公开(公告)号：EP1496986A1

公开(公告)日：2005-01-19

申请号：EP03726188.0

申请日：2003-04-04

申请人： Ichor Medical Systems Inc.

发明人： BERNARD, Robert, M. ,  HANNAMAN, Andrew, W. ,  BERNARD, Brady, M. ,  MASTERSON, Steven, P.

IPC分类号： A61N1/18

CPC分类号： A61M5/2033 ,  A61M5/20 ,  A61M5/2053 ,  A61M5/30 ,  A61M5/326 ,  A61M5/46 ,  A61M2005/206 ,  A61N1/30 ,  A61N1/306

摘要： Methods and apparatus for the reproducible, consistent and efficacious delivery of a therapeutic agent to a patient. The invention comprises means for the controlled administration of the therapeutic agent through an orifice to the patient, a plurality of penetrating electrodes arranged with a predetermined spatial relationship relative to the orifice, and means for generating an electrical signal operatively connected to the electrodes.

公开(公告)号：EP0973579A4

公开(公告)日：2000-11-02

申请号：EP98918621

申请日：1998-04-23

申请人： ICHOR MEDICAL SYSTEMS INC ,  BERNARD ROBERT M

发明人： BERNARD ROBERT M

IPC分类号： A61N1/30 ,  A61N1/32

CPC分类号： A61N1/0424 ,  A61N1/044 ,  A61N1/0476 ,  A61N1/306 ,  A61N1/325 ,  A61N1/326 ,  A61N1/327

摘要： Electrodes and electrode array apparatus and systems for in vivo delivery of electrical waveforms rendering therapeutic benefit to the patient are disclosed.

公开(公告)号：EP2929909A1

公开(公告)日：2015-10-14

申请号：EP15165174.2

申请日：2005-03-08

申请人： Ichor Medical Systems Inc.

发明人： Masterson, Steven P. ,  Hannaman, Andrew W. ,  Bernard, Robert M.

IPC分类号： A61N1/32 ,  A61N1/08 ,  A61N1/30

CPC分类号： A61N1/0502 ,  A61N1/08 ,  A61N1/30 ,  A61N1/325 ,  A61N1/327

摘要： Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes a least in their deployed state.

公开(公告)号：EP1729848A4

公开(公告)日：2011-04-13

申请号：EP05725237

申请日：2005-03-08

申请人： ICHOR MEDICAL SYSTEMS INC

发明人： MASTERSON STEVEN P ,  HANNAMAN ANDREW W ,  BERNARD ROBERT M

IPC分类号： A61N1/30 ,  A61N1/08 ,  A61N1/32

CPC分类号： A61N1/0502 ,  A61N1/08 ,  A61N1/30 ,  A61N1/325 ,  A61N1/327

公开(公告)号：EP1729848A1

公开(公告)日：2006-12-13

申请号：EP05725237.1

申请日：2005-03-08

申请人： Ichor Medical Systems Inc.

发明人： MASTERSON, Steven, P. ,  HANNAMAN, Andrew, W. ,  BERNARD, Robert, M.

IPC分类号： A61N1/30

CPC分类号： A61N1/0502 ,  A61N1/08 ,  A61N1/30 ,  A61N1/325 ,  A61N1/327

摘要： Apparatus for the delivery of an electrical field which facilitates the intracellular delivery of a therapeutic agent to a predetermined site within the tissue of a patient. The apparatus will comprise a plurality of penetrating electrodes arranged in a predetermined spatial relationship, each electrode with a cross sectional area contributing to the total cross sectional area of all electrodes, and structural means incorporating an inanimate source of energy operatively connected to the plurality of electrodes for deploying the electrodes, wherein the source of energy is sufficient to impart a force of at least 1000 pounds per square inch (0.7 kilogram per square millimeter) of total cross sectional area of all electrodes at the initiation of the deployment of the electrodes. The apparatus will also comprise means for generating an electrical field which facilitates the intracellular delivery of a therapeutic agent, which means is operatively connected to said electrodes at least in their deployed state.

摘要翻译： 用于递送电场的装置，其有助于将治疗剂细胞内递送到患者组织内的预定部位。 该装置将包括以预定空间关系布置的多个穿透电极，每个电极具有有助于所有电极的总横截面面积的横截面面积，以及结合装置，其结合有可操作地连接到多个电极的无生命力源 用于展开电极，其中能量源足以在电极展开开始时施加至少1000磅/平方英寸（0.7千克/平方毫米）所有电极的总横截面面积的力。 该装置还将包括用于产生促进治疗剂的细胞内递送的电场的装置，该装置至少在其展开状态下可操作地连接到所述电极。