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公开(公告)号：EP2350053B1
公开(公告)日：2013-12-11
申请号：EP09820914.1
申请日：2009-10-16
发明人： GRAY, Nathanael , CHANG, Jae, Won , ZHANG, Jianming , THOREEN, Carson, C. , KANG, Seong Woo, Anthony , SABATINI, David, M. , LIU, Qingsong
IPC分类号： C07D471/04 , C07D471/14 , C07D487/04 , C07D487/02 , A61K31/4162 , A61P3/00 , A61P3/04 , C07D498/04 , C07D519/00
CPC分类号： C07D471/04 , C07D471/14 , C07D498/04 , C07D519/00
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公开(公告)号：EP2350053A2
公开(公告)日：2011-08-03
申请号：EP09820914.1
申请日：2009-10-16
发明人： GRAY, Nathanael , CHANG, Jae, Won , ZHANG, Jianming , THOREEN, Carson, C. , KANG, Seong Woo, Anthony , SABATINI, David, M. , LIU, Qingsong
IPC分类号： C07D401/14 , C07D403/14 , C07D487/04 , C07D487/02 , A61K31/4162 , A61P3/00 , A61P3/04
CPC分类号： C07D471/04 , C07D471/14 , C07D498/04 , C07D519/00
摘要： The present invention relates to small molecule modulators of mTORCl and mT0RC2, syntheses thereof, and intermediates thereto. Such small molecule modulators are useful in the treatment of proliferative diseases (e.g., benign neoplasms, cancers, inflammatory diseases, autoimmune diseases, diabetic retinopathy) and metabolic diseases. Novel small molecules are provided that inhibit one or more of mTORCl, mT0RC2, and PI3K-related proteins. Novel methods of providing soluble mTORCl and mT0RC2 complexes are discussed, as well as methods of using the soluble complexes in a high- throughput manner to screen for inhibitory compounds.
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公开(公告)号：EP3912973A3
公开(公告)日：2022-02-16
申请号：EP21184206.7
申请日：2008-11-28
IPC分类号： C07D239/94 , C07D487/04 , A61P9/00 , A61P17/00 , A61P19/00 , A61P35/00 , A61P35/02 , A61K31/517 , A61K31/519
摘要： The present invention provides novel heteroaryl compounds that are linked to an aryl group via an amine linker. Such compounds are useful for the treatment of cancers.
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公开(公告)号：EP3536687A1
公开(公告)日：2019-09-11
申请号：EP19170210.9
申请日：2008-11-28
IPC分类号： C07D239/94 , C07D487/04 , A61K31/517 , A61K31/519 , A61P35/00 , A61P35/02 , A61P19/00 , A61P9/00 , A61P17/00
摘要： The present invention provides novel heteroaryl compounds that are linked to an aryl group via an amine linker. Such compounds are useful for the treatment of cancers.
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公开(公告)号：EP3150593B8
公开(公告)日：2019-08-21
申请号：EP16197611.3
申请日：2008-11-28
IPC分类号： C07D403/12 , C07D403/04 , C07D403/06 , C07D239/42 , C07D239/94 , A61K45/06 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7076 , C07D417/04 , C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07H19/16
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公开(公告)号：EP3150593B1
公开(公告)日：2019-04-24
申请号：EP16197611.3
申请日：2008-11-28
IPC分类号： C07D403/12 , C07D403/04 , C07D403/06 , C07D239/42 , C07D239/94 , A61K45/06 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7076 , C07D417/04 , C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07H19/16
CPC分类号： C07D487/04 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7076 , A61K45/06 , A61P9/00 , A61P17/00 , A61P19/00 , A61P35/00 , A61P35/02 , C07D239/42 , C07D239/94 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04 , C07D473/34 , C07D495/04 , C07H19/16 , Y02A50/401
摘要： The present invention provides novel heteroaryl compounds that are linked to an aryl group via an amine linker. Such compounds are useful for the treatment of cancers.
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公开(公告)号：EP3912973A2
公开(公告)日：2021-11-24
申请号：EP21184206.7
申请日：2008-11-28
IPC分类号： C07D239/94 , C07D487/04 , A61P9/00 , A61P17/00 , A61P19/00 , A61P35/00 , A61P35/02 , A61K31/517 , A61K31/519
摘要： The present invention provides novel heteroaryl compounds that are linked to an aryl group via an amine linker. Such compounds are useful for the treatment of cancers.
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8.发明公开SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE 有权KLEINMOLEKÜLIGEMYRISTATHEMMER VON BCR-ABL UND VERWENDUNGSVERFAHREN
公开(公告)号：EP3150593A1
公开(公告)日：2017-04-05
申请号：EP16197611.3
申请日：2008-11-28
IPC分类号： C07D403/12 , C07D403/04 , C07D403/06 , C07D239/42 , C07D239/94 , A61K45/06 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7076 , C07D417/04 , C07D471/04 , C07D473/34 , C07D487/04 , C07D495/04 , C07H19/16
CPC分类号： C07D487/04 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7076 , A61K45/06 , A61P9/00 , A61P17/00 , A61P19/00 , A61P35/00 , A61P35/02 , C07D239/42 , C07D239/94 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04 , C07D473/34 , C07D495/04 , C07H19/16 , Y02A50/401
摘要： The present invention provides novel heteroaryl compounds that are linked to an aryl group via an amine linker. Such compounds are useful for the treatment of cancers.
摘要翻译： 本发明提供了通过胺连接体与芳基连接的新的杂芳基化合物。 这些化合物可用于治疗癌症。
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9.发明授权SMALL MOLECULE MYRISTATE INHIBITORS OF BCR-ABL AND METHODS OF USE 有权小分子MYRISTATHEMMER BCR-ABL及使用方法有关
公开(公告)号：EP2222162B1
公开(公告)日：2016-11-16
申请号：EP08857261.5
申请日：2008-11-28
发明人： GRAY, Nathanael, S. , ZHANG, Jianming , OKRAM, Barun , DENG, Xianming , CHANG, Jae Won , WOJCIECHOWSKI, Amy
IPC分类号： C07D403/12 , C07D403/04 , C07D239/42 , C07D417/04 , C07D473/34 , C07D487/04 , C07D495/04 , A61K45/06 , A61K31/517 , C07D403/06 , C07D239/94 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7076 , C07H19/16 , C07D471/04
CPC分类号： C07D487/04 , A61K31/517 , A61K31/519 , A61K31/52 , A61K31/5377 , A61K31/7076 , A61K45/06 , C07D239/42 , C07D239/94 , C07D403/04 , C07D403/06 , C07D403/12 , C07D417/04 , C07D471/04 , C07D473/34 , C07D495/04 , C07H19/16 , Y02A50/401
摘要： The present invention provides novel heteroaryl compounds that are linked to an aryl group via an amine linker. Such compounds are useful for the treatment of cancers.
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公开(公告)号：EP2440058A1
公开(公告)日：2012-04-18
申请号：EP10786967.9
申请日：2010-06-14
发明人： CHOI, Hwan, Geun , SIM, Taebo , GRAY, Nathanael , ZHOU, Wenjun , CHANG, Jae, Won , ZHANG, Jianming , WEISBERG, Ellen
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： C07D513/04 , A61K31/437 , A61K31/496 , A61K31/4985 , A61K31/506 , A61K31/5377
摘要： The present application relates to therapeutic organic compounds, compositions comprising an effective amount of a therapeutic organic compound; and methods for treating and preventing disease comprising administering and effective amount of a therapeutic organic compound to a subject in need thereof.
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