公开(公告)号：EP2515655A1

公开(公告)日：2012-10-31

申请号：EP10842538.0

申请日：2010-12-15

申请人： Samumed, LLC

发明人： HOOD, John ,  KC, Sunil, Kumar ,  WALLACE, David, Mark

IPC分类号： A01N43/52 ,  A01N43/56 ,  A61K31/415

CPC分类号： A61K31/5377 ,  A61K31/415 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  C07D401/14 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D519/00

摘要： Provided herein are compounds according to Formula (I) and pharmaceutically acceptable salts thereof, and compositions comprising the same, for use in various methods, including treating cancers such as colon, ovarian, pancreatic, breast, liver, prostate and hematologic cancers.

公开(公告)号：EP2987487B1

公开(公告)日：2020-10-07

申请号：EP15177852.9

申请日：2010-08-09

申请人： Samumed, LLC

发明人： HOOD, John ,  WALLACE, David Mark ,  KC, Sunil Kumar

IPC分类号： A61K31/416 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  A01N43/52 ,  C07D231/56 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D409/12 ,  C07D487/04 ,  C07D487/08

公开(公告)号：EP3206686B1

公开(公告)日：2019-10-09

申请号：EP15833863.2

申请日：2015-08-20

申请人： Samumed, LLC

发明人： HOOD, John ,  KC, Sunil Kumar ,  KIBAR, Osman

IPC分类号： A61K31/44 ,  A61K31/404

公开(公告)号：EP3456325A3

公开(公告)日：2019-05-22

申请号：EP18182474.9

申请日：2014-02-21

申请人： Samumed, LLC

发明人： WALLACE, David Mark ,  HOOD, John ,  KUMAR KC, Sunil ,  BARROGA, Charlene

IPC分类号： A61K31/33 ,  C07D263/56 ,  C07D311/58 ,  C07D317/54 ,  C07D319/18 ,  C07D231/56 ,  C07D333/54 ,  C07D235/06 ,  C07D401/06 ,  C07D327/06 ,  C07D339/08 ,  C07D407/06 ,  C07D409/06 ,  C07D411/06 ,  C07D413/06 ,  C07D213/50 ,  C07D307/80 ,  C07D405/06 ,  A61P25/00

摘要： The present disclosure provides γ-diketones or analogs thereof, that activate Wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

公开(公告)号：EP3473099A1

公开(公告)日：2019-04-24

申请号：EP18191545.5

申请日：2012-09-13

申请人： Samumed, LLC

发明人： HOOD, John ,  KC, Sunil Kumar

IPC分类号： A01N43/56 ,  A61K31/415 ,  A61P35/00 ,  C07D401/14 ,  A61K45/06 ,  C07D405/14 ,  C07D401/10 ,  C07D413/12 ,  C07D401/04

摘要： Indazole-3-carboxamide compounds for treating various diseases and pathologies are disclosed. More particularly, the present invention concerns the use of an indazole-3-carboxamide compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.

公开(公告)号：EP2968249B1

公开(公告)日：2018-11-14

申请号：EP14753569.4

申请日：2014-02-21

申请人： Samumed, LLC

发明人： KUMAR KC, Sunil ,  WALLACE, David Mark ,  HOOD, John ,  BARROGA, Charlene

IPC分类号： A61K31/33 ,  C07D263/56 ,  C07D311/58 ,  C07D317/54 ,  C07D319/18 ,  C07D231/56 ,  C07D333/54 ,  C07D235/06 ,  C07D401/06 ,  C07D327/06 ,  C07D339/08 ,  C07D407/06 ,  C07D409/06 ,  C07D411/06 ,  C07D413/06 ,  C07D213/50 ,  C07D307/80 ,  C07D405/06

CPC分类号： C07D411/06 ,  C07D213/50 ,  C07D231/56 ,  C07D235/06 ,  C07D263/56 ,  C07D307/80 ,  C07D311/58 ,  C07D317/46 ,  C07D317/54 ,  C07D319/16 ,  C07D319/18 ,  C07D327/06 ,  C07D333/54 ,  C07D339/08 ,  C07D401/06 ,  C07D405/06 ,  C07D407/06 ,  C07D409/06 ,  C07D413/06

摘要： The present disclosure provides γ-diketones or analogs thereof, that activate Wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including Parkinson's disease, strokes, ischemic cerebral disease, epilepsy, Alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.

