公开(公告)号：EP4368642A3

公开(公告)日：2024-07-17

申请号：EP24153914.7

申请日：2018-06-19

申请人： The Regents of the University of California

发明人： AMICUCCI, Matthew, J. ,  PARK, Dayoung ,  GALERMO, Ace, Gita ,  MILLS, David, A. ,  GERMAN, John, Bruce ,  LEBRILLA, Carlito, B.

IPC分类号： A61K31/715 ,  C08B37/00

CPC分类号： C07H1/00 ,  C07H1/08 ,  C08B37/00 ,  C12P19/04 ,  C07H3/06 ,  C12P19/00

摘要： Methods of generating oligosaccharides are provided.

公开(公告)号：EP2880144B1

公开(公告)日：2024-05-01

申请号：EP12882337.4

申请日：2012-08-03

IPC分类号： C11D3/37 ,  C08L5/00 ,  C08B13/00 ,  C08B15/00 ,  C08B37/00 ,  C08L3/02

CPC分类号： C08L5/00 ,  C11D3/222 ,  C11D3/3757 ,  C08B15/00 ,  C08B37/00 ,  C08B37/0033 ,  C08L3/02 ,  C08L33/066 ,  C08L33/08 ,  C08F251/00

公开(公告)号：EP3406635A1

公开(公告)日：2018-11-28

申请号：EP18177128.8

申请日：2008-03-20

申请人： Wyeth LLC

发明人： Yuan, Yonghui ,  Ruppen, Mark ,  Sun, Wei-Qiang ,  Chu, Ling ,  Simpson, John ,  Patch, James ,  Fink Charbonneau, Pamela ,  Moran, Justin K.

IPC分类号： C08B37/00 ,  A61K47/64 ,  C12P19/04

CPC分类号： A61K39/092 ,  A61K39/00 ,  A61K47/646 ,  A61K2039/6087 ,  A61K2039/62 ,  C07H1/08 ,  C08B37/00 ,  C08B37/0003 ,  C12P19/04

摘要： A shortened process for producing a solution containing substantially purified capsular polysaccharides from a cellular Streptococcus pneumoniae lysate broth is described. Ultrafiltering and diafiltering a clarified S. pneumoniae lysate followed by pH adjustment to less than 4.5, preferably about 3.5, precipitated at least 98% of the protein in the solution without seriously affecting polysaccharide yield. Furthermore, following ultrafiltration and diafiltration and acidification to a pH of less than 4.5, filtration using activated carbon precipitated at least 90% of remaining protein without seriously affecting polysaccharide yield. Exemplary, non-limiting S . pneumoniae serotypes that can be purified using the shortened process of the invention are 1, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F.

公开(公告)号：EP2436700B8

公开(公告)日：2018-08-01

申请号：EP11194173.8

申请日：2008-03-20

申请人： Wyeth LLC

发明人： Yuan, Yonghui ,  Ruppen, Mark ,  Sun, Wei-Qiang ,  Chu, Ling ,  Simpson, John ,  Patch, James ,  Fink Charbonneau, Pamela ,  Moran, Justin K.

IPC分类号： C08B37/00 ,  A61K47/64 ,  C12P19/04

CPC分类号： A61K39/092 ,  A61K39/00 ,  A61K47/646 ,  A61K2039/6087 ,  A61K2039/62 ,  C07H1/08 ,  C08B37/00 ,  C08B37/0003 ,  C12P19/04

摘要： A shortened process for producing a solution containing substantially purified capsular polysaccharides from a cellular Streptococcus pneumoniae lysate broth is described. Ultrafiltering and diafiltering a clarified S. pneumoniae lysate followed by pH adjustment to less than 4.5, preferably about 3.5, precipitated at least 98% of the protein in the solution without seriously affecting polysaccharide yield. Furthermore, following ultrafiltration and diafiltration and acidification to a pH of less than 4.5, filtration using activated carbon precipitated at least 90% of remaining protein without seriously affecting polysaccharide yield. Exemplary, non-limiting S. pneumoniae serotypes that can be purified using the shortened process of the invention are 1, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. In one embodiment, the Streptococcus pneumoniae cells are lysed using deoxycholate sodium (DOC), while in another embodiment the lytic agent is a non-animal derived lytic agent such as N-lauryl sarcosine sodium (NLS).

