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11.发明公开
公开(公告)号：EP1282404A2
公开(公告)日：2003-02-12
申请号：EP01928630.1
申请日：2001-04-19
发明人： WRIGHT, Steven, G. , RICKEY, Michael, E. , RAMSTACK, J., Michael , LYONS, Shawn, L. , HOTZ, Joyce, M.
IPC分类号： A61K9/16
CPC分类号： A61K31/519 , A61K9/1647 , A61K9/1694 , B01J13/02
摘要： A method for preparing microparticles having a selected polymer molecular weight. The hold time and temperature of a solution containing a nucleophilic compound and a polymer having a starting molecular weight are controlled in order to control the molecular weight of the polymer in the finished microparticle product. In this manner, a selected polymer molecular weight in the finished microparticle product can be achieved from a variety of starting material molecular weights.
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12.发明公开APPARATUS AND METHOD FOR PREPARING MICROPARTICLES USING IN-LINE SOLVENT EXTRACTION 有权一种面向in-在线溶剂萃取设备及其制造方法的微粒
公开(公告)号：EP1242053A1
公开(公告)日：2002-09-25
申请号：EP00990484.8
申请日：2000-11-03
IPC分类号： A61K9/16
CPC分类号： A61K9/1694 , A61K9/1647 , Y10T428/2989
摘要： An emulsion is formed by combining two phases in a static mixer (140, 235). The outflow of the blending static mixer (130,230). The emulsion is conbined with an extraction liquid in a blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outlfow of the blending static mixer can be combined in a vessel (160), or through the use of a static mixer manifold (240) that includes a plurality of static mixers.
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公开(公告)号：EP1210942A2
公开(公告)日：2002-06-05
申请号：EP02075905.6
申请日：1997-05-06
IPC分类号： A61K31/519 , A61K9/58
CPC分类号： A61K9/1647 , A61K9/1694 , B01J13/02
摘要： The invention provides a particulate material comprising microparticles of a biodegradable biocompatible polymeric matrix containing an active agent and an organic solvent, said organic solvent being present in said microparticles at 2% or less of the total weight of said microparticles.
摘要翻译： 本发明提供一种颗粒材料，其包含含有活性剂和有机溶剂的可生物降解的生物相容性聚合物基质的微粒，所述微粒中存在所述微粒总重量的2％或更少的所述有机溶剂。
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公开(公告)号：EP1140029A1
公开(公告)日：2001-10-10
申请号：EP99965212.6
申请日：1999-12-10
CPC分类号： A61K9/1647 , A61K9/1694 , B01J13/02 , Y10T428/2982
摘要： An improved method for preparing microparticles that exhibit controlled release of an effective amount of an active agent over an extended period of time. More particularly, a method is provided for preparing microparticles having a selected release profile for release of active agent contained in the microparticles. By adjusting the degree of drying that is performed during the preparation of the microparticles, the release profile can be controlled. By performing no intermediate drying, an initial burst and a substantially linear release profile is achieved. By performing substantially complete intermediate drying, an initial lag phase and a substantially sigmoidal release profile is achieved.
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公开(公告)号：EP0904063A2
公开(公告)日：1999-03-31
申请号：EP97923063.0
申请日：1997-05-06
CPC分类号： B01J13/04 , A61K9/1647 , A61K9/1694 , A61K9/5089 , A61K31/519 , Y10T428/2985
摘要： The invention provides a process for the preparation of biodegradable biocompatible microparticles, said process comprising: contacting microparticles comprising a biodegradable biocompatible polymer matrix containing an active (e.g. pharmaceutical or diagnostic) agent and an organic solvent with an aqueous solvent system whereby the content of said organic solvent in said particles is reduced to 2 % or less of the weight of said particles, said solvent system being such as to satisfy at least one of the conditions (a) that it is at an elevated temperature (e.g. from 25 to 40 °C) during at least part of the time that it is in contact with said particles, and (b) that it comprises water and water-miscible solvent for said organic solvent; and recovering said particles from said aqueous solvent system.
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