PROCESS FOR THE PREPARATION OF 3-CEPHEM COMPOUNDS
    13.
    发明公开
    PROCESS FOR THE PREPARATION OF 3-CEPHEM COMPOUNDS 有权
    用于生产-3-头孢衍生物

    公开(公告)号:EP1010701A4

    公开(公告)日:2001-07-11

    申请号:EP99926869

    申请日:1999-06-30

    申请人: OTSUKA KAGAKU KK

    CPC分类号: C07D501/00

    摘要: A process for the preparation of 3-cephem compounds, characterized by reacting a β-lactam compound represented by general formula (1) with a phosphorus halide compound in the presence of an organic base to form an imino-β-lactam compound represented by general formula (2), adding a phenol to the resulting reaction system to conduct alcoholysis simultaneously with the deblocking of the carboxylate ester, and thus obtaining a 3-cephem compound represented by general formula (3) or a salt thereof, wherein R1, R2, R3 and X are each as defined in the description.

    CUT-FLOWER FRESHNESS RETENTIVE
    14.
    发明公开
    CUT-FLOWER FRESHNESS RETENTIVE 有权
    FRISCHHALTEMITTELFÜRSCHNITTBLUMEN

    公开(公告)号:EP1075790A9

    公开(公告)日:2001-04-04

    申请号:EP98953017

    申请日:1998-11-11

    申请人: OTSUKA KAGAKU KK

    IPC分类号: A01N3/02 A01N59/00 A01N59/06

    CPC分类号: A01N3/02

    摘要: An excellent cut-flower freshness retentive containing 0.8-2 wt.% of at least one sugar, 100-1,000 ppm of at least one potassium salt in terms of K
    2 O, and 1-30 ppm of at least one compound selected from among aluminum and zinc salts and hydrates thereof in terms of Al or Zn.

    摘要翻译: 包含0.8-2重量%的至少一种糖,100-1,000ppm的至少一种以K 2 O换算的钾盐的优异的切花保鲜保持性和1-30ppm的至少一种选自铝 以及以Al或Zn计的锌盐和水合物。

    PROCESS FOR PRODUCING EXO-METHYLENEPENAM COMPOUNDS
    16.
    发明公开
    PROCESS FOR PRODUCING EXO-METHYLENEPENAM COMPOUNDS 失效
    VERFAHREN ZUR HERSTELLUNG VON EXO-METHYLENPENAM-DERIVATEN

    公开(公告)号:EP0999213A4

    公开(公告)日:2000-05-10

    申请号:EP98905768

    申请日:1998-03-05

    申请人: OTSUKA KAGAKU KK

    CPC分类号: C07D499/00

    摘要: A process for preparing an exo-methylenepenam compound represented by the formula (2) wherein cephem compound represented by the formula (1) is reduced with a metal having a standard oxidation-reduction potential of up to -0.3 (V/SCE) in an amount of at least one mole per mole of the cephem compound and with a metal compound having a higher standard oxidation reduction potential than the metal in an amount of 0.0001 to 10 moles per mole of the cephem compound to obtain the exo-methylenepenam compound wherein R is a hydrogen atom, amino or protected amino, R is a hydrogen atom, halogen atom, etc. R is a hydrogen atom or carboxylic acid protective group, X is a halogen atom, etc. wherein R , R and R are as defined above.d

    摘要翻译: 制备通式(2)的外型 - 亚甲基戊酰胺化合物的方法,其中R1代表氢原子,氨基或被保护的氨基; R2代表氢原子,卤素原子等; 和R 3代表氢原子或羧基保护基,其特征在于还原通式(1)的头孢烯化合物,其中R 1,R 2和R 3各自如上所定义; X表示卤素原子等,至少等摩尔量的标准氧化还原电位为-0.3(V / SCE)以下的金属和0.0001〜30摩尔每摩尔化合物的 具有比金属高的标准氧化还原电位的金属化合物。

    PROCESS FOR THE PREPARATION OF 3-ALKOXYMETHYLCEPHEMS
    17.
    发明公开
    PROCESS FOR THE PREPARATION OF 3-ALKOXYMETHYLCEPHEMS 失效
    VERFAHREN ZUR HERSTELLUNG VON 3-ALKOXYMETHYLCEPHEMEN

    公开(公告)号:EP0831156A4

    公开(公告)日:1999-05-19

    申请号:EP97906850

    申请日:1997-03-07

    申请人: OTSUKA KAGAKU KK

    CPC分类号: C25B3/02

    摘要: A process for the preparation of 3-alkoxymethylcephems, characterized by electrolytically oxidizing a 3-thiomethylcephem of general formula (I) (wherein R1 is hydrogen, amino or protected amino; R2 is optionally substituted aryl; and R3 is hydrogen or a carboxyl-protecting group) in the presence of a lower alcohol into a 3-alkoxymethylcephem of general formula (II) (wherein R1, R2 and R3 are each as defined above; and R4 is lower alkyl).

    摘要翻译: 一种制备3-烷氧基甲基头孢的方法,其特征在于电解氧化通式(I)的3-硫代甲基头孢烯(其中R1是氢,氨基或被保护的氨基; R2是任选取代的芳基;并且R3是氢或羧基保护 (II)(式中,R 1,R 2和R 3与上述相同,R 4为低级烷基)的3-烷氧基甲基头孢烯在低级醇的存在下进行反应。

    PROCESS FOR THE PRODUCTION OF BETA-LACTAM COMPOUNDS
    19.
    发明公开
    PROCESS FOR THE PRODUCTION OF BETA-LACTAM COMPOUNDS 失效
    PROCESS FORβ-内酰胺化合物的制备

    公开(公告)号:EP0759428A4

    公开(公告)日:1998-11-11

    申请号:EP96905014

    申请日:1996-03-07

    申请人: OTSUKA KAGAKU KK

    CPC分类号: C07D499/00 C07D205/09

    摘要: A process for the production of a halogenated β-lactam compound represented by general formula (2) which comprises replacing the hydroxyl group of a halogenated β-lactam compound represented by general formula (1) with a halogen atom or a leaving group. Another process for the production of an exomethylene penam compound represented by general formula (5) which comprises reducing a halogenated β-lactam compound represented by general formula (2) with at least the equimolar amount of a metal having a standard oxidation-reduction potential of -0.3 (V/SCE) or below and 0.0001 to 10 times by mol as much a metal compound having a standard oxidation-reduction potential higher than that of the former metal, or employing the electrolytic reduction method.

    CARRIER AND AGRICULTURAL MATERIAL.
    20.
    发明公开
    CARRIER AND AGRICULTURAL MATERIAL. 失效
    CARRIER和农业设备。

    公开(公告)号:EP0654211A4

    公开(公告)日:1997-05-28

    申请号:EP94917143

    申请日:1994-06-02

    申请人: OTSUKA KAGAKU KK

    摘要: A carrier having small weight and high water and fertilizer holding properties, and capable of immobilizing a large quantity of plant cultivating culture medium, which can be disposed of simply after it has been used, and which does not give rise to any environmental problems, and also a large quantity of microorganisms, greatly improving the survival rate of microorganisms which have been preserved for a long period of time, and being used as a microorganism immobilizing carrier capable of greatly improving the establishing rate and reproductive rate of microorganisms. The carrier contains polysaccharide and lignin as main components, and has cellular structures in the inner portion thereof.