公开(公告)号：EP1641462B1

公开(公告)日：2010-11-24

申请号：EP04747335.0

申请日：2004-07-05

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/5575 ,  A61K9/28

CPC分类号： A61K9/2846 ,  A61K9/2866 ,  A61K9/4891 ,  A61K31/00 ,  A61K31/5575 ,  A61K31/558

摘要： The present invention provides an enteric coated composition for oral administration of a chloride channel opener which can provide improved pharmaceutical activity with reduced adverse side effect such as nausea.

公开(公告)号：EP1857105B1

公开(公告)日：2010-08-11

申请号：EP07016834.9

申请日：2001-09-04

申请人： Sucampo AG

发明人： Ueno, Ryuji

IPC分类号： A61K31/35 ,  A61K31/335 ,  A61P1/10

CPC分类号： C07C405/00 ,  A61K31/335 ,  A61K31/35 ,  A61K31/352 ,  A61K31/4741 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/559 ,  C07D221/04 ,  C07D335/04 ,  Y10S514/892 ,  A61K2300/00

公开(公告)号：EP0978284B1

公开(公告)日：2008-07-23

申请号：EP98953058.9

申请日：1998-11-16

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/5575 ,  A61P3/10 ,  A61P9/00 ,  A61P27/02

CPC分类号： A61K31/5575 ,  A61K31/557

摘要： An antagonist against endothelin believed to relate to the causes of diseases such as hypertension, Buerger's disease, asthma, eyeground diseases, and the like. The antagonist comprises a 15-ketoprostaglandin E compound, especially, a 13,14-dihydro15-keto-16-mono- or dihalogenoprostaglandin.

公开(公告)号：EP1315485B1

公开(公告)日：2007-11-21

申请号：EP01961333.0

申请日：2001-09-04

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/35 ,  A61P1/10

CPC分类号： C07C405/00 ,  A61K31/335 ,  A61K31/35 ,  A61K31/352 ,  A61K31/4741 ,  A61K31/557 ,  A61K31/5575 ,  A61K31/559 ,  C07D221/04 ,  C07D335/04 ,  Y10S514/892 ,  A61K2300/00

摘要： An object of the present invention is to provide an anti-constipation composition containing a halogenated-bi-cyclic compound as an active ingredient in a ratio of bi-cyclic/mono-cyclic structure of at least 1 : 1. The halogenated-bi-cyclic compound is represented by Formula (I): where X1 and X2 are preferably both fluorine atoms. The composition can be used to treat constipation without substantive side-effects, such as stomachache.

公开(公告)号：EP1223925B1

公开(公告)日：2006-11-02

申请号：EP00944426.6

申请日：2000-07-13

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/201 ,  A61K31/202 ,  A61K31/5575 ,  A61P27/02 ,  A61P1/00

CPC分类号： A61K31/5575 ,  A61K9/0048 ,  A61K9/0056 ,  A61K31/20 ,  A61K31/201 ,  A61K31/202 ,  A61K31/557 ,  A61K31/558 ,  A61K31/5585 ,  A61K49/0008

摘要： Disclosed is a composition for treatment of external secretion disorders comprising, as an active ingredient a fatty acid derivative. The composition of the present invention is useful for treatment of at least one condition selected from hypolacrimation including disorder of basal tear secretion, dry-eye syndrome, hyposalivation and dry-mouth syndrome.

公开(公告)号：EP1173177B1

公开(公告)日：2004-11-03

申请号：EP00921047.7

申请日：2000-04-26

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/436 ,  A61P27/02

CPC分类号： A61K31/436 ,  A61K31/4745

摘要： The present invention provides an agent for treating a dry eye, which contains a macrolide compound such as FK506.

公开(公告)号：EP1443938A1

公开(公告)日：2004-08-11

申请号：EP02780083.8

申请日：2002-11-14

申请人： Sucampo AG

发明人： UENO, Ryuji ,  PATCHEN, Myra, L.

IPC分类号： A61K31/557 ,  A61P1/10

CPC分类号： C07D311/94 ,  A61K31/557 ,  C07C53/23

摘要： A dosage unit for treating constipation in a human patient is described. The dosage unit of the invention comprises a halogenated prostaglandin analog and a pharmaceutically suitable excipient. The dosage unit relieves constipation without substantial side effects.

公开(公告)号：EP1420794A1

公开(公告)日：2004-05-26

申请号：EP02767866.3

申请日：2002-08-29

申请人： Sucampo AG

发明人： UENO, Ryuji ,  CUPPOLETTI, John

IPC分类号： A61K31/557 ,  C07C405/00

CPC分类号： C07C405/00 ,  A61K31/557

摘要： Disclosed is a novel use of a prostaglandin compound as a chloride channel opener. According to the instant invention, chloride channels in a mammalian subject can be opened by a prostaglandin compound to facilitate chloride ion transportation.

摘要翻译： 公开了前列腺素化合物作为氯化物通道开放剂的新用途。 根据本发明，哺乳动物受试者的氯化物通道可以由前列腺素化合物打开，以促进氯离子转运。

公开(公告)号：EP1392318A1

公开(公告)日：2004-03-03

申请号：EP02720623.4

申请日：2002-04-26

申请人： Sucampo AG

发明人： UENO, Ryuji

IPC分类号： A61K31/557 ,  A61P1/10

CPC分类号： A61K31/557 ,  A61K31/485 ,  A61K31/5575 ,  A61K2300/00

摘要： Provided is a composition for treatment of drug-induced constipation comprising a 15-keto-prostaglandin compound as an active ingredient. The composition of the present invention has a strong antagonistic action against drug-induced constipation without substantially losing the main effect of the drug.

公开(公告)号：EP1267882A2

公开(公告)日：2003-01-02

申请号：EP01914192.8

申请日：2001-03-23

申请人： Sucampo AG

发明人： UENO, Ryuji ,  MASHIMA, Yukihiko

IPC分类号： A61K31/557 ,  A61P9/10 ,  A61P25/28 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00

CPC分类号： A61K31/557 ,  A61K31/5575 ,  A61K31/558 ,  Y10S514/912

摘要： Disclosed is a new use of 15-keto-prostaglandin compound as an apoptosis inhibitor. Said compound can inhibit apoptosis effectively and is useful for treatment of a subject such as a human having a disease or condition associated with apoptosis.