公开(公告)号：EP1603919B1

公开(公告)日：2008-12-17

申请号：EP04719039.2

申请日：2004-03-10

申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. ,  ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： DALLAVALLE, Sabrina ,  PENCO, Sergio ,  PISANO, C., Sigma-Tau Indus. Farma. Riunite S.p.A ,  ZUNINO, F., Istit. Nazion. Studio Cura dei Tumori

IPC分类号： C07D491/22 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D491/22

摘要： Camptothecin derivatives of camptothecin of formula (I), wherein the groups R1, R2 and R3 are as defined in the description are disclosed. The compounds of formula (I) are endowed with antitumor activity and show a good therapeutic index. Processes for the preparation of the compounds of formula (I) and their use in the preparation of medicaments useful in the treatment of tumors, viral infections and antiplasmodium falciparum are also disclosed.

公开(公告)号：EP1753776A1

公开(公告)日：2007-02-21

申请号：EP05742726.2

申请日：2005-05-04

申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. ,  ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： DAL POZZO, Alma; c/o Istituto di Ricerche Chimiche ,  PENCO, Sergio ,  MERLINI, Lucio ,  GIANNINI, Giuseppe; c/o Sigma-Tau Industrie Farmac ,  TINTI, Maria, Ornella; c/o Sigma-Tau Industrie Far ,  PISANO, Claudio; c/o Sigma-Tau Industrie Farmaceut ,  ZUNINO, Franco; Istituto Nazionale per lo Studio e ,  ALLOATTI, Domenico; c/o Sigma-Tau Industrie Farmac ,  VESCI, Loredana; c/o Sigma-Tau Industrie Farmaceut ,  DALLAVALLE, Sabrina ,  NI MING HONG; c/o Istituto di Ricerche Chimiche e

IPC分类号： C07K7/64 ,  A61K38/08

CPC分类号： C07K7/52 ,  A61K38/00

摘要： Compounds of Formula (I) are described in which the R1 group is as defined in the specification and includes the condensation of the camptothecin molecule in position 7 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors αvβ3 and αvβ5 and with selective cytotoxic activity on human tumor cell lines at micromolar concentrations.

公开(公告)号：EP1747020A2

公开(公告)日：2007-01-31

申请号：EP05743414.4

申请日：2005-04-28

申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. ,  ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： DAL POZZO, Alma ,  PENCO, Sergio ,  MERLINI, Lucio ,  GIANNINI, G., Simgma-Tau Ind. Farm. Riunite S.p.A. ,  TINTI, M., Sigma-Tau Ind. Farm. Riunite S.p.A. ,  PISANO, C., Sigma-Tau Ind. Farm. Riunite S.p.A. ,  ZUNINO, F., Ist. Naz. per Studio e CuradeiTumori ,  ALLOATTI, D., Simgma-Tau Ind. Farm. Riunite S.p.A. ,  VESCI, L., Sigma-Tau Ind. Farm. Riunite S.p.A. ,  DALLAVALLE, Sabrina ,  NI MING, Hong Ist. di Ricerche Chimiche e Biochim.

IPC分类号： A61K47/48 ,  A61P35/00 ,  A61P35/04 ,  A61P33/00 ,  A61P31/12

CPC分类号： A61K47/64

摘要： Compounds of Formula (I) are described; in which the R1 group is as defined in the specification and includes the condensation of 7-t-butoxyiminomethylcamptothecin in position 20 with a cyclopeptide containing the RGD sequence. Said compounds are endowed both with high affinity for integrin receptors αvβ3 and αvβ5 and with selective cytotoxic activity on human tumour cell lines at micromolar concentrations.

公开(公告)号：EP1454992B1

公开(公告)日：2006-05-31

申请号：EP03005186.6

申请日：2003-03-07

申请人： ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： Pinna, Lorenzo A. ,  Donella-Deana, Arianna ,  Marin, Oriano ,  Mologni, Luca ,  Gunby, Rosalind ,  Gambacorti Passerini, Carlo ,  Scapozza, Leonardo

IPC分类号： C12Q1/48 ,  C07K14/72 ,  G01N33/74 ,  A61K31/00

CPC分类号： C12N9/1205 ,  A61K31/5395 ,  C12Q1/485 ,  G01N33/74 ,  G01N2500/04

公开(公告)号：EP1459682A1

公开(公告)日：2004-09-22

申请号：EP04006186.3

申请日：2004-03-16

申请人： ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI ,  MHT S.r.l.

