公开(公告)号：EP4186885A1

公开(公告)日：2023-05-31

申请号：EP21315257.2

申请日：2021-11-30

申请人： UNIVERSITE DE STRASBOURG ,  Centre National de la Recherche Scientifique

发明人： Dydio, Pawel ,  Sigrist, Michel

IPC分类号： C07C45/50 ,  C07C47/02

摘要： The invention relates to a process for the hydroformylation of propylene with carbon monoxide and hydrogen to selectively form iso-butanal with respect to n-butanal, the process implementing a hydroformylation catalyst in combination with a phosphine, the hydroformylation catalyst comprising a palladium catalyst which comprises the element PdX 2 , where X is a halogen element selected from iodine I and bromine Br, the phosphine is of the form the phosphine is of the form P(R)(R')(R"), where R, R' and R" each comprise an alkyl group or an aryl group or an alkoxy group or an amino group.

公开(公告)号：EP2389391A1

公开(公告)日：2011-11-30

申请号：EP10702081.0

申请日：2010-01-22

申请人： Centre National de la Recherche Scientifique CNRS ,  The Board Of Trustees Of The University Of Illinois ,  Universite De Strasbourg

发明人： METZGER, Daniel ,  CHAMBON, Pierre ,  ZHAO, Huimin ,  KATZENELLENBOGEN, John

IPC分类号： C07K14/72 ,  C12N9/00 ,  C12N15/90 ,  C12N9/90

CPC分类号： C07K14/721 ,  C07K2319/715 ,  C12N9/90

摘要： The present invention relates to a method for tightly temporally controlling the biological activity of a protein of interest in a vertebrate, upon induction of the activity of a fusion protein comprising said protein of interest and an ERM polypeptide containing a mutated ligand binding domain of the human oestrogen receptor α, with a synthetic ligand that does not interfere with oestrogen signalling. In particular, the present invention concerns a method for generating tightly temporally-controlled targeted somatic mutations in a vertebrate, preferably a mouse, by inducing the activity of a fusion protein comprising a site- specific recombinase protein and an ERM polypeptide, with a synthetic ligand devoid of oestrogenic and anti-oestrogenic activities.

公开(公告)号：EP2384329A1

公开(公告)日：2011-11-09

申请号：EP09806180.7

申请日：2009-12-28

申请人： Centre National de la Recherche Scientifique ,  Universite De Strasbourg

发明人： DE BARRY, Jean ,  LIEGEOIS, Corinne ,  HAEFELE, Alexandre ,  BURA, Thomas ,  ULRICH, Gilles ,  ZIESSEL, Raymond

IPC分类号： C07F5/02 ,  G01N33/68 ,  C07K14/47 ,  C07H23/00 ,  C07F9/6596

CPC分类号： C07F5/02 ,  C07D209/56

摘要： The invention relates to novel fluorescent compounds derived from non-fluorinated dipyrromethene-boron, to a method for preparing same and to the use thereof for the fluorescent marking of biological molecules. The invention also relates to biological molecules marked with said fluorescent compounds, and to the use thereof in detection methods such as medical diagnosis methods. More particularly, the detection methods of the invention are particularly useful for diagnosing neurodegenerative diseases such as Alzheimer's disease.

公开(公告)号：EP2341948A1

公开(公告)日：2011-07-13

申请号：EP09740173.1

申请日：2009-09-14

申请人： Centre National de la Recherche Scientifique ,  Universite De Strasbourg

发明人： PAHM-HUU, Cuong ,  KELLER, Nicolas ,  LEDOUX, Marc-Jacques ,  KELLER-SPITZER, Valérie ,  BEGIN, Dominique ,  GRANDCOLAS, Mathieu ,  JANOWSKA, Izabela ,  HAJESMAILI, Shabnam

IPC分类号： A61L9/20 ,  B01D53/85 ,  B01D53/86 ,  B01J19/12 ,  B01J21/18 ,  B01J27/20 ,  B01J35/00 ,  B01J35/04 ,  C02F1/32 ,  F24F3/16 ,  B01J27/224

CPC分类号： B01J19/08 ,  B01J21/063 ,  B01J23/30 ,  B01J23/42 ,  B01J27/224 ,  B01J35/004 ,  B01J35/04 ,  B01J35/06 ,  B01J37/0215 ,  B01J37/0217 ,  B01J37/0219 ,  B01J37/0244 ,  B01J37/084 ,  C02F1/32 ,  C02F1/725 ,  C02F2305/10

摘要： The invention relates to a photocatalyst that comprises a β-SiC cellular foam and a photocatalytically active phase directly deposited on said cellular foam or on an intermediate phase deposited on said cellular foam. The average size of the cells is 2500 μm to 5000 μm. The foam may comprise nanotubes or nanofibres (particularly of carbon, SiC, and TiO
2 ) that consist of, or carry as an intermediate phase, a photocatalytically active phase.

公开(公告)号：EP2225393A1

公开(公告)日：2010-09-08

申请号：EP08868164.8

申请日：2008-09-12

申请人： PolyPlus Transfection ,  Centre National de la Recherche Scientifique ,  Universite De Strasbourg

发明人： LENNE, Nathalie ,  ERBACHER, Patrick

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6832 ,  C12Q2525/113 ,  C12Q2563/113 ,  C12Q2525/119

摘要： The invention relates to a method for manipulating, isolating, detecting or amplifying a target nucleic acid in a sample by hybridization with an oligonucleotide-oligocation conjugate, comprising allowing said nucleic acid to react with an oligonucleotide- oligocation conjugate comprising at least A1 and Bj linked together directly or via a linker, wherein. A, is an i-mer oligonucleotides, with i = 3 to 50, where Ai is an oligomer with naturally or non naturally occurring nucleobases and/or pentafuranosyl groups and/or native phosphodiester bonds, optionally comprising a marker group. Bj is a j-mer organic oligocation moiety, with j = 1 to 50, where B is - HPO3-R1-(NH-R2)n-NH-R3-O-, where R1, R2 and R3 are lower alkylene, identical or different, NH-R2 moieties being identical or different when n is >1; HPO3-R1-CH(X)-R3-O-, where Ri and R3, identical or different, are lower alkylene and X is putrescine, spermidine or spermine residue.

