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    Vitamin D glycosides and sulfates for treating intestinal diseases
    14.
    发明公开
    Vitamin D glycosides and sulfates for treating intestinal diseases 审中-公开
    维生素D糖苷和硫酸盐zur Behandlung von Darmerkrankungen

    公开(公告)号：EP2695617A2

    公开(公告)日：2014-02-12

    申请号：EP13174890.7

    申请日：2010-12-23

    申请人： Glycomyr Inc.

    发明人： Goff, Jesse ,  Horst, Ronald

    IPC分类号： A61K31/592 ,  A61K31/593 ,  A61K31/7032 ,  A61K31/7034 ,  A61K45/06 ,  A61P35/00 ,  A61P37/02 ,  A61P31/04

    CPC分类号： A61K31/593 ,  A61K31/592 ,  A61K31/7032 ,  A61K31/7034 ,  A61K45/06 ,  A61K47/549 ,  A61P35/00 ,  A61P37/02 ,  Y02A50/475 ,  Y02A50/481 ,  A61K2300/00

    摘要： Disclosed are methods of treating vitamin D-sensitive diseases without inducing severe forms of hypercalcemia. The methods comprise administering biologically inert vitamin D prodrugs. The vitamin D prodrugs have a vitamin D-drug moiety and a pro moiety, wherein the pro moiety is selected from the group consisting of a glycone moiety and a sulfate moiety. The vitamin D prodrugs are activated by enzymes at target tissues or cells that cleave the pro moiety from the vitamin D-drug moiety, freeing the vitamin D-moiety from the pro moiety in the vicinity of the target tissues or cells. In some versions, the vitamin D-drug moiety is an active vitamin D drug that has direct therapeutic effects at target sites. In other versions, the vitamin D-drug moiety is an inactive vitamin D drug that regulates the production and/or turnover of an active vitamin D drug and, therefore, abundance of the active vitamin D drug at the target site. The methods of the invention prevent large, acute, systemic increases in the free form of the vitamin D-drug moiety that would otherwise lead to hypercalcemia. The methods can be used to treat hyperproliferative, autoimmune, or infectious diseases throughout the body, including the intestine. Compositions of the vitamin D prodrugs useful in the described methods are also disclosed.

    摘要翻译： 公开了治疗维生素D敏感性疾病而不引起严重形式的高钙血症的方法。 所述方法包括施用生物惰性维生素D前药。 维生素D前药具有维生素D-药物部分和前体部分，其中前体部分选自糖基部分和硫酸酯部分。 维生素D前药通过在靶组织或细胞上被酶活化，所述细胞从维生素D药物部分切割该部分，从目标组织或细胞附近的亲部分释放出维生素D部分。 在某些版本中，维生素D药物部分是活性维生素D药物，在目标部位具有直接的治疗作用。 在其他版本中，维生素D药物部分是一种不活动的维生素D药物，其调节活性维生素D药物的产生和/或更替，因此在目标部位调节活性维生素D药物的丰富。 本发明的方法防止维生素D-药物部分的游离形式的大量急性系统性增加，否则会导致高钙血症。 该方法可用于治疗全身，包括肠道的过度增生，自身免疫或感染性疾病。 还公开了在所述方法中有用的维生素D前药的组合物。

    METHODS AND COMPOSITIONS FOR TAGGING AND IDENTIFYING POLYNUCLEOTIDES
    16.
    发明授权
    METHODS AND COMPOSITIONS FOR TAGGING AND IDENTIFYING POLYNUCLEOTIDES 有权
    方法和组合物标识和识别多核苷酸

    公开(公告)号：EP1848827B1

    公开(公告)日：2013-10-30

    申请号：EP06734218.8

    申请日：2006-02-03

    申请人： Population Genetics Technologies Ltd.

    发明人： BRENNER, Sydney

    IPC分类号： C12Q1/68 ,  C12N15/10

    CPC分类号： C12Q1/6874 ,  C12N15/1065 ,  C12N15/1093 ,  C12P19/34 ,  C12Q1/6827 ,  C12Q1/6837 ,  Y10T436/143333 ,  C12Q2565/514 ,  C12Q2563/179 ,  C12Q2537/143 ,  C12Q2525/191

    摘要： The invention provides methods and compositions for attaching oligonucleotide tags to polynucleotides for the purpose of carrying out analytical assays in parallel and for decoding the oligonucleotide tags of polynucleotides selected in such assays. Words, or subunits, of oligonucleotide tags index submixtures in successively more complex sets of submixtures (referred to herein as "tiers" of submixtures) that a polynucleotide goes through while successive words are added to a growing tag. By identifying each word of an oligonucleotide tag, a series of submixtures is identified including the first submixture that contains only a single polynucleotide, thereby providing the identity of the selected polynucleotide. The analysis of the words of an oligonucleotide tag can be carried out in parallel, e.g. by specific hybridization of the oligonucleotide tag to its tag complement on an addressable array; or such analysis can be carried out serially by successive specific hybridizations of labeled word complements, or the like.

    DEVICES AND METHODS USEFUL FOR SEALING BODILY OPENINGS
    18.
    发明公开
    DEVICES AND METHODS USEFUL FOR SEALING BODILY OPENINGS 审中-公开
    装置和方法可用于密封机身开口

    公开(公告)号：EP2571428A2

    公开(公告)日：2013-03-27

    申请号：EP11723801.4

    申请日：2011-05-19

    申请人： Cook Medical Technologies LLC ,  Cook Biotech Incorporated

    发明人： PAUL, Ram, H. ,  STANLEY, Cleon ,  BATES, Brian, L. ,  OBERMILLER, F., Joseph ,  OSBORNE, Thomas, A. ,  CHAMBERS, Sean

    IPC分类号： A61B17/00

    CPC分类号： A61B17/0057 ,  A61B17/3468 ,  A61B2017/00004 ,  A61B2017/00592 ,  A61B2017/00597 ,  A61B2017/00623 ,  A61B2017/00628 ,  A61B2017/00641 ,  A61B2017/00659 ,  A61B2017/00663 ,  A61B2017/0496 ,  A61B2017/06176

    摘要： Among other things, there are disclosed apparatuses and methods for medically sealing an opening in a vessel or wall. For example, in medical applications, a delivery tube is provided for insertion through a sheath into a vessel (e.g. a blood vessel). A dome-shaped seal fixed to a filament, an absorbent and/or compressible buffer, and a locking member are provided in the delivery tube. The delivery tube is configured so that it can be inserted into the vessel through a sheath. Tension is maintained on the filament to hold the seal against the tube or sheath. The sheath is pulled out, which pulls out the tube at the same time, leaving the seal over the opening in the vessel wall. The locking member compresses the buffer against the outside of the vessel and with the filament holds the seal in place against the inside of a vessel.

    摘要翻译： 除其他之外，公开了用于医​​学密封血管或壁中的开口的设备和方法。 例如，在医疗应用中，提供输送管（24）以通过鞘（22）插入血管（例如血管）中。 在输送管中提供固定到细丝（28）的圆顶形密封件（26），吸收和/或可压缩缓冲器（30）以及锁定构件（32）。 输送管被构造成可以通过护套插入血管中。 在灯丝上保持张力以将密封保持在管或护套上。 拉出护套，同时拉出管，将密封留在血管壁的开口上。 锁定构件将缓冲器压向容器的外部，并且细丝将密封件保持在抵靠容器内部的适当位置。