公开(公告)号：EP0927253A1

公开(公告)日：1999-07-07

申请号：EP97953601.0

申请日：1997-12-30

申请人： Universidade Federal De Minas Gerais

发明人： PEREGRINO FERREIRA, Paulo, C. ,  GEESSIEN KROON, Erna ,  GUIMAR ES DA FONSECA, Flávio

IPC分类号： C07K14 ,  C12N15

CPC分类号： C07K14/005 ,  C12N2710/24022

摘要： The present invention describes recombinant growth factor (BEGF) protein isolated from the virus BeAn58058, its corresponding encoding recombinant DNA molecule and the process of production of the recombinant BEGF protein produced through genetic engineering techniques, to be used in human or veterinarian clinical or in research.

公开(公告)号：EP4190305A1

公开(公告)日：2023-06-07

申请号：EP21849693.3

申请日：2021-07-08

申请人： Universidade Federal De Minas Gerais - UFMG ,  Ondonto Tech Pesquisa e Inovação, Ltda

发明人： HEITMANN RODRIGUES, Ana Pacheli ,  ALVES DE OLIVEIRA, Luiz Carlos ,  BELCHIOR, Jadson Claudio ,  MORGAN DOS SANTOS ALVES, Luis Fernando ,  MAUAD DE ABREU, Fernando Antonio

IPC分类号： A61K6/00 ,  A61K6/17

摘要： The present technology relates to a product applied for teeth whitening based on the generation of active oxygen in the form of oxygen radical species in situ. The whitening gel comprises modified niobium compounds and its activity is maximized mainly if it is applied with hydrogen peroxide in low concentrations, from 1 to 10% (preferably 3% by mass), with stabilization by a thickener, preferably carbopol. The whitening gel can be used in teeth whitening without the need for additional light to the treatment, which allows its use in teeth whitening with greater efficiency than commercial products and with a significant potential to reduce side effects (hypersensitivity and inflammation). The developed product did not show cytotoxicity, and no significant inflammatory effect was observed in the pulp tissue. The present technology also describes a method for producing the whitening gel.

公开(公告)号：EP3362038A1

公开(公告)日：2018-08-22

申请号：EP16854666.1

申请日：2016-10-17

申请人： Natura Cosméticos S.A. ,  Universidade Federal De Minas Gerais - UFMG

发明人： DE MIRANDA CHAVES VASQUEZ PINTO, Luciana ,  DOMENES PALMIERI RODRIGUEZ, Débora ,  NICOLI, Jacques Robert ,  DOS SANTOS MARTINS, Flaviano ,  SOARES SILVA, Anna Karolina ,  DA SILVA, Simone Helena

IPC分类号： A61K8/99 ,  A61Q19/08 ,  A61Q19/00

CPC分类号： A61K8/99 ,  A61Q17/005 ,  A61Q19/08 ,  A61Q19/10

摘要： The present invention relates to a probiotic cosmetic formulation for the cosmetic treatment of the skin, comprising a microbiota and a cosmetically acceptable carrier. Preferably, betaines and/or prebiotic agents may be incorporated into said formulation. The invention also relates to the use of a microbiota in preparing said probiotic cosmetic formulation of the invention, and a method for the cosmetic treatment of the skin, which comprises administering to the skin of an individual the probiotic cosmetic formulation of the invention.

公开(公告)号：EP2899198B1

公开(公告)日：2018-05-02

申请号：EP13831141.0

申请日：2013-08-20

申请人： Universidade Federal De Minas Gerais - UFMG

发明人： DE LIMA PEREZ GARCIA, Maria Elena ,  NUNES DA SILVA, Carolina ,  DE MARCO ALMEIDA, Flávia ,  DA SILVA LOMEO, Rosangela ,  LACERDA BEIRÃO, Paulo Sérgio ,  SILVA TORRES, Fernanda ,  MONTEIRO DE CASTRO PIMENTA, Adriano

IPC分类号： C07K7/08 ,  A61K38/10 ,  A61P15/10 ,  A61K38/00 ,  C07K14/435

CPC分类号： C07K14/43518 ,  A61K38/00 ,  A61K38/10 ,  C07K7/08

摘要： The present invention relates to a synthetic peptide of 19 amino acids, called PnTx(19), constituted from the sequence of the native toxin PnTx2-6 of the Phoneutria nigriventer spider. It also relates to pharmaceutical compositions containing such a peptide and to the use thereof in the treatment of erectile dysfunction and/or in potentiating the erectile function.

