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公开(公告)号：EP0904063B1
公开(公告)日：2002-09-04
申请号：EP97923063.8
申请日：1997-05-06
CPC分类号： B01J13/04 , A61K9/1647 , A61K9/1694 , A61K9/5089 , A61K31/519 , Y10T428/2985
摘要： The invention provides a process for the preparation of biodegradable biocompatible microparticles, said process comprising: contacting microparticles comprising a biodegradable biocompatible polymer matrix containing an active (e.g. pharmaceutical or diagnostic) agent and an organic solvent with an aqueous solvent system whereby the content of said organic solvent in said particles is reduced to 2 % or less of the weight of said particles, said solvent system being such as to satisfy at least one of the conditions (a) that it is at an elevated temperature (e.g. from 25 to 40 °C) during at least part of the time that it is in contact with said particles, and (b) that it comprises water and water-miscible solvent for said organic solvent; and recovering said particles from said aqueous solvent system.
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公开(公告)号：EP1420762A1
公开(公告)日：2004-05-26
申请号：EP02759445.6
申请日：2002-08-26
CPC分类号： A61K38/09 , A61K9/1641 , A61K9/1647 , A61K9/1682 , A61K9/1694 , A61K9/5089 , A61K31/519 , B01J8/025 , B01J13/08 , B01J13/12 , B01J13/206 , B01J14/00 , B01J19/121 , B01J19/122 , B01J19/2415 , B01J2219/0877
摘要： Methods for preparing microparticles having reduced residual solvent levels, Microparticles are contacted with a non-aqueous washing system to reduce the level of residual solvent in the microparticles, Preferred non-aqueous washing systems include 100% ethanol and a blend of ethanol and heptane. A solvent blend of a hardening solvent and a washing solvent can be used to harden and wash microparticles in a single step, thereby eliminating the need for a post-hardening wash step.
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3.发明公开
公开(公告)号：EP1282404A2
公开(公告)日：2003-02-12
申请号：EP01928630.1
申请日：2001-04-19
发明人： WRIGHT, Steven, G. , RICKEY, Michael, E. , RAMSTACK, J., Michael , LYONS, Shawn, L. , HOTZ, Joyce, M.
IPC分类号： A61K9/16
CPC分类号： A61K31/519 , A61K9/1647 , A61K9/1694 , B01J13/02
摘要： A method for preparing microparticles having a selected polymer molecular weight. The hold time and temperature of a solution containing a nucleophilic compound and a polymer having a starting molecular weight are controlled in order to control the molecular weight of the polymer in the finished microparticle product. In this manner, a selected polymer molecular weight in the finished microparticle product can be achieved from a variety of starting material molecular weights.
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公开(公告)号：EP0904063A2
公开(公告)日：1999-03-31
申请号：EP97923063.0
申请日：1997-05-06
CPC分类号： B01J13/04 , A61K9/1647 , A61K9/1694 , A61K9/5089 , A61K31/519 , Y10T428/2985
摘要： The invention provides a process for the preparation of biodegradable biocompatible microparticles, said process comprising: contacting microparticles comprising a biodegradable biocompatible polymer matrix containing an active (e.g. pharmaceutical or diagnostic) agent and an organic solvent with an aqueous solvent system whereby the content of said organic solvent in said particles is reduced to 2 % or less of the weight of said particles, said solvent system being such as to satisfy at least one of the conditions (a) that it is at an elevated temperature (e.g. from 25 to 40 °C) during at least part of the time that it is in contact with said particles, and (b) that it comprises water and water-miscible solvent for said organic solvent; and recovering said particles from said aqueous solvent system.
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