYL HYDROXYLASE INHIBITOR, AND USES THEREOF 有权化合物的多晶形式PROLYLHYDROXYLASEHEMMER及其用途
公开(公告)号：EP2734504A1
公开(公告)日：2014-05-28
申请号：EP12817360.6
申请日：2012-07-23
发明人： KANG, Xinshan , LONG, Wei , ZHANG, Jianxi , HU, Yunyan , WANG, Yinxiang
IPC分类号： C07D217/26 , A61K31/472 , A61P3/10 , A61P7/06 , A61P9/12 , A61P17/02 , A61P29/00 , A61P35/00 , A61P37/06 , A61P43/00
CPC分类号： C07D217/26 , A61K31/472 , C07B2200/13
摘要： The present invention relates to the polymorphic forms of the compound of Formula (I), preparation thereof including the preparation of intermediates and pharmaceutical compositions, and use of a polymorph above in the treatment of a disease, a disorder or a condition, or in the manufacturing of a medicament for the treatment of a disease, a disorder or a condition.
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公开(公告)号：EP2454249B1
公开(公告)日：2018-09-19
申请号：EP10799353.7
申请日：2010-07-14
发明人： KANG, Xinshan , LONG, Wei , MA, Cunbo , WANG, Yanping , CAO, Hong , WANG, Yinxiang , TAN, Fenlai , HU, Yunyan
IPC分类号： C07D311/56 , C07D405/04 , A61K31/37
CPC分类号： A61K31/37 , C07D311/56 , C07D405/04
摘要： This invention relates to new compounds that can serve as hypoxia mimetics. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one of these compounds.
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公开(公告)号：EP3008070B9
公开(公告)日：2018-05-23
申请号：EP14811414.3
申请日：2014-06-09
发明人： HU, Shaojing , LONG, Wei , WANG, Fei , WANG, Yinxiang , DING, Lieming
IPC分类号： C07D491/056 , A61K31/519 , A61P35/00
CPC分类号： C07D491/056 , A61K31/517 , A61K31/519 , A61K45/06 , C07B2200/13 , C07C57/145 , A61K2300/00
摘要： Provided are Icotinib maleate (the compound of Formula I) and polymorph forms thereof, and methods of preparing and using them.
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10.发明授权NOVEL FUSED HETEROCYCLIC DERIVATIVES USEFUL AS C-MET TYROSINE KINASE INHIBITORS 有权NEW AS C-MET酪氨酸激酶抑制剂SUITABLE稠合杂环衍生物
公开(公告)号：EP2593462B1
公开(公告)日：2016-09-07
申请号：EP11806302.3
申请日：2011-07-14
发明人： HU, Shaojing , WANG, Fei , LONG, Wei , SHEN, Xiaoyan , TAN, Fenlai , WANG, Yinxiang
IPC分类号： C07D491/056 , A61K31/517 , A61K31/4741 , A61P35/00 , A61P37/00 , A61P27/02 , A61P9/00
CPC分类号： C07D491/04 , C07D498/04
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