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公开(公告)号：EP0112669A3
公开(公告)日：1984-11-28
申请号：EP83307435
申请日：1983-12-07
IPC分类号： C07C93/14 , C07C93/24 , C07C91/23 , C07C121/75 , C07C103/76 , A61K31/135 , A61K31/22
CPC分类号： C07D265/14 , C07C215/42 , C07C215/64 , C07C215/70 , C07C235/34 , C07C255/36 , C07C255/37 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18
摘要： Novel phenethylamine derivatives are central nervous system antidepressants. The compounds are those having the formula
where A is
where the dotted line represents optional unsaturation;
R 1 and R 7 are, independently, hydrogen or C 1 -C 6 alkyl; R 2 is C 1 -C 6 alkyl; R 4 is hydrogen, C 1 -C 4 alkyl, formyl or C 2 -C 7 alkanoly; R 5 and R 6 are hydrogen or defined substituents and n is 0,1,2,3, or 4 and their pharmaceutically acceptable salts. Novel intermediates for the preparation of these compounds include those of the formulae摘要翻译： 新型苯乙胺衍生物是中枢神经系统抗抑郁药。 化合物是具有式
的那些化合物，其中虚线表示任选的不饱和键; R 1和R 7独立地是氢或C 1 -C 6烷基; R2是C1-C6烷基; R4是氢，C1-C4烷基，甲酰基或C2-C7链烷醇; P5和R6是氢或定义的取代基，n是0,1,2,3或4及其药学上可接受的盐。 用于制备这些化合物的新型中间体包括式CHEM> 1的那些 -
公开(公告)号：EP0395313B1
公开(公告)日：1999-12-15
申请号：EP90304251.3
申请日：1990-04-20
IPC分类号： C07D295/08 , C07D295/12 , C07D295/14 , A61K31/495 , C07D239/42
CPC分类号： C07D295/145 , C07C2601/14 , C07D239/42 , C07D295/088 , C07D295/13 , C07D295/15
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13.发明授权Aryl- and heteroaryl piperazinyl carboxamides having central nervous system activity 失效芳基和杂piperazinylcarboxamide与中枢神经系统的影响
公开(公告)号：EP0343961B1
公开(公告)日：1996-01-10
申请号：EP89305255.5
申请日：1989-05-24
IPC分类号： C07D295/12 , A61K31/495 , C07D239/42 , A61K31/505 , C07D407/12 , C07D209/42 , A61K31/40 , C07D307/84 , A61K31/34
CPC分类号： C07D239/42 , C07D209/42 , C07D295/13
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公开(公告)号：EP0539057A1
公开(公告)日：1993-04-28
申请号：EP92309160.7
申请日：1992-10-08
IPC分类号： C07F9/6506 , A61K31/675
CPC分类号： C07F9/65068
摘要： The compounds of the formula
wherein
R is hydrogen, lower alkyl, benzyl or pivaloyloxymethyl;
R¹ and R² are, independently, hydrogen, lower alkyl, lower alkoxy, trifluoromethyl, trifluoromethoxy, methanesulfonylamino, acetylamino, or halo, or when taken together R¹ and R² represent a methylenedioxy grouping;
and the pharmacologically acceptable salts thereof are NMDA antagonists useful in the treatment and prevention of central nervous system related pathological conditions resulting from overstimulation by excitatory amino acids.
Processes for preparing the compounds and pharmaceutical compositions containing them are also covered.摘要翻译： 式CHEM的化合物，其中R是氢，低级烷基，苄基或新戊酰氧基甲基; R 1和R 2独立地为氢，低级烷基，低级烷氧基，三氟甲基，三氟甲氧基，甲磺酰基氨基，乙酰氨基或卤素，或者当R 1和R 2表示亚甲二氧基时; 其药理学上可接受的盐是可用于治疗和预防由兴奋性氨基酸过度刺激引起的中枢神经系统相关病理状况的NMDA拮抗剂。 还包括制备含有它们的化合物和药物组合物的方法。
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公开(公告)号：EP0112669B1
公开(公告)日：1987-07-29
申请号：EP83307435.4
申请日：1983-12-07
IPC分类号： C07C93/14 , C07C93/24 , C07C91/23 , C07C121/75 , C07C103/76 , A61K31/135 , A61K31/22
CPC分类号： C07D265/14 , C07C215/42 , C07C215/64 , C07C215/70 , C07C235/34 , C07C255/36 , C07C255/37 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2601/18
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