公开(公告)号：EP1628664A2

公开(公告)日：2006-03-01

申请号：EP04754164.4

申请日：2004-06-03

申请人： Alkermes Controlled Therapeutics, Inc. II

发明人： BRITTAIN, Harry, A. ,  DICKASON, David, A. ,  HOTZ, Joyce ,  LYONS, Shawn, L. ,  RAMSTACK, Michael, J. ,  WRIGHT, Steven, G.

IPC分类号： A61K31/485

CPC分类号： A61K31/485 ,  C07B2200/13 ,  C07C19/03 ,  C07D489/06 ,  C07D489/08

摘要： This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorporating them, including sustained release, or long acting, formulations.

公开(公告)号：EP1140029B1

公开(公告)日：2005-11-09

申请号：EP99965212.6

申请日：1999-12-10

申请人： Alkermes Controlled Therapeutics Inc. II

发明人： LYONS, Shawn, L. ,  RAMSTACK, Michael, J. ,  WRIGHT, Steven, G.

IPC分类号： A61K9/16 ,  B01J13/04 ,  B01J13/20

CPC分类号： A61K9/1647 ,  A61K9/1694 ,  B01J13/02 ,  Y10T428/2982

摘要： An improved method for preparing microparticles that exhibit controlled release of an effective amount of an active agent over an extended period of time. More particularly, a method is provided for preparing microparticles having a selected release profile for release of active agent contained in the microparticles. By adjusting the degree of drying that is performed during the preparation of the microparticles, the release profile can be controlled. By performing no intermediate drying, an initial burst and a substantially linear release profile is achieved. By performing substantially complete intermediate drying, an initial lag phase and a substantially sigmoidal release profile is achieved.

公开(公告)号：EP1231898A2

公开(公告)日：2002-08-21

申请号：EP00991722.0

申请日：2000-11-03

申请人： Alkermes Controlled Therapeutics Inc. II

发明人： LYONS, Shawn, L. ,  WRIGHT, Steven, G.

IPC分类号： A61K9/16

CPC分类号： A61K9/1694 ,  A61K9/1682 ,  Y10T428/2985

摘要： Apparatus and method for preparing microparticles. An emulsion is formed by combining two phases in a static mixing assembly (730). The static mixing assembly preferably includes a preblending static mixer (732) and a manifold (734). The emulsion flows out of the static mixing assembly into a quench liquid whereby droplets of the emulsion form microparticles. The residence time of the emulsion in the static mixing assembly is controlled to obtain a predetermined particle size distribution of the resulting microparticles.

公开(公告)号：EP1242053B1

公开(公告)日：2005-01-12

申请号：EP00990484.8

申请日：2000-11-03

申请人： Alkermes Controlled Therapeutics Inc. II

发明人： LYONS, Shawn, L. ,  WRIGHT, Steven, G.

IPC分类号： A61K9/16

CPC分类号： A61K9/1694 ,  A61K9/1647 ,  Y10T428/2989

摘要： An emulsion is formed by combining two phases in a static mixer (140, 235). The outflow of the blending static mixer (130,230). The emulsion is conbined with an extraction liquid in a blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outlfow of the blending static mixer can be combined in a vessel (160), or through the use of a static mixer manifold (240) that includes a plurality of static mixers.

公开(公告)号：EP1282404A2

公开(公告)日：2003-02-12

申请号：EP01928630.1

申请日：2001-04-19

申请人： Alkermes Controlled Therapeutics Inc. II

发明人： WRIGHT, Steven, G. ,  RICKEY, Michael, E. ,  RAMSTACK, J., Michael ,  LYONS, Shawn, L. ,  HOTZ, Joyce, M.

IPC分类号： A61K9/16

CPC分类号： A61K31/519 ,  A61K9/1647 ,  A61K9/1694 ,  B01J13/02

摘要： A method for preparing microparticles having a selected polymer molecular weight. The hold time and temperature of a solution containing a nucleophilic compound and a polymer having a starting molecular weight are controlled in order to control the molecular weight of the polymer in the finished microparticle product. In this manner, a selected polymer molecular weight in the finished microparticle product can be achieved from a variety of starting material molecular weights.

公开(公告)号：EP1242053A1

公开(公告)日：2002-09-25

申请号：EP00990484.8

申请日：2000-11-03

申请人： Alkermes Controlled Therapeutics Inc. II

发明人： LYONS, Shawn, L. ,  WRIGHT, Steven, G.

IPC分类号： A61K9/16

CPC分类号： A61K9/1694 ,  A61K9/1647 ,  Y10T428/2989

摘要： An emulsion is formed by combining two phases in a static mixer (140, 235). The outflow of the blending static mixer (130,230). The emulsion is conbined with an extraction liquid in a blending static mixer is combined with additional extraction liquid. The additional extraction liquid and the outlfow of the blending static mixer can be combined in a vessel (160), or through the use of a static mixer manifold (240) that includes a plurality of static mixers.

公开(公告)号：EP1140029A1

公开(公告)日：2001-10-10

申请号：EP99965212.6

申请日：1999-12-10

申请人： Alkermes Controlled Therapeutics Inc. II

发明人： LYONS, Shawn, L. ,  RAMSTACK, Michael, J. ,  WRIGHT, Steven, G.

IPC分类号： A61K9/16 ,  B01J13/04 ,  B01J13/20

CPC分类号： A61K9/1647 ,  A61K9/1694 ,  B01J13/02 ,  Y10T428/2982

摘要： An improved method for preparing microparticles that exhibit controlled release of an effective amount of an active agent over an extended period of time. More particularly, a method is provided for preparing microparticles having a selected release profile for release of active agent contained in the microparticles. By adjusting the degree of drying that is performed during the preparation of the microparticles, the release profile can be controlled. By performing no intermediate drying, an initial burst and a substantially linear release profile is achieved. By performing substantially complete intermediate drying, an initial lag phase and a substantially sigmoidal release profile is achieved.