公开(公告)号：EP3371187A1

公开(公告)日：2018-09-12

申请号：EP16863178.6

申请日：2016-11-07

申请人： Samumed, LLC

发明人： HOOD, John ,  WALLACE, David Mark ,  KC, Sunil Kumar ,  YAZICI, Yusuf ,  SWEARINGEN, Christopher ,  DELLAMARY, Luis A.

IPC分类号： C07D471/04

CPC分类号： A61K31/496 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/5377 ,  A61P29/00

摘要： Indazole compounds for treating various diseases and pathologies are provided. More particularly, the use of an indazole compound or analogs thereof, in the treatment of inflammatory diseases or disorders is provided.

公开(公告)号：EP3206686A1

公开(公告)日：2017-08-23

申请号：EP15833863.2

申请日：2015-08-20

申请人： Samumed, LLC

发明人： HOOD, John ,  KC, Sunil Kumar ,  KIBAR, Osman

IPC分类号： A61K31/44 ,  A61K31/404

CPC分类号： A61K8/4986 ,  A61K8/35 ,  A61K8/41 ,  A61K8/49 ,  A61K8/4913 ,  A61K8/492 ,  A61K8/4926 ,  A61K8/494 ,  A61K8/4946 ,  A61K8/4953 ,  A61K8/4973 ,  A61K8/498 ,  A61K8/69 ,  A61K8/70 ,  A61K2800/10 ,  A61Q19/007 ,  A61Q19/02 ,  A61Q19/08

摘要： The present disclosure relates to compounds, cosmetic or dermopharmaceutical compositions comprising the same, and methods for using the compounds or compositions for treating, protecting, and/or improving the condition and/or aesthetic appearance of skin, for example, treating, preventing, ameliorating, reducing and/or eliminating fine lines and/or wrinkles of skin, or improving the appearance of fine lines and/or or wrinkles of skin comprising application of the compounds or compositions disclosed.

摘要翻译： 本公开涉及化合物，包含其的化妆品或皮肤用药物组合物，以及使用该化合物或组合物治疗，保护和/或改善皮肤状况和/或美学外观的方法，例如治疗，预防，改善 减少和/或消除皮肤的细纹和/或皱纹，或改善皮肤细纹和/或皱纹的外观，包括应用所公开的化合物或组合物。

公开(公告)号：EP3119393A1

公开(公告)日：2017-01-25

申请号：EP15765201.7

申请日：2015-03-20

申请人： Samumed, LLC

发明人： HOOD, John ,  KC, Sunil Kumar ,  WALLACE, David Mark ,  MITTAPALLI, Gopi Kumar ,  HOFILENA, Brian Joseph ,  MAK, Chi Ching ,  BOLLU, Venkataiah ,  EASTMAN, Brian

IPC分类号： A61K31/416

CPC分类号： C07D231/56 ,  C07B59/002 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D405/12 ,  C07D405/14 ,  C07D498/08

摘要： Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, fibrotic disorders, cartilage (chondral) defects, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, and neurological conditions/disorders/diseases linked to overexpression of DYRK1A.

摘要翻译： 公开了用于治疗各种疾病和病症的吲唑化合物。 更具体地，本公开涉及吲哚化合物或其类似物在治疗以Wnt途径信号传导（例如癌症，异常细胞增殖，血管发生，阿尔茨海默氏病，肺部疾病，纤维化病症， 软骨（软骨）缺陷和骨关节炎），由Wnt途径信号传导介导的细胞事件的调节以及与DYRK1A的过度表达有关的神经病症/病症/疾病。

公开(公告)号：EP2943198A2

公开(公告)日：2015-11-18

申请号：EP14737972.1

申请日：2014-01-08

申请人： Samumed, LLC

发明人： KUMAR KC, Sunil ,  HOOD, John

IPC分类号： A61K31/416 ,  A61K31/4184

CPC分类号： C07D401/14 ,  C07D405/14 ,  C07D409/14

摘要： Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.