公开(公告)号：EP2436700B1

公开(公告)日：2018-06-20

申请号：EP11194173.8

申请日：2008-03-20

申请人： Wyeth LLC

发明人： Yuan, Yonghui ,  Ruppen, Mark ,  Sun, Wei-Qiang ,  Chu, Ling ,  Simpson, John ,  Patch, James ,  Fink Charbonneau, Pamela ,  Moran, Justin K.

IPC分类号： C08B37/00 ,  A61K47/64 ,  C12P19/04

CPC分类号： A61K39/092 ,  A61K39/00 ,  A61K47/646 ,  A61K2039/6087 ,  A61K2039/62 ,  C07H1/08 ,  C08B37/00 ,  C08B37/0003 ,  C12P19/04

摘要： A shortened process for producing a solution containing substantially purified capsular polysaccharides from a cellular Streptococcus pneumoniae lysate broth is described. Ultrafiltering and diafiltering a clarified S. pneumoniae lysate followed by pH adjustment to less than 4.5, preferably about 3.5, precipitated at least 98% of the protein in the solution without seriously affecting polysaccharide yield. Furthermore, following ultrafiltration and diafiltration and acidification to a pH of less than 4.5, filtration using activated carbon precipitated at least 90% of remaining protein without seriously affecting polysaccharide yield. Exemplary, non-limiting S. pneumoniae serotypes that can be purified using the shortened process of the invention are 1, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. In one embodiment, the Streptococcus pneumoniae cells are lysed using deoxycholate sodium (DOC), while in another embodiment the lytic agent is a non-animal derived lytic agent such as N-lauryl sarcosine sodium (NLS).

公开(公告)号：EP3280719A1

公开(公告)日：2018-02-14

申请号：EP16733123.0

申请日：2016-04-07

申请人： Centre National de la Recherche Scientifique ,  Université de Montpellier

发明人： GRISON, Claude ,  ESCANDE, Vincent

IPC分类号： C07H1/00 ,  C07D309/10 ,  C07H3/00 ,  C07H3/06 ,  C08B37/00

CPC分类号： C07H1/00 ,  C07D309/10 ,  C07H3/00 ,  C07H3/06 ,  C08B37/00

摘要： The present invention relates to the use of sodium dithionite to reduce at least one aldehyde or ketone function of a carbohydrate, C-glycoside, oligosaccharide, or water-soluble polysaccharide in the absence of a water-immiscible organic solvent and in the absence of a phase transfer agent. The invention also relates to a preparation method that includes treating a carbohydrate, a C-glycoside, an oligosaccharide, or a water-soluble polysaccharide with sodium dithionite.

公开(公告)号：EP3149026A4

公开(公告)日：2018-01-24

申请号：EP15803011

申请日：2015-06-01

申请人： B G NEGEV TECH AND APPLICATIONS LTD

发明人： COHEN SMADAR ,  BRIK ASHRAF

IPC分类号： C07K7/50 ,  C07C251/36 ,  C07K7/02 ,  C08L1/04 ,  C08L5/02 ,  C08L5/08 ,  C08L5/10

CPC分类号： C08B37/0072 ,  C07K9/001 ,  C07K14/4747 ,  C08B37/00 ,  C08B37/0021 ,  C08B37/003 ,  C08B37/0084

摘要： The present invention relates to site-selective modification of polysaccharides at their reducing end by conjugation with a single aminoxy-Regioselective Addressable Functionalized Template (RAFT) peptide.

公开(公告)号：EP2118145B1

公开(公告)日：2017-05-17

申请号：EP08737594.5

申请日：2008-01-11

申请人： GlaxoSmithKline Biologicals SA

发明人： BARDOTTI, Angela ,  BERTI, Francesco ,  COSTANTINO, Paolo

IPC分类号： C08B37/00 ,  A61K39/095 ,  A61K47/50 ,  C07H13/00

CPC分类号： C08B37/00 ,  A61K39/095 ,  A61K47/646 ,  A61K2039/55505 ,  A61K2039/6037 ,  C07H13/00 ,  C08B37/006

摘要： Modified capsular saccharides comprising a blocking group at a hydroxyl group position on at least one of the monosaccharide units of the corresponding native capsular saccharide, wherein the blocking group is of the formula (Ia) or (Ib): -O-X-Y (Ia) or -O-R 1 (Ib) wherein X is C(O), S(O) or SO 2 ; Y is NR 1 R 2 or R 3 ; R 1 is C 1-6 alkyl substituted with 1, 2 or 3 groups independently selected from hydroxyl, sulphydryl and amine; R 2 is H or C 1-6 alkyl; and R 3 is C 1-6 alkyl; processes for modifying a capsular saccharide with the blocking groups; saccharide-protein conjugates comprising the modified capsular saccharide; processes for making the saccharide-protein conjugates, pharmaceutical compositions comprising the modified capsular saccharides and/or saccharide-protein conjugates; and methods and uses of the same.

