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11.发明公开INDUCING CELLULAR IMMUNE RESPONSES TO PROSTATE CANCER ANTIGENS USING PEPTIDE AND NUCLEIC ACID COMPOSITIONS 审中-公开诱导细胞免疫应答抗前列腺癌抗原通过肽和核酸CONNECTIONS
公开(公告)号：EP1244465A1
公开(公告)日：2002-10-02
申请号：EP00989560.8
申请日：2000-12-20
申请人： Epimmune Inc.
发明人： FIKES, John , SETTE, Alessandro , SIDNEY, John , SOUTHWOOD, Scott , CHESNUT, Robert , CELIS, Esteban , KEOGH, Elissa
IPC分类号： A61K38/08 , A61K39/00 , A61K39/385 , A61K39/39 , C07H21/04 , C07K14/435
CPC分类号： C07K14/4748 , A61K39/00
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12.发明公开INDUCING CELLULAR IMMUNE RESPONSES TO HER2/neu USING PEPTIDE AND NUCLEIC ACID COMPOSITIONS 审中-公开用肽和核酸组合物诱导HER2 / neu细胞免疫应答
公开(公告)号：EP1239866A1
公开(公告)日：2002-09-18
申请号：EP00984214.7
申请日：2000-12-11
申请人： Epimmune Inc.
发明人： FIKES, John , SETTE, Alessandro , SIDNEY, John , SOUTHWOOD, Scott , CHESNUT, Robert , CELIS, Esteban , KEOGH, Elissa
IPC分类号： A61K38/00 , A61K38/03 , A61K38/08 , A61K38/10 , A61K38/16 , C07K7/00 , C07K9/00 , C07K14/435 , C07H21/02 , C07H21/04
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/5154 , A61K2039/605 , C07K14/71
摘要： This invention uses our knoeledge of the mechanisms by which antigen is recognized by T cells to identify and prepare HER2/neu epitopes, and to develop epitope-based vaccines directed towards HERS2/neu-bearing tumors. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of cancer.
摘要翻译： 本发明使用我们对T细胞识别和制备HER2 / neu表位以及开发针对HERS2 / neu的肿瘤的基于表位的疫苗的机制的了解。 更具体地说，该应用传达了我们对药物组合物的发现和用于预防和治疗癌症的方法。
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13.发明公开INDUCING CELLULAR IMMUNE RESPONSES TO CARCINOEMBRYONIC ANTIGEN USING PEPTIDE AND NUCLEIC ACID COMPOSITIONS 审中-公开STIMULUSCULLÄRER免疫反应一个CARCINOEMBRYONEN抗原肽使用和核酸组合物
公开(公告)号：EP1235848A1
公开(公告)日：2002-09-04
申请号：EP00984204.8
申请日：2000-12-11
申请人： Epimmune Inc.
发明人： FIKES, John , SETTE, Alessandro , SIDNEY, John , SOUTHWOOD, Scott , CHESNUT, Robert , CELIS, Esteban , KEOGH, Elissa
IPC分类号： C07H21/04 , C07H21/02 , C07K4/12 , C07K7/00 , C07K9/00 , C07K14/705 , A61K38/04 , A61K38/08 , A61K38/10 , A61K38/17
CPC分类号： A61K39/0011 , A61K39/00 , A61K2039/5154 , A61K2039/605 , C07K14/70503
摘要： This invention uses our knowledge of the mechanisms by which antigen is recognized by T cells to identify and prepare carcino-embryonic antigen (CEA) epitopes, and to develop epitope-based vaccines directed towards CEA-bearing tumors. More specifically, this application communicates our discovery of pharmaceutical compositions and methods of use in the prevention and treatment of cancer.
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14.发明授权METHODS FOR (EX VIVO) THERAPY USING PEPTIDE-LOADED ANTIGEN PRESENTING CELLS FOR THE ACTIVATION OF CTL 失效对于（离体）治疗的方法通过肽 - 放倒抗原 - CTL呈递细胞活化
公开(公告)号：EP0726941B1
公开(公告)日：2002-04-03
申请号：EP94924539.3
申请日：1994-08-01
申请人： Epimmune Inc.
发明人： CELIS, Esteban , KUBO, Ralph , SERRA, Horacio , TSAI, Van , WENTWORTH, Peggy
CPC分类号： C12N5/0636 , A61K2039/5158 , C12N2502/11 , Y02A50/412
摘要： Methods for activating cytotoxic T lymphocytes (CTL) in vitro are presented in conjunction with methods for using the activated CTL for therapy in vivo. Additionally, a method for killing specific CTL in vivo is presented using antigen presenting cells which were modified in vitro.