公开(公告)号：EP2136799A1

公开(公告)日：2009-12-30

申请号：EP07811232.3

申请日：2007-08-10

申请人： Universite De Strasbourg ,  Centre National de la Recherche Scientifique

发明人： Winssinger, Nicolas ,  Barluenga, Sofia ,  Karplus, Martin

IPC分类号： A61K31/365 ,  C07D313/00 ,  C07D493/00

CPC分类号： C07D313/00 ,  C07D407/04 ,  C07D493/04

摘要： Disclosed are macrocyclic compounds of formulae I-V,which are analogs of the pochonin resorcylic acid lactones, and processes for the preparation of the compounds. The compounds disclosed are useful as inhibitors of kinases and Heat Shock Protein 90 (HSP 90). Also disclosed are pharmaceutical compositions comprising an effective kinase-inhibiting amount or an effective HSP90-inhibiting amount of the compounds and methods for the treatment of disorders that are mediated by kinases and HSP90.

公开(公告)号：EP3615673A1

公开(公告)日：2020-03-04

申请号：EP18725646.6

申请日：2018-04-23

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE STRASBOURG ,  Simon Fraser University ,  The U.S.A. as represented by the Secretary, Department of Health and Human Services

发明人： RYCKELYNCK, Michaël ,  AUTOUR, Alexis ,  UNRAU, Peter ,  DOLGOSHEINA, Elen ,  JENG, Sunny Chiu Yuk ,  PANCHAPAKESA, Shunker Shyam Sundhar ,  ABDOLAHZADEH, Amir ,  COJOCARU, Razvan ,  FERRÉ-D'AMARÉ, Adrian ,  TRACHMAN, Robert

IPC分类号： C12N15/115 ,  C12Q1/68

公开(公告)号：EP3611257A1

公开(公告)日：2020-02-19

申请号：EP19200815.9

申请日：2012-08-29

申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) ,  CNRS (Centre National de la Recherche Scientifique) ,  UNIVERSITE DE STRASBOURG ,  Association Française contre les Myopathies

发明人： Pourquie, Olivier ,  Chal, Jérôme

IPC分类号： C12N5/0775

摘要： The present invention relates to an ex vivo method for preparing induced paraxial mesoderm progenitor (iPAM) cells, said method comprising the step of culturing pluripotent cells in an appropriate culture medium comprising an effective amount of an activator of the Wnt signaling pathway and an effective amount of an inhibitor of the Bone Morphogenetic Protein (BMP) signaling pathway.

公开(公告)号：EP3266784A1

公开(公告)日：2018-01-10

申请号：EP16305672.4

申请日：2016-06-08

申请人： PIERRE FABRE MEDICAMENT ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE DE STRASBOURG ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： CAVARELLI, Jean ,  HALBY, Ludovic ,  ARIMONDO, Paola Barbara

IPC分类号： C07D473/34 ,  A61K31/52 ,  A61P35/00 ,  A61P9/00 ,  A61P11/00

CPC分类号： C07D473/34 ,  A61K45/06

摘要： The present invention relates to a compound of following formula (I):

or a pharmaceutically acceptable salt and/or solvate thereof,
notably for use thereof as a drug, notably in the treatment of cancer, or as a PRMT inhibitor.
The present invention relates also to a pharmaceutical composition containing such a compound and to a method for the preparation of such a compound.

摘要翻译： 本发明涉及下式（I）的化合物或其药学上可接受的盐和/或溶剂合物，特别是其用作药物，特别是用于治疗癌症或作为PRMT抑制剂。 本发明还涉及含有这种化合物的药物组合物以及制备该化合物的方法。

公开(公告)号：EP2516148B1

公开(公告)日：2014-06-18

申请号：EP10807630.8

申请日：2010-12-20

申请人： SOPREMA (SAS) ,  Universite De Strasbourg (Etablissement Public à Caractère Scientifique, Culturel et Professionel)

发明人： BINDSCHEDLER, Pierre, Etienne ,  PERRIN, Rémi ,  HABLOT, Elodie ,  ROBACH, Christine ,  AVEROUS, Luc ,  BOUQUEY, Michel

IPC分类号： B32B5/00 ,  D06N3/00 ,  E04D5/02

CPC分类号： E04D5/06 ,  B29K2075/00 ,  B29K2077/00 ,  B32B27/12 ,  B32B27/34 ,  B32B27/40 ,  B32B2262/04 ,  B32B2262/06 ,  B32B2262/062 ,  B32B2262/065 ,  B32B2307/7246 ,  B32B2307/7265 ,  B32B2307/73 ,  B32B2419/00 ,  B32B2419/06 ,  D06M15/564 ,  D06M15/693 ,  D06M2200/11 ,  D06M2200/12 ,  D06N5/00 ,  D06N2201/04 ,  D06N2201/042 ,  D06N2201/045 ,  D06N2209/125 ,  D06N2209/128 ,  D06N2209/142 ,  D06N2209/143