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11.发明公开
公开(公告)号：EP4248957A1
公开(公告)日：2023-09-27
申请号：EP22828609.2
申请日：2022-05-13
发明人： CHUNG, Choon Hee , LEE, Eun Soo , HA, Kyung Bong , LEE, Dong Keon , PARK, Na Won , JO, Su Ho
IPC分类号： A61K31/12 , A61K31/444 , A61K45/06 , A61P1/16 , A23L33/10
摘要： The present invention relates to a pharmaceutical composition, quasi-drug, and food composition for preventing, ameliorating, or treating steatohepatitis, comprising a curcumin derivative and a TGF-β receptor inhibitor as active ingredients. In the composition, the TGF-β receptor inhibitor inhibits fibrosis of liver tissues, the curcumin derivative inhibits adipogenesis of hepatocyte increased during fibrosis inhibition process. Thus, compared to when a curcumin derivative or a TGF-β receptor inhibitor is administered alone as in the conventional cases, the composition exhibits an excellent effect of preventing and treating steatohepatitis, and therefore, can be used as a pharmaceutical composition, quasi-drug, and food composition for preventing, ameliorating, or treating metabolic liver diseases, including steatohepatitis.
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公开(公告)号：EP4234608A1
公开(公告)日：2023-08-30
申请号：EP22856135.3
申请日：2022-08-08
发明人： SON, Youngwook , BAHN, Hyong Min , KIM, Byeong-Su , KIM, Taehyung , YU, Yeji
摘要： The present disclosure provides a polycarbonate copolymer including a repeating unit represented by the following Chemical Formula 1, and can provide a polycarbonate copolymer having improved heat resistance by including a repeating unit having the following specific structure.
In Chemical Formula 1, R 1 , R 2 , n1 and n2 are as defined in the specification.-
13.发明公开
公开(公告)号：EP4170605A1
公开(公告)日：2023-04-26
申请号：EP21212014.1
申请日：2022-01-20
发明人： BYUN, Hye Ran , DO, Mi Rae , JEON, Seog Kyu , HONG, Ki Beom
摘要： A multi-level transferable region-based domain adaptive object detection apparatus (100) and method are provided. the apparatus includes: an image-level feature part (110) that extracts an image-level feature by providing unlabeled target data to a plurality of convolutional layers; an RPN-level feature part (130) that determines region candidates by providing the image-level feature to a region proposal network (RPN) and performing RPN-level domain adaptation and transferable region filtering; and an instance-level feature part (150) that extracts a region of interest (RoI) pooling feature by conducting dynamic instance sampling on the region candidates.
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公开(公告)号：EP4108766A1
公开(公告)日：2022-12-28
申请号：EP21757937.4
申请日：2021-02-15
发明人： KIM, Baek Gil , JANG, Yeonsue , CHO, Nam Hoon , KANG, Suki
摘要： The present invention relates to a method for producing a fibrosis-encapsulated tumoroid (FET), and the use of the fibrosis-encapsulated tumoroid. According to the present invention, an analogue that is close to real solid cancer tissue is produced using induced pluripotent stem cell-derived cell. The analogue has significant improvement over conventional tumoroids, which fail to perfectly reflect the characteristics of human solid cancer and have a very high probability of failure in the clinical validation stage. Thus, the present invention is expected to be widely used in the fields of new anticancer drug development and precision medicine.
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公开(公告)号：EP4083037A1
公开(公告)日：2022-11-02
申请号：EP20906363.5
申请日：2020-12-22
申请人： Yonsei University, University-Industry Foundation(UIF). , Daegu-Gyeongbuk Medical Innovation Foundation
发明人： KIM, Youngsoo , SHIN, Jisu , HONG, Ki Bum , YU, Ji Hoon , LEE, Ji Hoon , KIM, Da Rong , JEON, Hui-Jeon , SONG, Jaeyoung , PARK, Jin Wan , LEE, Ju Suk , LEE, Won Seok , KIM, Young-Kyu , KIM, Sung Hwan , YOON, Heeseok
IPC分类号： C07D417/06 , A61K31/427 , A61K31/437 , A61K31/4178 , C07D277/36 , C07D401/06 , C07D405/06 , C07D409/06 , C07D471/04 , A61P25/28
摘要： Provided are: a novel pyrrolidine derivative or a pharmaceutically acceptable salt thereof; and a pharmaceutical composition containing same and having the effects of inhibiting beta-amyloid and/or tau protein aggregation, and/or breaking down beta-amyloid and/or tau protein aggregates, and/or preventing and/or treating beta-amyloid and/or tau protein-associated diseases.