摘要翻译： 在相应的天然荚膜糖的至少一个单糖单元上的羟基位置上含有封闭基团的改性荚膜糖，其中所述封闭基团为式（Ia）或（Ib）：-OXY（Ia）或 - OR 1（Ib）其中X为C（O），S（O）或SO 2; Y是NR 1 R 2或R 3; R 1是独立地选自羟基，巯基和胺的1,2或3个基团取代的C 1-6烷基; R 2是H或C 1-6烷基; 和R 3是C 1-6烷基; 用阻聚基修饰荚膜糖的方法; 包含修饰的荚膜糖的糖 - 蛋白质缀合物; 制备糖 - 蛋白质缀合物的方法，包含改性荚膜糖和/或糖 - 蛋白质缀合物的药物组合物; 以及相同的方法和用途。

公开(公告)号：EP3162895A1

公开(公告)日：2017-05-03

申请号：EP15811514

申请日：2015-06-24

申请人： TOSOH CORP

发明人： ASAOKA YOSHIHARU ,  TANAKA TORU ,  TERAO YOSUKE ,  YAMANAKA NAOKI ,  KIZU NATSUKO ,  AOKI MASARU ,  IDE TERUHIKO

IPC分类号： C12N15/09 ,  C07K1/22 ,  C07K14/735 ,  C07K16/00 ,  C08B37/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12P21/02 ,  G01N30/26 ,  G01N30/88

CPC分类号： C07K14/70535 ,  B01D15/3809 ,  C07K1/22 ,  C07K16/00 ,  C07K16/065 ,  C07K2317/10 ,  C07K2317/41 ,  C07K2317/732 ,  C08B37/00 ,  C12N5/10 ,  C12N15/09 ,  C12P21/02 ,  G01N30/482 ,  G01N33/6854 ,  G01N2030/486 ,  G01N2400/02

摘要： Provided are: an Fc-binding protein having improved stability, particularly to heat and acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent. Specifically provided are: an Fc-binding protein having improved stability to heat and acid, achieved by substituting an aminoacid residue in a specific position in the extracellular region of human FcyRIIIa with another specific amino acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent.

摘要翻译： 提供有：Fc结合蛋白具有改进的稳定性，特别是对热和酸; 用于产生蛋白质的方法; 使用蛋白抗体吸附剂; 和使用该吸附剂中分离所述抗体的方法。 具体地提供的是：向Fc结合蛋白具有改善的稳定性，对热和酸，通过在人FcγRIIIa的与另一种特定氨基酸的胞外区中的特定位置的氨基酸残基的替换实现; 用于产生蛋白质的方法; 使用蛋白抗体吸附剂; 和使用该吸附剂中分离所述抗体的方法。

公开(公告)号：EP3162813A1

公开(公告)日：2017-05-03

申请号：EP15003137

申请日：2015-11-02

申请人： MERZ PHARMA GMBH & CO KGAA

发明人： ABEL ULRICH ,  KRAUSE ANDREAS

IPC分类号： C08B37/00 ,  A61K8/73 ,  A61K31/728 ,  A61K31/738 ,  C08B37/08 ,  C08L5/08

CPC分类号： C08B37/0072 ,  A61K8/042 ,  A61K8/33 ,  A61K8/735 ,  A61K31/728 ,  A61K31/738 ,  A61K2800/805 ,  A61K2800/91 ,  A61Q19/08 ,  C08B37/00 ,  C08L5/08

摘要： The present invention relates to a process for depleting epoxide species in epoxy-crosslinked polysaccharide gel compositions. In addition, the present invention relates to crosslinked polysaccharide gel compositions made by said process and their use in cosmetic and therapeutic applications.

摘要翻译： 本发明涉及一种用于在环氧交联的多糖凝胶的组合物的环氧化物消耗物种的方法。 此外，本发明涉及通过所述方法，及其在化妆品和治疗应用中使用由交联的多糖凝胶的组合物。