公开(公告)号：EP3197033A1

公开(公告)日：2017-07-26

申请号：EP15842605.6

申请日：2015-09-17

申请人： Universidade Federal De Minas Gerais - UFMG

发明人： DE JESUS CARDOSO FILHO, Braz ,  MORAIS PARREIRAS, Thiago

IPC分类号： H02M1/12 ,  H02M7/68

CPC分类号： H02J3/01 ,  H02M1/12 ,  H02M1/4216 ,  H02M5/4585 ,  H02M7/68 ,  H02P23/26 ,  H02P27/08 ,  Y02B70/126

摘要： The present patent application relates to a method and equipment for eliminating harmonics based on two complementary techniques, namely the elimination of harmonics by selective harmonic elimination pulse-width modulation in conjunction with the multiple-wiring transformer. The association of these two resources is capable of reducing the harmonic distortion of currents to extremely low values, providing a truly unitary power factor. The technology is suitable for low and medium intensity alternating current - direct current and direct current - alternating current converters, which make interface with the electricity network and should have low harmonic distortion of the current because of the high power value involved, and also because of fragility of the electricity network (low power of short circuit at the coupling point).

摘要翻译： 本专利申请涉及基于两种互补技术消除谐波的方法和设备，即通过结合多重接线变压器通过选择性谐波消除脉冲宽度调制消除谐波。 这两种资源的关联能够将电流的谐波失真降低至极低值，从而提供真正的单一功率因数。 该技术适用于与电网接口的中低强度交流 - 直流和直流 - 交流转换器，由于涉及的功率值较高，因此应该具有较低的电流谐波失真，并且还因为 电网的脆弱性（耦合点短路功率低）。

公开(公告)号：EP2851081A1

公开(公告)日：2015-03-25

申请号：EP13787415.2

申请日：2013-05-13

申请人： Universidade Federal Do Pará ,  Universidade Federal de Minas Gerais-UFMG ,  Museu Paraense Emílio Goeldi ,  Instituto Evandro Chagas ,  Secretaria Executiva De Saúde Pública Do Estado Do

发明人： DOLABELA, Maria Fâni ,  MARTINS, Michel T. ,  BRANDÃO, Dayse Lúcia doNascimento ,  BORGES, Edinilza da Silva ,  PERCÁRIO, Sandro ,  MARINHO, Andrey Moacir do R. ,  SILVA, Thiago L. da ,  VILHENA, Thyago da Costa ,  VASCONCELOS, Flávio de ,  MOTA, Eduardo F. ,  SILVA, Adriana Veiga da Conceição ,  OLIVEIRA, Alaíde Braga de ,  BRANDÃO, Geraldo Célio ,  PAULA, Renata Cristina de ,  NASCIMENTO, Maria Fernanda Alves do ,  PÓVOA, Marinete Marins ,  COELHO-FERREIRA, Marlia Regina ,  BUSMAN, Dâmaris

IPC分类号： A61K36/88 ,  A61K31/122 ,  A61K125/00 ,  A61P33/06

CPC分类号： A61K36/88 ,  A61K31/122 ,  A61K2236/33 ,  A61K2236/37 ,  A61K2236/39 ,  Y02A50/411

摘要： The present invention describes the obtaining process of the dichloromethane fraction and subfractions from Eleutherine plicata, popularly known as "marupazinho, maruparí, palmeirinha, coquinho, marupaí, marupaú, marupá-piranga, and lírio-folha-de-palmeira". This invention comprises the obtaining process of pharmaceutical compositions that contain the dichloromethane fraction and/or naphthoquinone, as well as its use for malaria treatment. Extract and fractions were assayed and presented antiplasmodial activity, particularly against chloroquine-resistant Plasmodium falciparum (clone W2).

摘要翻译： 本发明描述的过程获得来自红葱属冠蚌，普遍称为 “marupazinho，maruparí，Palmeirinha，coquinho，marupaí，marupaú，Marupa-piranga，和利里奥-folha-DE-帕尔梅拉” 的二氯甲烷部分和亚组分。 本发明包括药物组合物的获得过程确实含有二氯甲烷部分和/或萘，以及其用于治疗疟疾的用途。 提取和分数进行测定并呈现抗疟原虫活性，特别是对耐氯喹的恶性疟原虫（克隆W2）。