发明人： Marchesini, Renato Angelo ,  Tomatis, Stefano Maria ,  Carrara, Mauro ,  Berner, Markus

IPC分类号： A61B5/103

CPC分类号： A61B5/444 ,  A61B5/0059 ,  A61B5/445 ,  A61B5/7264

摘要： An apparatus is described, for the characterisation of pigmented skin lesions, which comprises an instrument for the acquisition of a plurality of images of the lesion, filmed with lighting at different wavelengths, means designed to segment and parameterise each of said images, means designed to extrapolate a data set from said images and input said data into a neural network system, means designed to compare the results processed by said neural network with the results obtained following similar processing of known cases, and means designed to vary the weighting of each parameter supplied to the neural network on the basis of said results.

摘要翻译： 描述了一种用于表征色素性皮肤病变的装置，其包括用于获取病灶的多个图像的仪器，用不同波长的照明成像，用于分割和参数化每个所述图像的装置，被设计为 从所述图像推断数据集并将所述数据输入到神经网络系统中，被设计为将由所述神经网络处理的结果与已知情况类似处理后获得的结果进行比较的装置，以及被设计为改变提供的每个参数的权重的装置 以神经网络为基础的结果。

公开(公告)号：EP1044977B1

公开(公告)日：2002-05-02

申请号：EP99830124.6

申请日：1999-03-09

申请人： SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. ,  ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： Penco, Sergio ,  Merlini, Lucio ,  Carminati, Paolo c/o Sigma-Tau Ind.Farm.Riun.S.p.A ,  Zunino, Franco c/o Sigma-Tau Ind.Farm.Riun.S.p.A

IPC分类号： C07D491/22 ,  A61K31/435

CPC分类号： C07D491/22

公开(公告)号：EP0663832B1

公开(公告)日：2001-04-18

申请号：EP94924299.4

申请日：1994-07-29

申请人： POLICLINICO SAN MATTEO, ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO DI DIRITTO PUBBLICO ,  ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： MERLINI, Giampaolo ,  GIANNI, Luca

IPC分类号： A61K31/704

CPC分类号： A61K31/70 ,  Y10S514/908

摘要： The use of 4'-iodo-4'-deoxydoxorubicin and its pharmaceutically acceptable salts in the treatment of amyloidosis is described.

公开(公告)号：EP0627226B1

公开(公告)日：1998-12-16

申请号：EP94108354.5

申请日：1994-05-31

申请人： ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： Severini, Aldo

IPC分类号： A61L31/00

CPC分类号： A61L31/10 ,  A61F2/82 ,  A61F2002/30067 ,  B29C37/0017 ,  B29C41/08 ,  B29C41/20 ,  B29K2075/00 ,  B29K2101/12 ,  B29K2105/0073 ,  B29K2827/18 ,  B29K2995/0056 ,  B29L2031/7532 ,  C08L75/04 ,  C08G18/44

公开(公告)号：EP0231005A2

公开(公告)日：1987-08-05

申请号：EP87101016.1

申请日：1987-01-24

申请人： ISTITUTO NAZIONALE PER LO STUDIO E LA CURA DEI TUMORI

发明人： Silvestrini, Rosella

IPC分类号： C12Q1/06

CPC分类号： C12Q1/06 ,  G01N33/5005 ,  Y10S435/81

摘要： Kit for use in the determination of the proliferative activity in human tumours, characterized mainly by a container containing, in assembled and lyophilized form, the four basic components (culture medium, antibiotic, serum and radioactive metabolic precursor) necessary to fix the tumoural material fragments rapidly and easily, without any fear of degradation and granting reliable results.

公开(公告)号：EP2528936B1

公开(公告)日：2014-10-22

申请号：EP11710271.5

申请日：2011-01-20

申请人： Consiglio Nazionale Delle Ricerche ,  IRCCS- Istituto Nazionale Per Lo Studio E La Cura Dei Tumori "Fondazione Giovanni Pascale"

发明人： AMODEO, Pietro ,  VITALE, Rosamaria ,  DE LUCA, Stefania ,  SCALA, Stefania ,  CASTELLO, Giuseppe ,  SIANI, Alfredo

IPC分类号： C07K7/06 ,  C07K7/56 ,  A61K38/12

CPC分类号： C07K7/64 ,  A61K38/00 ,  C07K7/06