摘要:
A solid sustained release pharmaceutical composition comprising a compressed mixture of a pharmacologically active ingredient and a sustained release carrier comprising xanthan gum characterised in that the xanthan gum is capable of dissolving in water at a concentration of 1 part by weight xanthan gum to 100 parts by weight water to form a solution having a transmittance (600 nm) of greater than 50 %. The clarified xanthan gum has an improved reproducibility in drug dissolution.
摘要:
The primer contains at least one compound selected from organosilanes R 1 -(CH 2 ) a -(O-(CH 2 ) c ) b -Si-[(O-(CH 2 ) c ) b -OR 2 ] 3 wherein a=0-4, b=0-1, c=1-4, R 1 is -CH 3 , -NH 3 , -CH=CH 2 , -CH-CH 2 -O l and R 2 is -CH 3 or -C 2 H 5 , and/or epoxy adducts of phosphoric acid. It dispenses with the use of acid and/or toxic pretreatment solutions, and allows two-coat systems to be applied in one pass on standard coil coating lines.
摘要:
The present invention relates to novel agropolymers, which comprise a carbohydrate and/or silica matrix substantially devoid of proteins, tannins and polyphenols and which comprise metal binding reactive sites. A method of producing the agropolymers is also disclosed wherein the agropolymers are derived from plant materials such as seed coats, seed covers, husks, or hulls of various agricultural crops. The agricultural crops typically used to produce the agropolymers include Oryza sativa, Panicum miliaceum, Setaria italica, Cajanus cajan, Vigna mungo, Vigna radiata, Triticum sp., Ricinus communis, Helianthus annus, Gossypium sp., and Arachis sp. The agropolymers of the present invention are capable of purifying aqueous solutions polluted or contaminated with metals and/or ions. Thus, the present invention also discloses a method whereby agropolymers are used in the purification of contaminated water and other aqueous solutions. The agropolymers disclosed herein are useful in several industrial applications including purifying polluted drinking water or ground water.
摘要:
A secondary panel (12) is arranged such that it is in a non-operational position when the vehicle to which it is fitted is moving or operating normally, and may be moved into a security position adjacent window (11) when the vehicle is empty and locked to provide much greater resistance to unauthorised entry.
摘要:
A method of protein engineering is provided wherein a searchable computer database is created comprising entries in the form of descriptions of a location and orientation in 3D space of side chains of the constituent amino acid residues of a framework protein. A query is created which corresponds to a description of a location and orientation in 3D space of respective side chains of amino acid residues of a sample protein. The location and orientation in 3D space of constituent side-chains is preferably described as a Cα-Cβ vector. The query is used to search the database and thereby identify a hit which corresponds to a framework protein having structural similarity with said sample protein. Framework protein 'hits' so identified may be suitable candidates for further modification. A particular advantage of the present invention is that a modified framework protein may display one or more desired characteristics, such as a function similar to or inhibitory of the sample protein.
摘要:
A method of protein engineering is provided wherein a searchable computer database is created comprising entries in the form of descriptions of a location and orientation in 3D space of side chains of the constituent amino acid residues of a framework protein. A query is created which corresponds to a description of a location and orientation in 3D space of respective side chains of amino acid residues of a sample protein. The location and orientation in 3D space of constituent side-chains is preferably described as a Cα-Cβ vector. The query is used to search the database and thereby identify a hit which corresponds to a framework protein having structural similarity with said sample protein. Framework protein 'hits' so identified may be suitable candidates for further modification. A particular advantage of the present invention is that a modified framework protein may display one or more desired characteristics, such as a function similar to or inhibitory of the sample protein.
摘要:
A process for the preparation of a pharmaceutical composition in the form of agglomerates comprising 70-97 % by weight of 2-(4-isobutylphenyl)propionic acid or a pharmaceutically acceptable salt thereof and 3-30 % by weight of a starch component, said process comprising the steps of a) forming an emulsion comprising 1) 70-97 % by weight of 2-(4-isobutylphenyl)propionic acid or a salt thereof; 2) a solvent system; 3) 3-30 % by weight of the starch component; 4) water and optionally 5) a surfactant; b) crystallising to produce a suspension comprising crystals of 2-(4-isobutylphenyl)propionic acid or the salt thereof in intimate contact with the starch component; c) agitating said suspension to form agglomerates comprising an evenly distributed mixture of 2-(4-isobutylphenyl)propionic acid or a salt thereof and the starch component; d) collecting said agglomerates and optionally e) drying said agglomerates. Pharmaceutical formulations comprising 90-99.98 % by weight of such a composition together with 0.02-10 % of a pharmaceutically acceptable excipient are also described, which are suitable for direct compression into tablets. Preferably the starch component comprises a mixture of maize starch and pregelled maize starch.