公开(公告)号：EP2813154A1

公开(公告)日：2014-12-17

申请号：EP12859587.3

申请日：2012-12-21

申请人： Universidade Federal De Minas Gerais - UFMG

发明人： TEIXEIRA DA FONSECA, Sérgio ,  GUIMARÃES LOFFI, Renato

IPC分类号： A41D13/00 ,  A61F5/00

CPC分类号： A61F5/026 ,  A41D13/0015 ,  A61F5/01

摘要： The discussed matter is comprised of a biomechanical vest designed to optimize body posture and movement. Specifically, the equipment consists of a vest which has areas reinforced by a material that simulates the elastic tension usually provided by body structures. These areas of tensional reinforcement follow patterns of the musculoskeletal system architecture and aim to give appropriate support for posture and movements of children and adults with motor dysfunctions, as well as optimizing the performance of workers and sports practitioners during their activities.

摘要翻译： 一事一议由生物力学的背心设计，优化身体姿势和动作。 具体而言，具有由材料加强的区域做了背心的设备besteht模拟一般由身体结构提供的弹性张力。 张力增强这些地区遵循肌肉骨骼系统架构的模式，目标是给出姿态和孩子，跟运动功能障碍的成年人的运动适当的支持，以及在他们的活动优化工作者和体育从业者的表现。

公开(公告)号：EP2349257A1

公开(公告)日：2011-08-03

申请号：EP08772747.5

申请日：2008-06-17

申请人： Universidade Federal de Minas Gerais-UFMG

发明人： TEIXEIRA, Mauro Martins ,  DE SOUZA, Daniele da Glória

IPC分类号： A61K31/4196 ,  A61K31/4188 ,  A61P31/12

CPC分类号： A61K31/4188 ,  A61K31/4196 ,  Y02A50/385

摘要： The present invention refers to the use of PAF receptor antagonists in the treatment of infections caused by a virus of the Flaviviridae family, mainly Dengue and Hemorrhagic Dengue Fever as well as shock.

公开(公告)号：EP1420823A2

公开(公告)日：2004-05-26

申请号：EP02744957.8

申请日：2002-07-17

申请人： Universidade Federal de Minas Gerais-UFMG ,  Lopes Silva, Célio

发明人： LOPES SILVA, Célio ,  RODRIGUES, José, Maciel, Junior

IPC分类号： A61K39/39 ,  A61K9/50

CPC分类号： A61K9/1647 ,  A61K39/04 ,  A61K2039/55583 ,  A61K2039/55594

摘要： The present invention relates to compositions which are able to stimulate an immune response in a host inoculated with an antigen of interest or the gene vector that codifies it. This composition includes microspheres based on copolymers derived from lactic acid glycolic acid encapsulating antigens, gene vectors and/or adjuvants with immunostimulatory properties obtained from mycobacterial fractions. The materialization of the present invention is the use of trehalose dimycolate associated to a heat shock protein or to the plasmid containing the gene that codifies it, encapsulated in microspheres with size smaller than 10 νm, capable of inducing specific antobodies and cellular immune responses, as well as the secretion of cytokines implicated in the protection against infectious diseases and cancer, following administration of a single dose or several doses.

公开(公告)号：EP1044282A1

公开(公告)日：2000-10-18

申请号：EP97953602.6

申请日：1997-12-30

申请人： Universidade Federal De Minas Gerais

发明人： PEREGRINO FERREIRA, Paulo César ,  GEESSIEN KROON, Erna ,  BERNARDES MARGUTTI PINTO, Maria, Elizabeth ,  ALEIXO, Agdemir, Wáleria

IPC分类号： C12Q1/68

CPC分类号： C12Q1/68 ,  C12Q1/6806 ,  C12Q1/689

摘要： The present invention relates to a method for diagnosis, identification and characterization of M. tuberculosis or any other mycobacteria by using PCR and shift mobility assay (SMA). The method is based both on microheterogeneities observed within the 16S rRNA sequences established for mycobacteria and on nucleotide gaps and mismatches which cause a decrease in the electrophoretic mobility of DNA heteroduplex in polyacrylamide gels. The PCR strategy is based on the use of a specific primers for mycobacteria genera and divergence in sequences found in 16S rRNA coding gene. The difference in nucleotide sequence was enough to identify mycobacteria species, since a remarkable shift between single stranded and homoduplex bands in PAGE were observed among mycobacteria tested, when Mycobacterium tuberculosis was used as standard. The shift of PCR product of bacteria other than mycobacteria was observed above the single stranded band in PAGE, both in standard cultures and clinical specimens. SMA can thus provide a fast and sensitive method for detection and classification of mycobacteria in clinical samples as well as pure culture.