公开(公告)号：EP4327879A3

公开(公告)日：2024-05-22

申请号：EP23205273.8

申请日：2017-05-31

申请人： The Trustees of the University of Pennsylvania

发明人： RIDKY, Todd ,  NATALE, Christopher ,  WINKLER, Jeffrey

IPC分类号： A61K31/473 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K45/06 ,  C07D221/16 ,  C07D491/08 ,  C07D221/22 ,  C07D405/04 ,  C07D409/04 ,  C07D491/056 ,  A61K39/3955 ,  C07K16/2818 ,  A61K2039/50520130101 ,  C07K2317/7620130101 ,  A61P35/00 ,  A61P35/02 ,  A61K38/15 ,  A61K31/473 ,  A61K2300/0020130101

摘要： The present invention includes compounds, compositions and methods that are useful for preventing or treating melanoma or any other Myc-expressing cancer in a subject. In certain embodiments, the compounds comprise estrogen (including estrogen derivatives or analogues), a selective GPER agonist and/or another small molecule G-protein coupled receptor (GPCR) agonist that increases cancer cell differentiation.

公开(公告)号：EP4316512A3

公开(公告)日：2024-04-24

申请号：EP23203010.6

申请日：2016-10-27

申请人： The Trustees of The University of Pennsylvania

发明人： WILSON, James M. ,  Hinderer, Christian ,  ROTHWELL, William Thomas

IPC分类号： C07K16/10 ,  C07K16/18 ,  C12N15/861 ,  A61P25/28 ,  A61K39/395 ,  A61K9/00 ,  A61K39/00

CPC分类号： A61K39/395 ,  A61K39/3955 ,  C07K16/1063 ,  C07K16/18 ,  A61K2039/5420130101 ,  C07K2317/62220130101 ,  C07K2317/7120130101 ,  C12N2750/1414320130101 ,  C12N15/86 ,  A61P21/02 ,  A61P25/00 ,  A61P25/06 ,  A61P25/14 ,  A61P25/16 ,  A61P25/28 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/14 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22 ,  A61P39/02 ,  A61P9/00 ,  A61P9/10 ,  Y02A50/30

摘要： A composition comprising at least one AAV vector formulated for intrathecal delivery to the central nervous system is described. The composition comprises at least one expression cassette which contains sequences encoding an immunoglobulin construct linked to expression control sequences therefor and a pharmaceutically acceptable carrier. The immunoglobulin construct may be an immunoglobulin modified to have decreased or no measurable affinity for neonatal Fc receptor (FcRn).

公开(公告)号：EP4354139A1

公开(公告)日：2024-04-17

申请号：EP22382976.3

申请日：2022-10-13

申请人： Fundación Carlos Simón para la Investigación en Salud de la Mujer ,  The Trustees of the University of Pennsylvania

发明人： PLACHTA, Nicolas ,  SIMÓN, Carlos ,  BISSIERE, Stephanie

IPC分类号： G01N33/50 ,  G01N33/533 ,  G01N33/58 ,  C12Q1/6841

CPC分类号： C12Q1/6841 ,  G01N33/5091 ,  G01N33/582 ,  G01N2333/471220130101 ,  G01N33/689

摘要： The present invention relates to a method for obtaining one or more fluorescent images of one or more cells, the method comprising the steps of incubating the one or more cells with a first probe for fluorescence imaging of nuclear DNA and with a second probe for fluorescence imaging of actin and visualizing of the one or more cells stained with both probes by fluorescence microscopy. The method is particularly useful for monitoring embryo development and for diagnosing aneuploidy.

公开(公告)号：EP4282956A3

公开(公告)日：2024-03-13

申请号：EP23193601.4

申请日：2006-04-07

申请人： The Trustees of the University of Pennsylvania

发明人： VANDENBERGHE, Luk ,  GAO, Guangping ,  WILSON, James N.

IPC分类号： A61K48/00 ,  C12N15/864 ,  A61K35/76 ,  C12N7/00

摘要： A method of correcting singletons in a selected AAV sequence in order to increase the packaging yield, transduction efficiency, and/or gene transfer efficiency of the selected AAV is provided. This method involves altering one or more singletons in the parental AAV capsid to conform the singleton to the amino acid in the corresponding position(s) of the aligned functional AAV capsid.

公开(公告)号：EP4330391A1

公开(公告)日：2024-03-06

申请号：EP22796806.2

申请日：2022-04-29

申请人： The Trustees of the University of Pennsylvania

发明人： PARHIZ, Hamideh ,  WEISSMAN, Drew

IPC分类号： C12N15/11 ,  A61K9/51 ,  B82Y5/00

公开(公告)号：EP4329860A1

公开(公告)日：2024-03-06

申请号：EP22796812.0

申请日：2022-04-29

申请人： The Trustees of the University of Pennsylvania

发明人： BLUE, Rachel ,  SPADOLA, Michael

IPC分类号： A61M25/02 ,  A61B90/10 ,  A61B90/11 ,  A61M25/01 ,  A61M39/02

公开(公告)号：EP4305054A1

公开(公告)日：2024-01-17

申请号：EP22767860.4

申请日：2022-03-09

申请人： The Trustees of The University of Pennsylvania ,  The Regents of the University of California

发明人： SIURALA, Mikko ,  JUNE, Carl H. ,  POSEY, Avery ,  RIBAS, Antoni ,  KALBASI, Anusha

IPC分类号： C07K14/55 ,  C12N5/0783 ,  C07K14/705 ,  C12N15/861

公开(公告)号：EP4275699A2

公开(公告)日：2023-11-15

申请号：EP23193203.9

申请日：2013-02-22

申请人： The Trustees of the University of Pennsylvania

发明人： JUNE, Carl H. ,  SCHOLLER, John ,  POSEY, Avery D.

IPC分类号： A61K39/00

摘要： The present invention provides compositions and methods for treating cancer in a human. The invention includes relates to administering a genetically modified T cell expressing a CAR having an antigen binding domain, a transmembrane domain, a CD2 signaling domain, and a CD3 zeta signaling domain. The invention also includes incorporating CD2 into the CAR to alter the cytokine production of CAR-T cells in both negative and positive directions.

公开(公告)号：EP4256065A2

公开(公告)日：2023-10-11

申请号：EP21848319.6

申请日：2021-12-01

申请人： The Trustees of The University of Pennsylvania

发明人： WILSON, James, M. ,  SIMS, Joshua, Joyner ,  YUAN, Yuan

IPC分类号： C12N15/86 ,  C07K14/005

公开(公告)号：EP4256027A1

公开(公告)日：2023-10-11

申请号：EP21901670.6

申请日：2021-12-06

申请人： The Trustees of The University of Pennsylvania

发明人： HUH, Dongeun ,  PARK, Sunghee Estelle

IPC分类号： C12M1/04 ,  C12M3/00 ,  C12M1/34