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15.发明公开
公开(公告)号：EP1018344A2
公开(公告)日：2000-07-12
申请号：EP00102538.6
申请日：1992-08-26
申请人： Epimmune, Inc.
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/57 , C07K2319/00 , C12N2730/10122
摘要： Cytotoxic T lymphocyte-stimulating peptides induce HLA-restricted responses to hepatitis B virus antigens. The peptides, derived from CTL epitopic regions of both HBV surface and nucleocapsid antigens, are particularly useful in the treatment and prevention of HBV infection, including the treatment of chronically infected HBV carriers. The peptides can be formulated as HBV vaccines and pharmaceutical compositions, such as lipid-containing compositions for enhancing the HLA-restricted CTL responses. The peptides are also useful in diagnostic methods, such as predicting which HBV-infected individuals are prone to developing chronic infection.
摘要翻译： 细胞毒性T淋巴细胞刺激肽诱导HLA受限于乙型肝炎病毒抗原的应答。 衍生自HBV表面和核衣壳抗原的CTL表位区的肽特别可用于治疗和预防HBV感染，包括治疗慢性感染的HBV携带者。 肽可以配制成HBV疫苗和药物组合物，例如用于增强HLA限制性CTL应答的含脂质组合物。 这些肽也可用于诊断方法，例如预测哪些HBV感染个体易发展为慢性感染。
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公开(公告)号：EP0914142A1
公开(公告)日：1999-05-12
申请号：EP97914975.0
申请日：1997-03-10
申请人： Epimmune, Inc.
摘要： Ther present invention provides immunogenic peptides comprising an HLA-A3 supermotif. The peptides can be used to treat, diagnose, or monitor a number of pathological conditions.
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公开(公告)号：EP1767542A3
公开(公告)日：2012-12-12
申请号：EP05075377.1
申请日：1997-03-21
申请人： Epimmune Inc.
发明人： Grey, Howard M , Sette, Alessandro , Sidney, John
CPC分类号： C07K14/005 , A61K39/00 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2770/24222
摘要： Peptides of antigens of HCV and HBV are disclosed, together with nucleotides encoding the peptides. The peptides may be used in the treatment or prevention of HCV or HBV infection.
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18.发明授权PEPTIDES WITH INCREASED BINDING AFFINITY FOR AT LEAST THREE HLA-A3-LIKE MOLECULES 失效以增加的亲和力肽绑定至少三HLA-A3样分子
公开(公告)号：EP0914142B9
公开(公告)日：2012-01-04
申请号：EP97914975.4
申请日：1997-03-10
申请人： Epimmune Inc.
IPC分类号： A61K38/03 , A61K39/002 , A61K39/02 , A61K39/12
摘要： Ther present invention provides immunogenic peptides comprising an HLA-A3 supermotif. The peptides can be used to treat, diagnose, or monitor a number of pathological conditions.
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公开(公告)号：EP1578432A4
公开(公告)日：2008-07-30
申请号：EP03768519
申请日：2003-10-03
申请人： EPIMMUNE INC
发明人： SIDNEY JOHN , SOUTHWOOD SCOTT , SETTE ALESSANDRO
IPC分类号： A61K39/00 , C07K14/35 , C07K14/47 , C07K14/705 , C07K14/74 , A61K31/711 , A61K38/00 , C07H21/04 , C07K7/00
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/35 , C07K14/4746 , C07K14/4748 , C07K14/705 , C07K14/70503 , C07K14/70539 , C07K14/82 , C07K2319/01 , C12N2710/16222 , C12N2730/10122 , C12N2740/16122 , C12N2740/16222 , C12N2770/24222
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20.发明公开HLA-A1, A2 -A3,-A24,-B7,AND -B44 TUMOR ASSOCIATED ANTIGEN PEPTIDES AND COMPOSITIONS 审中-公开HLA-A1，A2，A3，A24，-B7和-B44TUMOR相关的抗原肽和组合物
公开(公告)号：EP1583548A4
公开(公告)日：2007-10-17
申请号：EP03812851
申请日：2003-12-10
申请人： EPIMMUNE INC
IPC分类号： A61K38/00 , C07K14/47 , C07K14/705 , C07K14/71
CPC分类号： C07K14/4746 , A61K38/00 , C07K14/4748 , C07K14/70503 , C07K14/71
摘要： A peptide or composition comprising at least one epitope or analog from CEA, HER2/neu, MAGE2, MAGE3, or p53.
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