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公开(公告)号：EP3919888A3
公开(公告)日：2022-05-04
申请号：EP21175258.9
申请日：2021-05-21
发明人： KIM, Yong-Jun , KWON, Hong-Beom
IPC分类号： G01N15/02 , B03C3/017 , B03C3/02 , B03C3/47 , G01N15/06 , G01N27/02 , G01N27/66 , G01N27/70 , G01N1/22 , B01D57/02 , B03C3/38 , B03C3/12 , B03C3/41
摘要： A particle matter analysis device, an analysis method and a manufacturing method are disclosed. The particle matter analysis device includes a charger configured to receive power from a power supply device and to charge particles included in intaken air, an electrophoretic mobility particle collector configured to collect particles having electrophoretic mobility greater than a predetermined electrophoretic mobility among the charged particles based on an electrophoretic mobility and to measure a current of electrophoretic mobility particles, an aerodynamic particle collector configured to collect charged particles passing through the electrophoretic mobility particle collector based on an inertial force of the charged particles and to measure a current of aerodynamic particles, a filter configured to collect charged particles passing through the aerodynamic particle collector and to measure a current of filtered particles, and a processor, wherein the processor calculates a density of the particles based on a ratio of the current of electrophoretic mobility particles, the current of aerodynamic particles, and the current of filtered particles.
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17.发明公开
公开(公告)号：EP3967652A1
公开(公告)日：2022-03-16
申请号：EP20211720.6
申请日：2020-12-03
发明人： SHIM, Woo-young , KIM, Tae-young
IPC分类号： B82Y30/00 , B82Y40/00 , C01G28/00 , C30B29/40 , C30B29/68 , H01L21/02 , C30B23/00 , C30B29/10 , C30B29/60 , C30B29/64 , C30B33/06 , C30B33/10
摘要： Provided are a layered compound having indium and arsenic, a nanosheet that may be prepared using the same, and an electrical device including the materials. Provided is a layered compound represented by [Formula 1] Na 1-x In y As z (0≤x
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18.发明公开
公开(公告)号：EP3949963A1
公开(公告)日：2022-02-09
申请号：EP20782123.2
申请日：2020-04-01
发明人： CHOI, Jae Young , HAN, Gyoonhee , NAMKUNG, Wan , PARK, Sung Ha , PARK, Moo Suk
IPC分类号： A61K31/422 , A61K31/427 , A61P11/00
摘要： The present invention relates to a novel compound, and a composition for preventing or treating of respiratory disease comprising the novel compound, E- or Z-isomer thereof, optical isomer thereof, a mixture of two isomers thereof, precursor thereof, pharmaceutically acceptable salt thereof or solvate thereof as an active ingredient.
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公开(公告)号：EP3949913A1
公开(公告)日：2022-02-09
申请号：EP20778610.4
申请日：2020-03-25
发明人： SUNG, Jung Hoon , JUNG, Bo Young , YANG, Pil Sung
摘要： The present invention provides a drug-eluting stent. The present invention includes a main structure, and a drug delivery layer that is applied to the main structure and includes a fibrosis drug, wherein, when the main structure comes into contact with a target tissue, the fibrosis drug of the drug delivery layer is released into the target tissue to perform fibrous of the target tissue.
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公开(公告)号：EP3938788A1
公开(公告)日：2022-01-19
申请号：EP20755277.9
申请日：2020-02-12
申请人： Medpacto, Inc. , Yonsei University Medical College, Gangnam Severance Hospital, Department of Surgery , Sungkyunkwan University, Department of Biological Sciences
发明人： KIM, Seong Jin , YANG, Kyung-Min , JEONG, Joon , AHN, Sung Gwe , PARK, Seok Hee , KANG, Dong Woo
IPC分类号： G01N33/574 , G01N33/68 , G01N33/577 , C07K16/18
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